Concurrent use of 5% natamycin and 2% econazole for the management of fungal keratitis

Cornea

Volumn 23, Issue 8, 2004, Pages 793-796

  Prajna, N Venkatesh ^a,b   Nirmalan, Praveen K ^a   Mahalakshmi, Rajendran ^a   Lalitha, Prajna ^a   Srinivasan, Muthiah ^a  

^a ARAVIND MEDICAL RESEARCH FOUNDATION   (India)

^b ARAVIND EYE CARE SYSTEM   (India)

Author keywords

Econazole; Fungal keratitis; Medication; Natamycin

Indexed keywords

ECONAZOLE; NATAMYCIN;

ADULT; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; CLADOSPORIUM; CLINICAL ARTICLE; CONTROLLED STUDY; CURVULARIA; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLLOW UP; FUSARIUM; HUMAN; KERATITIS; KERATOMYCOSIS; MALE; MONOTHERAPY; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; ANTIFUNGAL AGENTS; CORNEA; CORNEAL ULCER; DRUG THERAPY, COMBINATION; ECONAZOLE; EYE INFECTIONS, FUNGAL; FEMALE; FUNGI; HUMANS; MALE; NATAMYCIN; OPHTHALMIC SOLUTIONS;

EID: 7444253370     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ico.0000134193.64357.82     Document Type: Article

References (18)

1. Srinivasan M, Gonzales CA, George C, et al. Epidemiology and etiological diagnosis of corneal ulceration in Madurai, South India. Br J Ophthalmol. 1997;81:965-971.
2. Gonzales CA, Srinivasan M, Whitcher JP, et al. Incidence of corneal ulceration in Madurai District, south India. Ophthalmic Epidemiol. 1996;3:159-166.
3. Rapoza PA, West SK, Katala SJ, et al. Prevalence and causes of vision loss in central Tanzania. Int Ophthalmol. 1991;15:123-129.
4. Brilliant LB, Pokhrel RP, Grasset NC, et al. Epidemiology of blindness in Nepal. Bull WHO. 1985;63:375-386.
5. Khan MU, Hague MR, Khan MR. Prevalence and causes of blindness in rural Bangladesh. Ind J Med Res. 1985;82:257-262.
6. Gilbert CE, Wood M, Waddel K, et al. Causes of childhood blindness in East Africa: results in 491 pupils attending 17 schools for the blind in Malawi, Kenya and Uganda. Ophthalmic Epidemiol. 1995;2:77-84.
7. Chirambo MC, Tielsch JM, West KP, et al. Blindness and visual impairment in southern Malawi. Bull WHO. 1986;64:567-572.
8. Hagan M, Wright E, Newman M, et al. Causes of suppurative keratitis in Ghana. Br J Ophthalmol. 1995;79:1024-1028.
9. Prajna NV, John RK, Nirmalan PK, et al. A randomized clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis. Br J Ophthalmol. 2003;87:1235-1237.
10. Medoff G, Kobayaski GS. Strategies in the treatment of systemic fungal infections. N Engl J Med. 1980;302:145-155.
11. Sud IJ, Feingold DS. Mechanism of action of the anti-mycotic imidazoles. J Invest Dermatol. 1981;6:438-441.
12. Searl SS, Udell IJ, Sadun A, et al. Aspergillus keratitis with intraocular invasion. Ophthalmology. 1981;88:1244-1250.
13. Komadina TG, Wilkes TD, Shock JP, et al. Treatment of Aspergillus fumigatus keratitis in rabbits with oral and topical ketoconazole. Am J Ophthalmol. 1985;99:476-479.
14. Fitzsimons R, Peters AL. Miconazole and ketoconazole as a satisfactory first line treatment for keratomycosis. Am J Opthalmol. 1986;101:605-608.
15. Beggs WH. Mechanisms of synergistic interactions between amphotericin B and flucytosine. J Antimicrob Chemother. 1986;17:402-404.
16. Johns KJ, O'Day DM. Pharmacologic management of keratomycoses. Surv Ophthalmol. 1988;33:178-188.
17. Alfonso EC, Rosa RH. Fungal keratitis. In Krachmer JH, Mannis MJ, Hooland EJ, eds. Cornea, Vol III. St Louis: Mosby, 1997:1253-1265.
18. Jones DB, Sexton R, Rebell G. Mycotic keratitis in south Florida: a review of thirty nine cases. Trans Ophthalmol Soc UK. 1970;89:781-797.