A procedure for the assessment of the toxicity of intermediates and products formed during the accidental thermal decomposition of a chemical species

Journal of Hazardous Materials

Volumn 176, Issue 1-3, 2010, Pages 575-578

  Di Somma, Ilaria ^a   Pollio, Antonino ^a   Pinto, Gabriele ^a   De Falco, Maria ^a   Pizzo, Elio ^a   Andreozzi, Roberto ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Accident; Calorimetry; Thermal decomposition; Toxicology

Indexed keywords

A-THERMAL; CHEMICAL SPECIES; DECOMPOSITION PROCESS; EUROPEAN LEGISLATION; HUMAN CELLS; LOSS OF CONTROL; ONSET TEMPERATURE; PARENT COMPOUNDS; TEMPERATURE RANGE; THERMAL BEHAVIOURS; THERMAL DECOMPOSITION; THERMAL DECOMPOSITION PRODUCTS; THERMAL DECOMPOSITIONS; TOXICOLOGICAL ASSESSMENT;

ACCIDENTS; CALORIMETRY; CHEMICAL COMPOUNDS; GRAFTING (CHEMICAL); MIXTURES; MOLECULES; PHOTORESISTS; SYNTHESIS (CHEMICAL); THERMOGRAVIMETRIC ANALYSIS; TOXICITY;

PYROLYSIS;

CUMENE HYDROPEROXIDE; INDUSTRIAL CHEMICAL; PARATHION;

ACCIDENT; ASSESSMENT METHOD; CALORIMETRY; CELL ORGANELLE; THERMAL DECOMPOSITION; TOXICOLOGY;

ALGA; ARTICLE; BIOASSAY; CALORIMETRY; CHEMICAL REACTION; CONTROLLED STUDY; DECOMPOSITION; ECOTOXICITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; TEMPERATURE; TOXICITY TESTING; UMBILICAL VEIN;

ALGAE; CALORIMETRY; CELL LINE; CHEMICAL HAZARD RELEASE; CHEMICAL INDUSTRY; HOT TEMPERATURE; HUMANS; METHODS; TOXICITY TESTS;

ALGAE;

EID: 74449086244     PISSN: 03043894     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2009.11.067     Document Type: Article

References (12)

1. Directive 96/82/EC of the European Parliament and of the Council of 9 December 1996, Official Journal OJ L 10 of 14.01.1997.
2. http://ec.europa.eu/environment/seveso/index.htm
3. Cordella M., Tugnoli A., Barontini F., Spadoni G., and Cozzani V. Inherent safety of substances: identification of accidental scenarios due to decomposition products. J. Loss Prevent. Process Ind. 22 (2009) 455-462
4. Andreozzi R., Di Somma I., Pollio A., Pinto G., and Sanchirico R. Toxicity of unwanted intermediates and products formed during accidental thermal decomposition of chemicals. J. Hazard. Mater. 150 (2008) 433-437
5. Regulation (EC) No. 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency.
6. Priestley I., and Luginbuehl M. A comparison of DSC and Radex for the investigation of safety parameters for inhomogeneous systems. Proc. Hazards XIX Process Safety and Environmental Protection. Manchester, England, 27-30 March (2006) 570
7. Watanabe M.M. Freshwater culture media. In: Andersen R.A. (Ed). Algal Culturing Techniques (2005), Elsevier Academic Press, London 13-20
8. Gulley D. Toxstat Version 3.5 (1996), Western Ecosystems Technology, Inc.
9. US EPA, A Linear Interpolation Method for Sublethal Toxicity: The Inhibition Concentration (ICp) Approach. National Effluent Toxicity Assessment Center Technical Report 03-93. Environmental Research Laboratory, Duluth, 1993.
10. Abe K., and Kimura H. Amyloid beta toxicity consists of a Ca(2+)-independent early phase and a Ca(2+)-dependent late phase. J. Neurochem. 67 (1996) 2074-2078
11. Daston G.P., and McNamee P. Alternatives to toxicity testing in animals: challenges and opportunities. Environ. Health Perspect. 113 (2005) 6-15
12. Pablos M.V., Fernàndez C., Del Mar Babin M., Navas J.M., Carbonell G., Martini F., Garcia-Hortiguela P., and Tarazona J.V. Use of a novel battery of bioassays for the biological characterisation of hazardous wastes. Ecotoxicol. Environ. Saf. 72 (2009) 1594-1600