Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex

Metabolic Brain Disease

Volumn 24, Issue 4, 2009, Pages 723-731

  Casagrande Figueiredo, Vandré ^a   Feksa, Luciane Rosa ^a   Wannmacher, Clovis Milton Duval ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Adenylate kinase; Cysteamine; Cystine; Cystine dimethylester; Cystinosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; CREATINE KINASE; CYSTINE; CYSTINE DIMETHYLESTER; MERCAPTAMINE; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CYSTINOSIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC DISORDER; LYSOSOME; METABOLIC TRANSPORT DISORDER; NONHUMAN; PROTEIN CONTENT; RAT;

ADENYLATE CYCLASE; ANIMALS; BRAIN CHEMISTRY; BRAIN DISEASES, METABOLIC; CEREBRAL CORTEX; CREATINE KINASE; CYSTEAMINE; CYSTINE; CYSTINOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENERGY METABOLISM; HOMEOSTASIS; LYSOSOMES; RATS; RATS, WISTAR;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 74449090487     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-009-9141-x     Document Type: Article

References (38)

1. A Ben-Nun N Bashan R Potashnik R Cohen-Luria A Moran 1993 Cystine loading induces Fanconi's syndrome in rats: in vivo and vesicle studies Am. J. Physiol. 265 839 844
2. A Ben-Nun N Bashan R Potashnik R Cohen-luria A Moran 1992 Cystine dimethyl ester reduces the forces driving sodium-dependent transport in Llc-Pk1 cells Am. J. Physiol. 263 C516 C520 1:CAS:528:DyaK38XlvV2msLs%3D 1325121
3. A Burlacu V Jinga AV Gafencu M Simionescu 2001 Severity of oxidative stress generates different mechanisms of endothelial cell death Cell Tissue Res. 306 409 416 10.1007/s004410100424 1:CAS:528:DC%2BD3MXosFans7w%3D 11735041 (Pubitemid 33139899)
4. +-dependent transporters in cystine-loaded human renal cells: electrophysiological studies on the Fanconi syndrome of cystinosis J. Am. Soc. Nephrol. 13 2085 2093 10.1097/01.ASN.0000023681.13865.25 (Pubitemid 34790785)
5. + -ATPase in the inhibition of proximal tubule transport with intracellular cystine loading J. Clin. Invest. 87 955 961 10.1172/JCI115103 1:CAS:528:DyaK3MXhvVegsLg%3D 1847941
6. Das, U.N. (2006). Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule. Med. Sci. Monit. 12: RA79-84
7. PP Dzeja A Terzic 2003 Phosphotransfer networks and cellular energetics J. Exp. Biol. 206 2039 2047 10.1242/jeb.00426 1:CAS:528:DC%2BD3sXlslaltb8%3D 12756286 (Pubitemid 36761807)
8. PP Dzeja R Bortolon C Perez-Terzic EL Holmuhamedov A Terzic 2002 Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer Proc. Natl. Acad. Sci. USA 99 10156 10161 10.1073/pnas.152259999 1:CAS:528:DC%2BD38XlslKgtbs%3D 12119406 (Pubitemid 34831188)
9. PP Dzeja KT Vitkevicius MM Redfield JC Burnettm A Terzic 1999 Adenylate Kinase-Catalyzed Phosphotransfer in the Myocardium: Increased Contribution in Heart Failure Circ. Res. 84 1137 1143 1:CAS:528:DyaK1MXjsVygsrs%3D 10347088
10. LR Feksa A Cornelio CS Dutra-Filho ATS Wyse M Wajner CMD Wannmacher 2004 Inhibition of pyruvate kinase activity by cystine in brain cortex of rats Brain. Res. 1012 93 100 10.1016/j.brainres.2004.03.035 1:CAS:528:DC%2BD2cXktF2ltbw%3D 15158165 (Pubitemid 38648903)
11. RMM Fleck V Rodrigues-Junior J Giacomazzi D Parissoto CS Dutra-Filho ATS Wyse M Wajner CMD Wannmacher 2005 Cysteamine prevents and reverses the inhibition of creatine kinase activity caused by cystine in rat brain cortex Neurochem. Int. 46 391 397 10.1016/j.neuint.2004.11.008 1:CAS:528: DC%2BD2MXhvVeksb8%3D 15737437 (Pubitemid 40292719)
12. JW Foreman LL Benson M Wellons ED Avner W Sweeney I Nissim I Nissim 1995 Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis J. Am. Soc. Nephrol. 6 269 272 1:CAS:528:DyaK2MXosF2itL0%3D 7579095
13. JW Foreman MA Bowring J Lee B States S Segal 1987 Effect of cystine dimethyl ester on renal solute handling and isolated renal tubule transport in the rat: A new model Fanconi syndrome Metab. 36 1185 1191 10.1016/0026-0495(87) 90246-0 1:CAS:528:DyaL1cXitVSkuw%3D%3D
14. WA Gahl 2003 Early oral cysteamine therapy for nephropathic cystinosis Eur. J. Pediatr. 162 1 38 41 10.1007/s00431-003-1349-x
15. WA Gahl JG Thoene JA Schneider 2002 Cystinosis N. Engl. J. Med. 347 111 121 10.1056/NEJMra020552 12110740 (Pubitemid 34753482)
16. Gahl WA, Thoene JG, Schneider JA (2001) Cystinosis: a disorder of lysosomal membrane transport. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic & Molecular Bases of Inherited Diseases. McGraw- Hill, New York, pp 5085-5108
17. FB Gonzalez S Llesuy A Boveris 1991 Hydroperoxide initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle Free Radic. Biol. Med. 10 93 100 10.1016/0891-5849(91)90002-K
18. A Kessler M Biasibetti DA da Silva Melo M Wajner CS Dutra-Filho ATS Wyse CMD Wannmacher 2008 Antioxidant Effect of Cysteamine in Brain Cortex of Young Rats Neurochem. Res. 33 737 744 10.1007/s11064-007-9486-7 1:CAS:528: DC%2BD1cXjsFGitL8%3D 17940891
19. GF Laube V Shah VC Stewart IP Hargreaves MR Haq SJ Heales WG van't Hoff 2006 Glutathione depletion and increased apoptosis rate in human cystinotic proximal tubular cells Pediatr. Nephrol. 21 503 509 10.1007/s00467-006-0005-x 16508773
20. Leech NL, Barrett KC, Morgan GA (2005) SPSS for intermediate statistics. Use and interpretation, Lawrence Erlbaum Associates Publishers, London, pp 46-62
21. EN Levtchenko MJG Wilmer AJM Janssen JB Koenderink AJ Visch PH Willems A Graaf-Hess HJ Blom LP van den Heuvel LA Monnens 2006 Decreased ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts Pediatr. Res. 59 287 292 10.1203/01.pdr.0000196334.46940.54 1:CAS:528: DC%2BD28XmslagsQ%3D%3D 16439594 (Pubitemid 43841004)
22. SF Llesuy J Milei H Molina 1985 Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 40-epiadriamycin in mice Tumori. 71 3 241 249 1:CAS:528:DyaL2MXkvFynsLw%3D 3861023
23. JB Lloyd 1986 Disulphide reduction in lysosomes. The role of cysteine Biochem. J. 237 1 271 272 1:CAS:528:DyaL28XktlOlsLs%3D 3800880
24. OH Lowry NJ Rosebrough AL Farr 1951 Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
25. PRP Oliveira V Rodrigues-Junior VC Rech CMD Wannmacher 2007 Cystine Inhibits Creatine Kinase Activity in Pig Retina Arch. Med. Res. 38 164 169 10.1016/j.arcmed.2006.09.013 (Pubitemid 46080546)
26. IT Oliver 1955 A Spectrophotometric Method for the Determination of Creatine Phosphokinase and Myokinase Biochem. J. 61 1 116 122 1:CAS:528:DyaG2MXosVOmtA%3D%3D 13260184
27. MA Park JG Thoene 2005 Potential role of apoptosis in development of the cystinotic phenotype Pediatr. Nephrol. 20 441 446 10.1007/s00467-004-1712-9 15622500 (Pubitemid 40392614)
28. RL Pisoni GY Park VQ Velilla JG Thoene 1995 Detection and characterization of a transport system mediating cysteamine entry into human fibroblast lysosomes. Specificity for aminoethylthiol and aminoethylsulfide derivatives J. Biol. Chem. 270 1179 1184 10.1074/jbc.270.3.1179 1:CAS:528:DyaK2MXjtFOktrg%3D 7836377
29. NC Price M Cohn RH Schirmer 1975 Fluorescent and Spin Label Probes of the Environments of the Sulfhydryl Groups of Porcine Muscle Adenylate Kinase J. Biol. Chem. 250 644 652 1:CAS:528:DyaE2MXht1Srur0%3D 163231
30. D Pucar E Janssen PP Dzeja N Juranic S Macura B Wieringa A Terzic 2000 Compromised Energetics in the Adenylate Kinase AK1 Gene Knockout Heart under Metabolic Stress J. Biol. Chem. 275 41424 41429 10.1074/jbc.M007903200 1:CAS:528:DC%2BD3MXjsVKhtQ%3D%3D 11006295 (Pubitemid 32054978)
31. VC Rech LR Feksa MFA Amaral GW Koch M Wajner CS Dutra-Filho ATS Wyse CMD Wannmacher 2007 Promotion of oxidative stress in kidney of rats loaded with cystine dimethyl ester Pediatr. Nephro. L 22 1121 1128 10.1007/s00467-007-0494-2
32. TG Rosa ATS Wyse M Wajner CMD Wannmacher 2004 Cysteamine prevents and reverses the inhibition of pyruvate kinase activity caused by cystine in rat heart Biochim. Biophys. Acta 1689 114 119 1:CAS:528:DC%2BD2cXkvVKrtLk%3D 15196592
33. RF Salmon M Baum 1990 Intracellular Cystine Loading Inhibits Transport in the Rabbit Proximal Convoluted Tubule J. Clin. Invest. 85 340 344 10.1172/JCI114443 1:CAS:528:DyaK3cXhtlKrtb0%3D 2298908
34. M Town G Jean S Cherqui M Attard L Forestier S Whitmore D Callen O Gribouval M Broyer G Bates W van't Hoff C Antignac 1998 A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis Nat. Genet. 18 319 324 10.1038/ng0498-319 1:CAS:528:DyaK1cXit1egsr8%3D 9537412 (Pubitemid 28158158)
35. AG Weeds L Noda 1968 Amino Acid Sequences around the Thiol Groups of Myokinase Biochem J. 107 311 312 1:CAS:528:DyaF1cXhtVait70%3D 5641885
36. M Willemoes M Kilstrup 2005 Nucleoside triphosphate synthesis catalysed by Adenylate Kinase is ADP dependent Arch. Biochem. Biophys. 444 195 199 10.1016/j.abb.2005.10.003 1:CAS:528:DC%2BD2MXht1OltL7J 16297370 (Pubitemid 41728351)
37. MJ Wilmer PH Willems S Verkaart HJ Visch A de Graaf-Hess HJ Blom LA Monnens LP van den Heuvel EN Levtchenko 2007 Cystine dimethylester model of cystinosis: still reliable? Pediatr. Res. 62 151 5 10.1203/PDR.0b013e31809fd9a7 1:CAS:528:DC%2BD2sXnslKqtro%3D 17597653 (Pubitemid 47205712)
38. MJ Wilmer A de Graaf-Hess HJ Blom HB Dijkman LA Monnens LP van den Heuvel EM Levtchenko 2005 Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells Biochem. Biophys. Res. Commun. 337 610 614 10.1016/j.bbrc.2005.09.094 1:CAS:528:DC%2BD2MXhtFWhsbnE 16202976 (Pubitemid 41429328)