Low-density lipoprotein inhibits receptor-mediated prostaglandin synthesis without affecting calcium and arachidonic acid mobilization in human endothelial cells

Journal of Cardiovascular Pharmacology

Volumn 44, Issue 5, 2004, Pages 607-614

  Kilbourne, Edward J ^a  

^a PFIZER INC   (United States)

Author keywords

Endothelial cells; Low density lipoprotein; Prostaglandin; Serotonin

Indexed keywords

5 CARBAMOYLTRYPTAMINE; 6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; CALCIUM; HISTAMINE; LOW DENSITY LIPOPROTEIN; PROSTACYCLIN DERIVATIVE; PROSTAGLANDIN; PROSTAGLANDIN F2 ALPHA; SEROTONIN RECEPTOR;

AORTA; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

6-KETOPROSTAGLANDIN F1 ALPHA; AORTA; ARACHIDONIC ACID; CALCIUM; CELLS, CULTURED; CULTURE MEDIA; CYCLIC AMP; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENDOTHELIAL CELLS; HISTAMINE; HUMANS; LIPOPROTEINS, LDL; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; TIME FACTORS;

EID: 7444228487     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200411000-00015     Document Type: Article

References (34)

1. 1-like receptors mediating vasoconstriction and vasodilatation: their characterization and distribution in the intact canine cardiovascular system. Br J Pharmacol. 1995;114:961-968.
2. Ullmer C, Schmuck K, Kalkman HO, et al. Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 1995;370:215-221.
3. Shimokawa H, Flavahan NA, Vanhourte PM. Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. Circulation. 1991;83:652-660.
4. 1Dβ receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina. Chest. 1998;113:243-244.
5. McFadden EP, Clarke JG, Davies GJ, et al. Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. N Engl J Med. 1991;324:648-654.
6. Golino P, Piscione F, Willerson JT, et al. Divergent effects of serotonin on coronary artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. N Engl J Med. 1991;324:641-648.
7. Liao JK. Inhibition of Gi proteins by low density lipoprotein attenuates bradykinin-stimulated release of endothelial-derived nitric oxide. J Biol Chem. 1994;269:12987-12992.
8. Freeman JE, Kuo WY, Drenger B, et al. Analysis of lysophosphatidylcholine-inducedendothelial dysfunction. J Cardiovasc Pharmacol. 1996;28:345-352.
9. Parhami F, Fang ZT, Yang B, et al. Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL. Arterioscler Thromb Vasc Biol. 1995;15:2019-2024.
10. Ishida T, Kawashima S, Hirata K, et al. Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries. Circulation. 2001;103:1289-1295.
11. 1-like receptors mediate 5-hydroxytryptamine-induced contraction of the guinea-pig isolated iliac artery. Br J Pharmacol. 1991;102:386-390.
12. Yildiz O, Tuncer M. Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery. J Cardiovasc Pharmacol. 1995;25: 508-510.
13. 2 receptor-mediated contraction of the rabbit isolated femoral artery. Br J Pharmacol. 1992;107:418-421.
14. Tadipatri S, van Heuven-Nolsen D, Feniuk W, et al. Analysis of the 5-HT receptors mediating contractions in the rabbit isolated renal artery. Br J Pharmacol. 1991;104:887-894.
15. 1-like receptor in rabbit renal artery. Eur J Pharmacol. 1993;231:469-472.
16. Kalsner S, Richards R. Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: A mechanism for coronary spasm. Science. 1984;233:1435-1437.
17. Forman MB, Dates JA, Robertson D, et al. Increased adventital mast cells in a patient with coronary spasm. N Engl J Med. 1985;313:1138-1141.
18. Sakata Y, Komamura K, Hirayama A, et al. Elevation of the plasma histamine concentration in the coronary circulation in patients with variant angina. Am J Cardiol. 1996;77:1121-1126.
19. Laine P, Kaartinen M, Penttila A, et al. Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery. Circulation. 1999;99:361-369.
20. 1 receptors potentiate histamine and thrombin stimulated prostaglandin synthesis in endothelial cells. Thromb Haemost. 2001;85:924-928.
21. Hendriksen T, Mahoney EM, Steinberg D. Enhance macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci USA. 1981;78:6499-6503.
22. Morel DW, DiCorleto PE, Chisolm GM. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis. 1984;4:357-364.
23. Simon BC, Cunningham LD, Cohen RA. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest. 1990;86:75-79.
24. 2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. Br J Pharmacol. 1996;117:1081-1088.
25. Fujimoto M, Sakata T, Tsuruta Y, et al. Enhancement of bradykinin-induced prostacyclin synthesis in porcine aortic endothelial cells by pertussis toxin. Biochem Pharm. 1990;40:2661-2670.
26. Tanner FC, Noll G, Boulanger CM, et al. Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Circulation. 1991;83:2012-2020.
27. Hein T, Kuo L. LDLs impair vasomotor function of the coronary micro-circulation. Circ Res. 1998;83:404-414.
28. Ohgushi M, Kugiyama K, Fukunaga K, et al. Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL. Arterioscler Thromb. 1993;13:1525-1532.
29. Kugiyama K, Ohgushi M, Sugiyama S, et al. Lysophosphatidylcholine inhibits surface receptor-mediated intracellular signals in endothelial cells by a pathway involving protein kinase C activation. Circ Res. 1992;71: 1422-1428.
30. Honda HM, Leitinger N, Frankel M, et al. Induction of monocyte binding to endothelial cells by MM-LDL. Arterioscler Thromb Vasc Biol. 1999; 19:680-686.
31. Revtyak GE, Johnson AR, Campbell WB. Cultured bovine coronary arterial endothelial cells synthesize HETEs and prostacyclin. Am J Physiol 1988;254:8-19.
32. Maclouf J, Folco G, Patrono C. Eicosanoids and iso-eicosanoids: constitutive, inducible and transcellular biosynthesis in vascular disease. Thromb Haemost. 1998;79:691-705.
33. Yamaja Setty BN, Stuart MJ. 15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase. J Clin Invest. 1986;77: 202-211.
34. Moncada S, Gryglewski RJ, Bunting S, et al. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins. 1976;12:715-737.