Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: Results of a randomized, double-blind, vehicle-controlled trial

British Journal of Dermatology

Volumn 162, Issue 2, 2010, Pages 435-441

  Kimball, A B ^a   Kaczvinsky, J R ^b   Li, J ^b   Robinson, L R ^b   Matts, P J ^b   Berge, C A ^b   Miyamoto, K ^b   Bissett, D L ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Anti ageing; Hyperpigmentation; N acetyl glucosamine; Niacinamide; Randomized controlled trial

Indexed keywords

AVOBENZONE; MELANIN; N ACETYLGLUCOSAMINE; NICOTINAMIDE; SUNSCREEN;

ADULT; ARTICLE; CHROMATOPHORE; CLINICAL TRIAL; COMPUTER ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; FACE; FEMALE; HUMAN; HYPERPIGMENTATION; IMAGE ANALYSIS; LOTION; MAJOR CLINICAL STUDY; MEDICAL PHOTOGRAPHY; MORNING DOSAGE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN COLOR; SKIN IRRITATION; TREATMENT OUTCOME;

ACETYLGLUCOSAMINE; ADMINISTRATION, TOPICAL; ADULT; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FACE; FEMALE; GLUCOSAMINE; HUMANS; HYPERPIGMENTATION; IMAGE PROCESSING, COMPUTER-ASSISTED; MIDDLE AGED; NIACINAMIDE; SKIN PIGMENTATION; STATISTICS AS TOPIC; TREATMENT OUTCOME; VEHICLES;

EID: 74349127319     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09477.x     Document Type: Article

References (25)

1. Fink B, Grammer K, Matts P. Visible skin colour distribution plays a role in the perception of age, attractiveness, and health in female faces. Evol Human Behav 2006 27 : 433 442.
2. US Department of Health and Human Services. Skin Bleaching Drug Products for Over-the-Counter Human Use Proposed Rule. 21 CFR Part 310, 2006. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/E6-14263.htm (last accessed 25 August 2009).
3. Matts PJ, Oblong JE, Bissett DL. A review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag 2002 5 : 285 289.
4. Bissett DL, Oblong JE, Saud A et al. Topical niacinamide provides skin aging appearance benefits while enhancing barrier function. J Clin Dermatol 2003 32S : 9 18.
5. Bissett DL, Miyamoto K, Sun P et al. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci 2004 26 : 231 238.
6. Hakozaki T, Minwalla L, Zhuang J et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol 2003 147 : 20 31.
7. Greatens A, Hakozaki T, Koshoffer A et al. Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible. Exp Dermatol 2005 14 : 498 508.
8. Weindl G, Schaller M, Schafer-Korting M, Korting HC. Hyaluronic acid in the treatment and prevention of skin diseases: molecular, biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol 2004 17 : 207 213.
9. Sayo T, Sakai S, Inoue S. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes. Skin Pharmacol Physiol 2004 17 : 77 83.
10. Ghersetich I, Lotti T, Campanile G et al. Hyaluronic acid in cutaneous aging. Int J Dermatol 1994 33 : 119 122.
11. Imokawa G, Mishima Y. Importance of glycoproteins in the initiation of melanogenesis: an electron microscopic study of B-16 melanoma cells after release from inhibition of glycosylation. J Invest Dermatol 1986 87 : 319 325.
12. Mishima Y, Imokawa G. Selective aberration and pigment loss in melanosomes of malignant melanoma cells in vitro by glycosylation inhibitors: premelanosomes as glycoprotein. J Invest Dermatol 1983 81 : 106 114.
13. Imokawa G, Mishima Y. Loss of melanogenic properties in tyrosinases induced by glycosylation inhibitors within malignant melanoma cells. Cancer Res 1982 42 : 1994 2002.
14. Bissett D, McPhail S. Topical N-acetyl glucosamine affects pigmentation-relevant genes in in vitro genomics testing. Pigment Cell Res 2006 19 : 373 (Abstract PP-05).
15. Bissett D, Robinson L. Topical sugar amine reduces the appearance of hyperpigmented spots on human dorsal forearm and facial skin. Pigment Cell Res 2006 19 : 376 (Abstract PP-019).
16. Bissett D, Robinson L, Li J et al. Topical N-acetyl glucosamine reduces the appearance of hyperpigmented spots on human facial skin. J Am Acad Dermatol 2006 54 3 Suppl. 1 AB43 (Abstract P236).
17. Bissett DL, Robinson LR, Raleigh PS et al. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol 2007 6 : 20 6.
18. Miyamoto K, Takiwaki H, Hillebrand GG, Arase S. Development of a digital imaging system for objective measurement of hyperpigmented spots on the face. Skin Res Technol 2002 8 : 227 235.
19. Preece S, Cotton SD, Claridge E. Imaging the pigments of skin with a technique which is invariant to changes in surface geometry and intensity of illuminating light. In : Proceedings of Medical Image Understanding and Analysis (Barber D, ed.). Malvern : British Machine Vision Association, 2003 145 148.
20. Matts PJ, Dykes PJ, Marks R. The distribution of melanin in skin determined in vivo. Br J Dermatol 2007 156 : 620 628.
21. National Weather Service. Climate Prediction Center. UV Index: Annual Time Series. Daily UV Index, Indianapolis, IN, 2005. Available at: http://www.cpc.ncep.noaa.gov/products/stratosphere/uv-index/gif-files/ind-05. png (last accessed 25 August 2009).
22. National Weather Service. Climate Prediction Center. UV Index Bulletins Archives. Archive of UV Index Bulletins from Initial Date: June 28, 1994. Available at: http://www.cpc.ncep.noaa.gov/products/stratosphere/uv-index/uv- archive.shtml (last accessed 25 August 2009).
23. Kim EH, Kim YC, Lee ES, Kang HY. The vascular characteristics of melasma. J Dermatol Sci 2007 46 : 111 116.
24. Osborne R, Mullins L, Robinson L. Topical N-acetyl glucosamine and niacinamide increase hyaluronan in vitro. J Am Acad Dermatol 2006 54 3 Suppl. 1 AB106 (Abstract P1124).
25. Kikuchi K, Matahira Y. Oral N-acetylglucosamine supplementation improves skin conditions of female volunteers: clinical evaluation by a microscopic three-dimensional skin surface analyzer. J Appl Cosmetol 2002 20 : 143 152.