Is Presence of ANCA in Crescentic IgA Nephropathy a Coincidence or Novel Clinical Entity? A Case Series

American Journal of Kidney Diseases

Volumn 55, Issue 2, 2010, Pages 259-268

  Bantis, Christos ^a,b   Stangou, Maria ^b   Schlaugat, Christoph ^c   Alexopoulos, Efstathios ^b   Pantzaki, Aphroditi ^b   Memmos, Dimitrios ^b   Ivens, Katrin ^a   Heering, Peter J ^a,c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

antineutrophil cytoplasmic autoantibodies (ANCAs); crescents; IgA nephropathy; rapidly progressive glomerulonephritis

Indexed keywords

ANTIHYPERTENSIVE AGENT; AZATHIOPRINE; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; CORTICOSTEROID; CREATININE; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRIN; FISH OIL; HEMOGLOBIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEINASE;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY SCREENING; ANTIHYPERTENSIVE THERAPY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION; HEMATURIA; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY FUNCTION; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; RETROSPECTIVE STUDY; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; FEMALE; GLOMERULONEPHRITIS, IGA; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 74449086794     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.09.031     Document Type: Article

References (22)

1. Harper S.J., Pringle J.H., Wicks A.C., et al. Expression of J chain mRNA in duodenal IgA plasma cells in IgA nephropathy. Kidney Int 45 3 (1994) 836-844
2. Harper S.J., Allen A.C., Pringle J.H., and Feehally J. Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA. J Clin Pathol 49 1 (1996) 38-42
3. Mestecky J., Tomana M., Crowley-Nowick P.A., Moldoveanu Z., Julian B.A., and Jackson S. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 104 (1993) 172-182
4. Haas M. Histologic subclassification of IgA nephropathy: a clinicopathologic study of 244 cases. Am J Kidney Dis 29 6 (1997) 829-842
5. Tumlin J.A., and Hennigar R.A. Clinical presentation, natural history, and treatment of crescentic proliferative IgA nephropathy. Semin Nephrol 24 3 (2004) 256-268
6. O'Donoghue D.J., Nusbaum P., Noel L.H., Halbwachs-Mecarelli L., and Lesavre P. Antineutrophil cytoplasmic antibodies in IgA nephropathy and Henoch-Schönlein purpura. Nephrol Dial Transplant 7 6 (1992) 534-538
7. Allmaras E., Nowack R., Andrassy K., Waldherr R., van der Woude F., and Ritz E. Rapidly progressive IgA nephropathy with anti-myeloperoxidase antibodies benefits from immunosuppression. Clin Nephrol 48 5 (1997) 269-273
8. Martin S.J., Audrain M.A., Baranger T., et al. Recurrence of immunoglobulin A nephropathy with immunoglobulin A antineutrophil cytoplasmic antibodies following renal transplantation. Am J Kidney Dis 29 1 (1997) 125-131
9. McGregor D., Lynn K.L., and Robson R. Rapidly progressive IgA nephropathy with anti-myeloperoxidase antibodies responding to immunosuppression. Clin Nephrol 50 1 (1998) 64
10. Ramirez S.B., Rosen S., Niles J., and Somers M.J. IgG antineutrophil cytoplasmic antibodies in IgA nephropathy: a clinical variant?. Am J Kidney Dis 31 2 (1998) 341-344
11. Haas M., Jafri J., Bartosh S.M., Karp S.L., Adler S.G., and Meehan S.M. ANCA-associated crescentic glomerulonephritis with mesangial IgA deposits. Am J Kidney Dis 36 4 (2000) 709-718
12. Tagboto S., Carr S., Varghese A., Allen A., Feehally J., and Furness P. IgA nephropathy, antineutrophil cytoplasmic antibodies and crescentic glomerulonephritis in a patient with the Hermansky-Pudlak syndrome. Am J Nephrol 21 1 (2001) 58-62
13. Lui S.L., Chan K.W., Yip P.S., Chan T.M., Lai K.N., and Lo W.K. Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient. Am J Kidney Dis 40 4 (2002) E14
14. Jimbo R., Ubara Y., Tagami T., et al. A pediatric occurrence of crescentic glomerulonephritis associated with antineutrophil cytoplasmic antibodies and mesangial IgA deposits. Clin Nephrol 68 2 (2007) 104-108
15. Ogawa N., Yano S., Yamane Y., et al. MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy. Clin Exp Nephrol 11 4 (2007) 326-331
16. Hagen E.C., Daha M.R., Hermans J., et al. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization. Kidney Int 53 3 (1998) 743-753
17. Xiao H., Heeringa P., Hu P., et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 110 7 (2002) 955-963
18. Han W.K., Choi H.K., Roth R.M., McCluskey R.T., and Niles J.L. Serial ANCA titers: useful tool for prevention of relapses in ANCA-associated vasculitis. Kidney Int 63 3 (2003) 1079-1085
19. Waldherr R., Rambausek M., Duncker W.D., and Ritz E. Frequency of mesangial IgA deposits in a non-selected autopsy series. Nephrol Dial Transplant 4 11 (1989) 943-946
20. Lai F.M., Li E.K., Suen M.W., Lui S.F., Li P.K., and Lai K.N. Pulmonary hemorrhage. A fatal manifestation in IgA nephropathy. Arch Pathol Lab Med 118 5 (1994) 542-546
21. Medcalf J.F., Brownjohn A.M., and Turney J.H. Pulmonary haemorrhage in association with IgA nephropathy. Nephrol Dial Transplant 11 6 (1996) 1148-1149
22. Levy J.B., Hammad T., Coulthart A., Dougan T., and Pusey C.D. Clinical features and outcome of patients with both ANCA and anti-GBM antibodies. Kidney Int 66 4 (2004) 1535-1540