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Volumn 63, Issue 6, 2009, Pages 299-304

Significance of des-gamma-carboxy prothrombin production in hepatocellular carcinoma

Author keywords

Angiogenesis; Cell proliferation; Des carboxy prothrombin; Hepatocellular carcinoma; Signaling pathway

Indexed keywords

BIOLOGICAL MARKER; DECARBOXYPROTHROMBIN; GLUTAMYL CARBOXYLASE; LIGASE; PROTEIN PRECURSOR; PROTHROMBIN; SIGNAL PEPTIDE; TUMOR MARKER;

EID: 74349126580     PISSN: 0386300X     EISSN: 0386300X     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (28)

References (60)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB and Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology (2007) 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 67449104619 scopus 로고    scopus 로고
    • Highlights of regional meeting of Italian Southern Oncological Group (GOIM): focus on hepatocellular carcinoma: biological and clinical background, therapeutic guide-lines and perspectives
    • 7 November 2008, Naples, Italy
    • Addeo R, Caraglia M and Del Prete S: Highlights of regional meeting of Italian Southern Oncological Group (GOIM): focus on hepatocellular carcinoma: biological and clinical background, therapeutic guide-lines and perspectives. 7 November 2008, Naples, Italy. Expert Opin Investig Drugs (2009) 18: 373-378.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 373-378
    • Addeo, R.1    Caraglia, M.2    Del Prete, S.3
  • 3
    • 74349110708 scopus 로고    scopus 로고
    • Modalities of prevention of recurrence after tumor ablation/resection of HCC
    • Omata M: Modalities of prevention of recurrence after tumor ablation/resection of HCC. J Gastroenterol Hepatol (2004) 19: S270.
    • (2004) J Gastroenterol Hepatol , vol.19
    • Omata, M.1
  • 4
    • 68149141442 scopus 로고    scopus 로고
    • Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma
    • Hussain K and El-Serag HB: Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma. Minerva Gastroenterol Dietol (2009)55: 123-138.
    • (2009) Minerva Gastroenterol Dietol , vol.55 , pp. 123-138
    • Hussain, K.1    El-Serag, H.B.2
  • 5
    • 0034223661 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • discussion 1098-1102
    • Nakakura EK and Choti MA: Management of hepatocellular carcinoma. Oncology (Williston Park) (2000) 14: 1085-1098; discussion 1098-1102.
    • (2000) Oncology Williston Park , vol.14 , pp. 1085-1098
    • Nakakura, E.K.1    Choti, M.A.2
  • 8
    • 0029261909 scopus 로고
    • Hepatocellular carcinoma: update on diagnosis and treatment
    • Ramsey WH and Wu GY: Hepatocellular carcinoma: update on diagnosis and treatment. Dig Dis (1995) 13: 81-91.
    • (1995) Dig Dis , vol.13 , pp. 81-91
    • Ramsey, W.H.1    Wu, G.Y.2
  • 9
    • 0034033231 scopus 로고    scopus 로고
    • Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma
    • South Tohoku District Study Group
    • Ishii M, Gama H, Chida N, Ueno Y, Shinzawa H, Takagi T, Toyota T, Takahashi T and Kasukawa R: Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma. South Tohoku District Study Group. Am J Gastroenterol (2000) 95: 1036-1040.
    • (2000) Am J Gastroenterol , vol.95 , pp. 1036-1040
    • Ishii, M.1    Gama, H.2    Chida, N.3    Ueno, Y.4    Shinzawa, H.5    Takagi, T.6    Toyota, T.7    Takahashi, T.8    Kasukawa, R.9
  • 10
    • 0035059885 scopus 로고    scopus 로고
    • Alphafetoprotein:an obituary
    • Sherman M: Alphafetoprotein:an obituary. J Hepatol (2001) 34: 603-605.
    • (2001) J Hepatol , vol.34 , pp. 603-605
    • Sherman, M.1
  • 11
    • 0036729893 scopus 로고    scopus 로고
    • How to detect hepatocellular carcinoma in cirrhosis
    • Ward J and Robinson PJ: How to detect hepatocellular carcinoma in cirrhosis. Eur Radiol (2002) 12: 2258-2272.
    • (2002) Eur Radiol , vol.12 , pp. 2258-2272
    • Ward, J.1    Robinson, P.J.2
  • 12
    • 0032745626 scopus 로고    scopus 로고
    • Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin
    • Uehara S, Gotoh K, Handa H, Honjo K and Hirayama A: Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin. Clin Chim Acta (1999) 289: 33-44.
    • (1999) Clin Chim Acta , vol.289 , pp. 33-44
    • Uehara, S.1    Gotoh, K.2    Handa, H.3    Honjo, K.4    Hirayama, A.5
  • 14
    • 0023882166 scopus 로고
    • Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma
    • Fujiyama S, Morishita T, Hashiguchi O and Sato T: Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma. Cancer (1988) 61: 1621-1628.
    • (1988) Cancer , vol.61 , pp. 1621-1628
    • Fujiyama, S.1    Morishita, T.2    Hashiguchi, O.3    Sato, T.4
  • 15
    • 0030004788 scopus 로고    scopus 로고
    • Usefulness of simultaneous determination of alpha-fetoprotein and des-gamma-carboxy prothrombin in hepato cellular carcinoma
    • Nakao A, Taniguchi K, Inoue S, Harada A, Nonami T, Watanabe K and Takagi H: Usefulness of simultaneous determination of alpha-fetoprotein and des-gamma-carboxy prothrombin in hepato cellular carcinoma. Semin Surg Oncol (1996) 12: 160-163.
    • (1996) Semin Surg Oncol , vol.12 , pp. 160-163
    • Nakao, A.1    Taniguchi, K.2    Inoue, S.3    Harada, A.4    Nonami, T.5    Watanabe, K.6    Takagi, H.7
  • 16
    • 33747415949 scopus 로고    scopus 로고
    • New frontiers in biomarkers for hepatocellular carcinoma
    • Giannelli G and Antonaci S: New frontiers in biomarkers for hepatocellular carcinoma. Dig Liver Dis (2006) 38: 854-859.
    • (2006) Dig Liver Dis , vol.38 , pp. 854-859
    • Giannelli, G.1    Antonaci, S.2
  • 17
    • 0034141402 scopus 로고    scopus 로고
    • Serum levels of des-gamma-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma
    • Okuda H, Nakanishi T, Takatsu K, Saito A, Hayashi N, Takasaki K, Takenami K, Yamamoto M and Nakano M: Serum levels of des-gamma-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma. Cancer (2000) 88: 544-549.
    • (2000) Cancer , vol.88 , pp. 544-549
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3    Saito, A.4    Hayashi, N.5    Takasaki, K.6    Takenami, K.7    Yamamoto, M.8    Nakano, M.9
  • 18
    • 0031736039 scopus 로고    scopus 로고
    • Serum des-gamma-carboxyprothrombin level by a modified enzyme immunoassay method in hepatocellular carcinoma: clinical significance in small hepatocellular carcinoma
    • Soga K, Watanabe T, Aikawa K, Toshima M, Shibasaki K and Aoyagi Y: Serum des-gamma-carboxyprothrombin level by a modified enzyme immunoassay method in hepatocellular carcinoma: clinical significance in small hepatocellular carcinoma. Hepatogastroenterology (1998) 45: 1737-1741.
    • (1998) Hepatogastroenterology , vol.45 , pp. 1737-1741
    • Soga, K.1    Watanabe, T.2    Aikawa, K.3    Toshima, M.4    Shibasaki, K.5    Aoyagi, Y.6
  • 19
    • 0035698289 scopus 로고    scopus 로고
    • Comparison of clinicopathological features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein alone and those seropositive for des-gamma-carboxy prothrombin alone
    • Okuda H, Nakanishi T, TakatsuK, Saito A, Hayashi N, Yamamoto M, Takasaki K and Nakano M: Comparison of clinicopathological features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein alone and those seropositive for des-gamma-carboxy prothrombin alone. J Gastroenterol Hepatol (2001) 16: 1290-1296.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 1290-1296
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3    Saito, A.4    Hayashi, N.5    Yamamoto, M.6    Takasaki, K.7    Nakano, M.8
  • 20
    • 0034177223 scopus 로고    scopus 로고
    • Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein
    • Hamamura K, Shiratori Y, Shiina S, Imamura M, Obi S, Sato S, Yoshida H and Omata M: Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein. Cancer (2000) 88: 1557-1564.
    • (2000) Cancer , vol.88 , pp. 1557-1564
    • Hamamura, K.1    Shiratori, Y.2    Shiina, S.3    Imamura, M.4    Obi, S.5    Sato, S.6    Yoshida, H.7    Omata, M.8
  • 21
    • 0027939329 scopus 로고
    • Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carcinoma
    • Inoue S, Nakao A, Harada A, Nonami T and Takagi H: Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carci noma. Am J Gastroenterol (1994) 89: 2222-2226.
    • (1994) Am J Gastroenterol , vol.89 , pp. 2222-2226
    • Inoue, S.1    Nakao, A.2    Harada, A.3    Nonami, T.4    Takagi, H.5
  • 22
    • 0029073320 scopus 로고
    • Des-gamma-carboxy prothrombin and proliferative activity of hepatocellular carcinoma
    • Suehiro T, Matsumata T, Itasaka H, Taketomi A, Yamamoto K and Sugimachi K: Des-gamma-carboxy prothrombin and proliferative activity of hepatocellular carcinoma. Surgery (1995) 117: 682-691.
    • (1995) Surgery , vol.117 , pp. 682-691
    • Suehiro, T.1    Matsumata, T.2    Itasaka, H.3    Taketomi, A.4    Yamamoto, K.5    Sugimachi, K.6
  • 23
    • 0032784523 scopus 로고    scopus 로고
    • Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma
    • Imamura H, Matsuyama Y, Miyagawa Y, Ishida K, Shimada R, Miyagawa S, Makuuchi M and Kawasaki S: Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma. Br J Surg (1999) 86: 1032-1038.
    • (1999) Br J Surg , vol.86 , pp. 1032-1038
    • Imamura, H.1    Matsuyama, Y.2    Miyagawa, Y.3    Ishida, K.4    Shimada, R.5    Miyagawa, S.6    Makuuchi, M.7    Kawasaki, S.8
  • 30
    • 0037411177 scopus 로고    scopus 로고
    • Survival and local recurrence rates of hepatocellular carcinoma patients treated by transarterial chemolipiodolization with and without embolization
    • Maeda S, Fujiyama S, Tanaka M, Ashihara H, Hirata R and Tomita K: Survival and local recurrence rates of hepatocellular carcinoma patients treated by transarterial chemolipiodolization with and without embolization. Hepatol Res (2002) 23: 202-210.
    • (2002) Hepatol Res , vol.23 , pp. 202-210
    • Maeda, S.1    Fujiyama, S.2    Tanaka, M.3    Ashihara, H.4    Hirata, R.5    Tomita, K.6
  • 31
    • 0026082855 scopus 로고
    • Clinical evaluation of plasma abnormal prothrombin (des-gamma-carboxy prothrombin) in hepatobiliary malignancies and other diseases
    • Nakao A, Suzuki Y, Isshiki K, KimuraY, Takeda S, Kishimoto W, Nonami T, Harada A and Takagi H: Clinical evaluation of plasma abnormal prothrombin (des-gamma-carboxy prothrombin) in hepatobiliary malignancies and other diseases. Am J astroenterol (1991) 86: 62-66.
    • (1991) Am J astroenterol , vol.86 , pp. 62-66
    • Nakao, A.1    Suzuki, Y.2    Isshiki, K.3    Kimura, Y.4    Takeda, S.5    Kishimoto, W.6    Nonami, T.7    Harada, A.8    Takagi, H.9
  • 32
    • 0036297393 scopus 로고    scopus 로고
    • Tumor markers in early diagnosis, follow-up and man agement of patients with hepatocellular carcinoma
    • Fujiyama S, Tanaka M, Maeda S, Ashihara H, Hirata R and Tomita K: Tumor markers in early diagnosis, follow-up and man agement of patients with hepatocellular carcinoma. Oncology (2002) 62 Suppl 1: 57-63.
    • (2002) Oncology , vol.62 SUPPL 1 , pp. 57-63
    • Fujiyama, S.1    Tanaka, M.2    Maeda, S.3    Ashihara, H.4    Hirata, R.5    Tomita, K.6
  • 33
    • 0029913526 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin and alpha-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma
    • Shimada M, Takenaka K, Fujiwara Y, Gion T, Kajiyama K, Maeda T, Shirabe K and Sugimachi K: Des-gamma-carboxy prothrombin and alpha-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma. Cancer (1996) 78: 2094-2100.
    • (1996) Cancer , vol.78 , pp. 2094-2100
    • Shimada, M.1    Takenaka, K.2    Fujiwara, Y.3    Gion, T.4    Kajiyama, K.5    Maeda, T.6    Shirabe, K.7    Sugimachi, K.8
  • 34
    • 37549061023 scopus 로고    scopus 로고
    • Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: a histopathological study of surgically resected hepatocellular carcinoma
    • Miyaaki H, Nakashima O, Kurogi M, Eguchi K and Kojiro M: Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: a histopathological study of surgically resected hepatocellular carcinoma. J Gastroenterol (2007) 42: 962-968.
    • (2007) J Gastroenterol , vol.42 , pp. 962-968
    • Miyaaki, H.1    Nakashima, O.2    Kurogi, M.3    Eguchi, K.4    Kojiro, M.5
  • 35
    • 0035253469 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients
    • Koike Y, Shiratori Y, Sato S, Obi S, Teratani T, Imamura M, Yoshida H, Shiina S and Omata M: Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients. Cancer (2001) 91: 561-569.
    • (2001) Cancer , vol.91 , pp. 561-569
    • Koike, Y.1    Shiratori, Y.2    Sato, S.3    Obi, S.4    Teratani, T.5    Imamura, M.6    Yoshida, H.7    Shiina, S.8    Omata, M.9
  • 38
    • 33746772985 scopus 로고    scopus 로고
    • Clinical features of hepatitis C virus-related hepatocellular carcinoma and their association with alpha-fetoprotein and protein induced by vitamin K absence or antagonist-ll
    • Yano Y, Yamashita F, Kuwaki K, Fukumori K, Kato O, Yamamoto H, Ando E, Tanaka M and Sata M: Clinical features of hepatitis C virus-related hepatocellular carcinoma and their association with alpha-fetoprotein and protein induced by vitamin K absence or antagonist-ll. Liver Int (2006) 26: 789-795.
    • (2006) Liver Int , vol.26 , pp. 789-795
    • Yano, Y.1    Yamashita, F.2    Kuwaki, K.3    Fukumori, K.4    Kato, O.5    Yamamoto, H.6    Ando, E.7    Tanaka, M.8    Sata, M.9
  • 39
    • 67651097586 scopus 로고    scopus 로고
    • Prognostic Values of alpha-fetoprotein and Protein Induced by Vitamin K Absence or Antagonit-ll in Hepatitis B Virus-related Hepatocellular Carcinoma: A Prospective Study
    • Kim HS, Park JW, Jang JS, Kim HJ, Shin WG, Kim KH, LeeJH, Kim HY and Jang MK: Prognostic Values of alpha-fetoprotein and Protein Induced by Vitamin K Absence or Antagonit-ll in Hepatitis B Virus-related Hepatocellular Carcinoma: A Prospective Study. J Clin Gastroenterol (2009) 43: 482-488.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 482-488
    • Kim, H.S.1    Park, J.W.2    Jang, J.S.3    Kim, H.J.4    Shin, W.G.5    Kim, K.H.6    Lee, J.H.7    Kim, H.Y.8    Jang, M.K.9
  • 40
    • 0026350808 scopus 로고
    • Cloning and expression of the cDNA for human gamma-glutamyl carboxylase
    • Wu SM, Cheung WF, Frazier D and Stafford DW: Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. Science (1991) 254: 1634-1636.
    • (1991) Science , vol.254 , pp. 1634-1636
    • Wu, S.M.1    Cheung, W.F.2    Frazier, D.3    Stafford, D.W.4
  • 41
    • 0026089487 scopus 로고
    • Identification and purification to near homogeneity of the vitamin K-dependent carboxylase
    • Wu SM, Morris DP and Stafford DW: Identification and purification to near homogeneity of the vitamin K-dependent carboxylase. Proc Natl Acad Sci USA (1991) 88: 2236-2240.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2236-2240
    • Wu, S.M.1    Morris, D.P.2    Stafford, D.W.3
  • 42
    • 0030590086 scopus 로고    scopus 로고
    • Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment
    • Liu Y, Nelson AN and Lipsky JJ: Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment. Biochem Biophys Res Commun (1996) 224: 549-554.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 549-554
    • Liu, Y.1    Nelson, A.N.2    Lipsky, J.J.3
  • 43
    • 0032581377 scopus 로고    scopus 로고
    • Cloning, structural organization, and transcriptional activity of the rat vitamin K-dependent gamma-glutamyl carboxylase gene
    • Romero EE, Deo R, Velazquez-Estades LJ and Roth DA: Cloning, structural organization, and transcriptional activity of the rat vitamin K-dependent gamma-glutamyl carboxylase gene. Biochem Biophys Res Commun (1998) 248: 783-788.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 783-788
    • Romero, E.E.1    Deo, R.2    Velazquez-Estades, L.J.3    Roth, D.A.4
  • 46
    • 0032535284 scopus 로고    scopus 로고
    • A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors
    • Brenner B, Sanchez-Vega B, Wu SM, Lanir N, Stafford DW and Solera J: A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors. Blood (1998) 92: 4554-4559.
    • (1998) Blood , vol.92 , pp. 4554-4559
    • Brenner, B.1    Sanchez-Vega, B.2    Wu, S.M.3    Lanir, N.4    Stafford, D.W.5    Solera, J.6
  • 47
    • 4143112300 scopus 로고    scopus 로고
    • Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors
    • Rost S, Fregin A, Koch D, Compes M, Muller CR and Oldenburg J: Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors. Br J Haematol (2004) 126: 546-549.
    • (2004) Br J Haematol , vol.126 , pp. 546-549
    • Rost, S.1    Fregin, A.2    Koch, D.3    Compes, M.4    Muller, C.R.5    Oldenburg, J.6
  • 48
    • 0034669988 scopus 로고    scopus 로고
    • Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors
    • Spronk HM, Farah RA, Buchanan GR, Vermeer C and Soute BA: Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors. Blood (2000) 96: 3650-3652.
    • (2000) Blood , vol.96 , pp. 3650-3652
    • Spronk, H.M.1    Farah, R.A.2    Buchanan, G.R.3    Vermeer, C.4    Soute, B.A.5
  • 49
    • 0026526944 scopus 로고
    • Nucleotide sequence of prothrombin gene in abnormal prothrombin-producing hepatocellular carcinoma cell lines
    • Tagawa M, Omata M and Ohto M: Nucleotide sequence of prothrombin gene in abnormal prothrombin-producing hepatocellular carcinoma cell lines. Cancer (1992) 69: 643-647.
    • (1992) Cancer , vol.69 , pp. 643-647
    • Tagawa, M.1    Omata, M.2    Ohto, M.3
  • 53
    • 0027442005 scopus 로고
    • Substrate recognition by the vitamin K-dependent gamma-glutamyl carboxylase: identification of a sequence homology between the carboxylase and the carboxylase recognition site in the substrate
    • Price PA and Williamson MK: Substrate recognition by the vitamin K-dependent gamma-glutamyl carboxylase: identification of a sequence homology between the carboxylase and the carboxylase recognition site in the substrate. Protein Sci (1993) 2: 1987-1988.
    • (1993) Protein Sci , vol.2 , pp. 1987-1988
    • Price, P.A.1    Williamson, M.K.2
  • 54
    • 0035861747 scopus 로고    scopus 로고
    • Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity
    • Pudota BN, Hommema EL, Hallgren KW, McNally BA, Lee S and Berkner KL: Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity. J Biol Chem (2001) 276: 46878-46886.
    • (2001) J Biol Chem , vol.276 , pp. 46878-46886
    • Pudota, B.N.1    Hommema, E.L.2    Hallgren, K.W.3    McNally, B.A.4    Lee, S.5    Berkner, K.L.6
  • 55
    • 0026541633 scopus 로고
    • Changes of plasma des-gamma-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K
    • Furukawa M, Nakanishi T, Okuda H, Ishida S and Obata H: Changes of plasma des-gamma-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K. Cancer (1992) 69: 31-38.
    • (1992) Cancer , vol.69 , pp. 31-38
    • Furukawa, M.1    Nakanishi, T.2    Okuda, H.3    Ishida, S.4    Obata, H.5
  • 56
    • 0023243522 scopus 로고
    • Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. A clinical and experimental study
    • Okuda H, Obata H, Nakanishi T, Furukawa R and Hashimoto E: Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. A clinical and experimental study. J Hepatol (1987) 4: 357-363.
    • (1987) J Hepatol , vol.4 , pp. 357-363
    • Okuda, H.1    Obata, H.2    Nakanishi, T.3    Furukawa, R.4    Hashimoto, E.5
  • 57
    • 0027055456 scopus 로고
    • Relationship between patho logic prognostic factors and abnormal levels of des-gamma-carboxy prothrombin and alpha-fetoprotein in hepatocellular carcinoma
    • Sakon M, Monden M, Gotoh M, Kanai T, Umeshita K, Nakano Y, Mori T, Sakurai M and Wakasa K: Relationship between patho logic prognostic factors and abnormal levels of des-gamma-carboxy prothrombin and alpha-fetoprotein in hepatocellular carcinoma. Am J Surg(1992) 163: 251-256.
    • (1992) Am J Surg , vol.163 , pp. 251-256
    • Sakon, M.1    Monden, M.2    Gotoh, M.3    Kanai, T.4    Umeshita, K.5    Nakano, Y.6    Mori, T.7    Sakurai, M.8    Wakasa, K.9


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