Matrix deactivation: A general approach to improve stability of unstable and reactive pharmaceutical genotoxic impurities for trace analysis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 1, 2010, Pages 30-36

  Sun, Mingjiang ^a   Bai, Lin ^a   Terfloth, Gerald J ^a   Liu, David Q ^a   Kord, Alireza S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Drug substance; Genotoxic impurity; Matrix deactivation; Solution stability; Trace analysis

Indexed keywords

1 METHYL 2 PYRROLIDINONE; ACETIC ACID; ACETONITRILE; ANTIOXIDANT; BENZOIC ACID; CHELATING AGENT; CHLORMETHINE DERIVATIVE; CHLOROFORMIC ACID ETHYL ESTER; DIMETHYLAMINE; FORMIC ACID; NUCLEOPHILE; PROTON;

ACCURACY; ALKYLATION; ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DERIVATIZATION; DILUTION; DRUG IMPURITY; DRUG MANUFACTURE; DRUG STABILITY; ELIMINATION REACTION; GAS CHROMATOGRAPHY; GENOTOXICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL; PROTON TRANSPORT; SENSITIVITY AND SPECIFICITY;

ALKYLATING AGENTS; CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUG STABILITY; FREE RADICAL SCAVENGERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROGEN-ION CONCENTRATION; MUTAGENS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TECHNOLOGY, PHARMACEUTICAL;

EID: 74249109087     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.11.027     Document Type: Article

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