N-methylated cyclic Enkephalin analogues retain high opioid receptor binding affinity

Chemical Biology and Drug Design

Volumn 75, Issue 2, 2010, Pages 182-188

  Weltrowska, Grazyna ^a   Berezowska, Irena ^a   Lemieux, Carole ^a   Chung, Nga N ^a   Wilkes, Brian C ^a   Schiller, Peter W ^a,b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

N methylation of peptides; Opioid activity profiles; Opioid peptide analogues; Opioid peptide SAR; Peptide synthesis; Theoretical conformational analysis of peptides

Indexed keywords

DELTA OPIATE RECEPTOR; ENKEPHALIN DERIVATIVE; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYL DEXTRO CYSTEINYL(NME)] AMIDE; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYL(NME) CYSTEINAMIDE]; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYL(NME) CYSTEINYL(NME)] AMIDE; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYL(NME) DEXTRO CYSTEINAMIDE]; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYL(NME) DEXTRO CYSTEINYL(NME)] AMIDE; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYLCYSTEINYL(NME)] AMIDE; H 2',6' DIMETHYLTYROSINE C[DEXTRO CYSTEINYLGLYCINYLPHENYLALANINYLCYSTEINYL]AMIDE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; GUINEA PIG; HYDROGEN BOND; ILEUM; LIPOPHILICITY; METHYLATION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; VAS DEFERENS;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; ENKEPHALINS; GUINEA PIGS; METHYLATION; MICE; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 74549116473     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00919.x     Document Type: Article

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