Wound fluid inhibits wound fibroblast nitric oxide synthesis

Journal of Surgical Research

Volumn 122, Issue 1, 2004, Pages 43-48

  Schäffer, Michael R ^a,c   Tantry, Udaya ^b   Barbul, Adrian ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b SINAI HOSPITAL OF BALTIMORE   (United States)

^c ST JOSEF HOSPITAL   (Germany)

Author keywords

fibroblast; nitric oxide; rat; wound fluid; wound healing

Indexed keywords

AMMONIUM SULFATE; ARGININE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRITE; POLYVINYL ALCOHOL SPONGE; REAGENT; SEPHADEX; SIALIDASE; TRYPSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GEL FILTRATION; HEAT TOLERANCE; IMPLANTATION; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC POINT; LIQUID; MALE; MOLECULAR WEIGHT; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SKIN FIBROBLAST; SUPERNATANT; SYNTHESIS; WOUND HEALING IMPAIRMENT;

ANIMALS; BODY FLUIDS; CELLS, CULTURED; DRUG COMBINATIONS; FIBROBLASTS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MALE; MICE; MOLECULAR WEIGHT; NITRIC OXIDE; PROTEINS; RATS; RATS, INBRED LEW; SKIN; TIME FACTORS; WOUNDS, PENETRATING;

EID: 7444255420     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2004.05.009     Document Type: Article

References (30)

1. B. Stallmeyer, H. Kampfer, N. Kolb, J. Pfeilschifter, S. Frank The function of nitric oxide in wound repair inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization J. Invest. Dermatol. 113 1999 1090
2. M. Schäffer, U. Tantry, F.J. Thornton, A. Barbul Inhibition of nitric oxide synthesis in wounds pharmacology and effect on accumulation of collagen in wounds in mice Eur. J. Surg. 165 1999 262
3. M. Schäffer, P.A. Efron, F.J. Thornton, K. Klingel, S.S. Gross, A. Barbul Nitric oxide, an autokrine regulator of wound fibroblast synthetic function J. Immunol. 158 1997 2375
4. L. Germain, A. Jean, F.A. Auger, D.R. Garrel Human wound healing fibroblasts have greater contractile properties than dermal fibroblasts J. Surg. Res. 57 1994 268
5. M.C. Regan, S.J. Kirk, H.L. Wasserkrug, A. Barbul The wound environment as a regulator of fibroblast phenotype J. Surg. Res. 50 1991 442
6. M. Schäffer, U. Tantry, G. Ahrendt, H.L. Wasserkrug, A. Barbul Stimulation of fibroblast proliferation and matrix contraction by wound fluid Int. J. Biochem. Cell Biol. 29 1997 231
7. D.A. Geller, A.K. Nussler, M. Di Silvio, C.J. Lowenstein, R.A. Shapiro, S.C. Wang, R.L. Simmons, T.R. Billiar Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes Proc. Natl. Acad. Sci. USA 90: 1993 522
8. M.B. Witte, Barbul A. Role of nitric oxide in wound repair. Am. J. Surg. 183 2002 406
9. R.I. Freshney Disaggregation of the tissue and primary culture R.I. Freshney Culture of Animal Cells. A Manual of Basic Technique 1987 Wiley-Liss New York 113
10. J.W. Madden, E.E. Peacock Studies on the biology of collagen during wound healing. I. Rate of collagen synthesis and deposition in cutaneous wounds of the rat Surgery 64 1968 288
11. R.B. Lorsbach, W.J. Murphy, C.L. Lowenstein, S.H. Snyder, S.W. Russel Expression of nitric oxide synthase gene in mouse macrophages activated for tumor cell killing J. Biol. Chem. 268 1993 1908
12. 15N]nitrate in biological fluids Anal. Biochem. 126 1982 131
13. C. Labarca, K. Paigen A simple, rapid and selective DNA assay procedure Anal. Biochem. 102 1980 344
14. N. Lavnikova, D.L. Laskin Unique patterns of regulation of nitric oxide production in fibroblasts J. Leukoc. Biol. 58 1995 451
15. M. Schäffer, A. Barbul Lymphocyte function in wound healing and following injury Br. J. Surg. 85 1998 444
16. M. Schäffer, U. Tantry, R.A. van Wesep, A. Barbul Nitric oxide metabolism in wounds J. Surg. Res. 71: 1997 25
17. R.H. Lee, D. Efron, U. Tantry, A. Barbul Nitric oxide in the healing wound a time course study J. Surg. Res. 101 2001 104
18. D.T. Efron, A. Barbul Subcutaneous sponge models Methods Mol. Med. 78 2003 83
19. J.E. Albina, C.D. Mills, A. Barbul, C.E. Thirkill, W. Henry, B. Mastrofrancesco, M.D. Caldwell Arginine metabolism in wounds Am. J. Physiol. 254 1987 E459
20. C.A. Cobbold The role of nitric oxide in the formation of keloid and hypertrophic lesions Med. Hypothesis 57 2001 497
21. T.J. Guzik, R. Korbut, T. Adamek-Guzik Nitric oxide and superoxide in inflammation and immune regulation J. Physiol. Pharmacol. 54 2003 469
22. H.D. Kim, H.S. Kang, G. Rimbach, Y. Park Heat shock and 5-azacytidine inhibit nitric oxide synthesis and TNF-alpha secretion in activated macrophages Antioxid. Redox Signal. 1 1999 297
23. B.S. Taylor, L.H. Alarcon, T.R. Billiar Inducible nitric oxide synthase in the liver regulation and function Biochemistry 63 1998 766
24. J. Leiper, P. Vallance Biological significance of endogenous methylarginines that inhibit nitric oxide synthases Cardiovasc. Res. 43 1999 542
25. V. Salmon-Ehr, L. Ramont, G. Godeau, P. Birembaut, M. Guenounou, P. Bernard, F.X. Marquart Implication of IL-4 in wound healing Lab. Invest. 80 2000 1337
26. Y. Sato, T. Ohshima, T. Kondo Regulatory role of endogenous IL-10 in cutaneous inflammatory response of murine wound healing Biochem. Biophys. Res. Commun. 265 1999 194
27. J.N. Keagle, W.J. Welch, D.M. Young Expression of heat shock proteins in a linear rodent wound Wound Repair Regen. 9 2001 378
28. M. Yoshida, Y. Xia Heat shock protein 90 as an endogenous protein enhancer of nitric oxide synthase J. Biol. Chem. 278 2003 36953
29. A.B. Roberts The ever-increasing complexity of TGF-beta signaling. Cytokine Growth Factor Rev. 13 2002 3
30. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248