Effect of simvastatin on glioma cell proliferation, migration, and apoptosis

Neurosurgery

Volumn 65, Issue 6, 2009, Pages 1087-1097

  Wu, Hongtao ^a   Jiang, Hao ^b   Lu, Dunyue ^c   Xiong, Ye ^a   Qu, Changsheng ^a   Zhou, Dong ^d   Mahmood, Asim ^a   Chopp, Michael ^b,e  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d SICHUAN UNIVERSITY   (China)

^e OAKLAND UNIVERSITY   (United States)

Author keywords

Apoptosis; Glioma; Lipid rafts; Phosphatidylinositol 3 kinase; PI3K Akt pathway; Simvastatin

Indexed keywords

CASPASE 3; CAVEOLIN 1; CHOLESTEROL; FAS ANTIGEN; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SIMVASTATIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GLIOMA CELL; HUMAN; HUMAN CELL; LIPID RAFT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; ANNEXIN A5; ANTICHOLESTEREMIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLIOMA; HUMANS; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIMVASTATIN; TIME FACTORS;

EID: 74349088838     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000360130.52812.1D     Document Type: Article

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