Effectiveness and safety of splenectomy for gastric carcinoma: A meta-analysis

World Journal of Gastroenterology

Volumn 15, Issue 42, 2009, Pages 5352-5359

  Yang, Kun ^a   Chen, Xin Zu ^a   Hu, Jian Kun ^a   Zhang, Bo ^a   Chen, Zhi Xin ^a   Chen, Jia Ping ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Gastric cancer; Morbidity; Operative surgical procedure; Postoperative period; Splenectomy; Survival rate; Treatment outcome

Indexed keywords

ARTICLE; CANCER MORTALITY; CANCER PATIENT; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; GASTRECTOMY; HOSPITALIZATION; HUMAN; META ANALYSIS; MORBIDITY; OVERALL SURVIVAL; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; SPLENECTOMY; STOMACH CARCINOMA; SYSTEMATIC REVIEW;

EID: 74249106723     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.5352     Document Type: Article

References (72)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics, 2008. CA Cancer J Clin 2008; 58: 71-96
2. Blot WJ, Devesa SS, Kneller RW, Fraumeni JF Jr. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991; 265: 1287-1289
3. Powell J, McConkey CC. Increasing incidence of adenocarcinoma of the gastric cardia and adjacent sites. Br J Cancer 1990; 62: 440-443
4. Mönig SP, Collet PH, Baldus SE, Schmackpfeffer K, Schröder W, Thiele J, Dienes HP, Hölscher AH. Splenectomy in proximal gastric cancer: frequency of lymph node metastasis to the splenic hilus. J Surg Oncol 2001; 76: 89-92
5. Roder JD, Böttcher K, Siewert JR, Busch R, Hermanek P, Meyer HJ. Prognostic factors in gastric carcinoma. Results of the German Gastric Carcinoma Study 1992. Cancer 1993; 72: 2089-2097
6. Toge T, Kameda A, Kuroi K, Seto Y, Yamada H, Hattori T. [The role of the spleen in immunosuppression and the effects of splenectomy on prognosis in gastric cancer patients] Nippon Geka Gakkai Zasshi 1985; 86: 1120-1123
7. Orita K, Konaga E, Okada T, Kunisada K, Yumura M, Tanaka S. Effect of splenectomy in tumor-bearing mice and gastric cancer patients. Gann 1977; 68: 731-736
8. Kasakura Y, Fujii M, Mochizuki F, Kochi M, Kaiga T. Is there a benefit of pancreaticosplenectomy with gastrectomy for advanced gastric cancer? Am J Surg 2000; 179: 237-242
9. Saji S, Sakamoto J, Teramukai S, Kunieda K, Sugiyama Y, Ohashi Y, Nakazato H. Impact of splenectomy and immunochemotherapy on survival following gastrectomy for carcinoma: covariate interaction with immunosuppressive acidic protein, a serum marker for the host immune system. Tumor Marker Committee for the Study Group of Immunochemotherapy with PSK for Gastric Cancer. Surg Today 1999; 29: 504-510
10. Wanebo HJ, Kennedy BJ, Winchester DP, Stewart AK, Fremgen AM. Role of splenectomy in gastric cancer surgery: adverse effect of elective splenectomy on longterm survival. J Am Coll Surg 1997; 185: 177-184
11. Lockwood CM. Immunological functions of the spleen. Clin Haematol 1983; 12: 449-465
12. Llende M, Santiago-Delpín EA, Lavergne J. Immunobiological consequences of splenectomy: a review. J Surg Res 1986; 40: 85-94
13. Bonenkamp JJ, Hermans J, Sasako M, van de Velde CJ, Welvaart K, Songun I, Meyer S, Plukker JT, Van Elk P, Obertop H, Gouma DJ, van Lanschot JJ, Taat CW, de Graaf PW, von Meyenfeldt MF, Tilanus H. Extended lymph-node dissection for gastric cancer. N Engl J Med 1999; 340: 908-914
14. Cuschieri A, Fayers P, Fielding J, Craven J, Bancewicz J, Joypaul V, Cook P. Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial.The Surgical Cooperative Group. Lancet 1996; 347: 995-999
15. Bonenkamp JJ, Songun I, Hermans J, Sasako M, Welvaart K, Plukker JT, van Elk P, Obertop H, Gouma DJ, Taat CW. Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients. Lancet 1995; 345: 745-748
16. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998; 17: 2815-2834
17. Hosono S, Arimoto Y, Ohtani H, Kanamiya Y. Metaanalysis of short-term outcomes after laparoscopy-assisted distal gastrectomy. World J Gastroenterol 2006; 12: 7676-7683
18. NHS Centre for Reviews and Dissemination. Undertaking systematic reviews of research on effectiveness: CRD's guidance for carrying out or commissioning reviews (Report No 4). 2nd ed. York: NHS CRD, 2001
19. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557-560
20. Dixon E, Hameed M, Sutherland F, Cook DJ, Doig C. Evaluating meta-analyses in the general surgical literature: a critical appraisal. Ann Surg 2005; 241: 450-459
21. Nanthakumaran S, Fernandes E, Thompson AM, Rapson T, Gilbert FJ, Park KG. Morbidity and mortality rates following gastric cancer surgery and contiguous organ removal, a population based study. Eur J Surg Oncol 2005; 31: 1141-1144
22. Wu CW, Chang IS, Lo SS, Hsieh MC, Chen JH, Lui WY, Whang-Peng J. Complications following D3 gastrectomy: post hoc analysis of a randomized trial. World J Surg 2006; 30: 12-16
23. Biffi R, Chiappa A, Luca F, Pozzi S, Lo Faso F, Cenciarelli S, Andreoni B. Extended lymph node dissection without routine spleno-pancreatectomy for treatment of gastric cancer: low morbidity and mortality rates in a single center series of 250 patients. J Surg Oncol 2006; 93: 394-400
24. Roukos DH, Paraschou P, Lorenz M. Distal gastric cancer and extensive surgery: a new evaluation method based on the study of the status of residual lymph nodes after limited surgery. Ann Surg Oncol 2000; 7: 719-726
25. Furukawa H, Hiratsuka M, Ishikawa O, Ikeda M, Imamura H, Masutani S, Tatsuta M, Satomi T. Total gastrectomy with dissection of lymph nodes along the splenic artery: a pancreas-preserving method. Ann Surg Oncol 2000; 7: 669-673
26. Sano T, Martin IG. Lymphadenectomy and pancreaticosplenectomy in gastric cancer surgery. Lancet 1996; 348: 195-196
27. Kunisaki C, Makino H, Suwa H, Sato T, Oshima T, Nagano Y, Fujii S, Akiyama H, Nomura M, Otsuka Y, Ono HA, Kosaka T, Takagawa R, Ichikawa Y, Shimada H. Impact of splenectomy in patients with gastric adenocarcinoma of the cardia. J Gastrointest Surg 2007; 11: 1039-1044
28. Barry JD, Blackshaw GR, Edwards P, Lewis WG, Murphy P, Hodzovic I, Thompson IW, Allison MC. Western body mass indices need not compromise outcomes after modified D2 gastrectomy for carcinoma. Gastric Cancer 2003; 6: 80-85
29. Karaki Y, Fujimaki M, Yamada A, Katoh H, Hokari I, Sakamoto T. Surgical treatment of carcinoma of the esophagogastric junction. Int Surg 1991; 76: 205-208
30. Weitz J, D'Angelica M, Gonen M, Klimstra D, Coit DG, Brennan MF, Karpeh MS. Interaction of splenectomy and perioperative blood transfusions on prognosis of patients with proximal gastric and gastroesophageal junction cancer. J Clin Oncol 2003; 21: 4597-4603
31. Gao ZQ. Combined organ resection for treatment of advanced gastric cancer. Zhonghua Weichang Waike Zazhi 2003; 6: 123
32. Kitamura K, Nishida S, Ichikawa D, Taniguchi H, Hagiwara A, Yamaguchi T, Sawai K. No survival benefit from combined pancreaticosplenectomy and total gastrectomy for gastric cancer. Br J Surg 1999; 86: 119-122
33. Iriyama K, Ohsawa T, Tsuchibashi T, Noji M, Miki C, Ilunga K, Suzuki H. Results of combined resection of invaded organs in patients with potentially curable, advanced gastric cancer. Eur J Surg 1994; 160: 27-30
34. Maruyama K, Sasako M, Kinoshita T, Sano T, Katai H, Okajima K. Pancreas-preserving total gastrectomy for proximal gastric cancer. World J Surg 1995; 19: 532-536
35. Brady MS, Rogatko A, Dent LL, Shiu MH. Effect of splenectomy on morbidity and survival following curative gastrectomy for carcinoma. Arch Surg 1991; 126: 359-364
36. Erturk S, Ersan Y, Cicek Y, Dogusoy G, Senocak M. Effect of simultaneous splenectomy on the survival of patients undergoing curative gastrectomy for proximal gastric carcinoma. Surg Today 2003; 33: 254-258
37. Fatouros M, Roukos DH, Lorenz M, Arampatzis I, Hottentrott C, Encke A, Kappas AM. Impact of spleen preservation in patients with gastric cancer. Anticancer Res 2005; 25: 3023-3030
38. Griffith JP, Sue-Ling HM, Martin I, Dixon MF, McMahon MJ, Axon AT, Johnston D. Preservation of the spleen improves survival after radical surgery for gastric cancer. Gut 1995; 36: 684-690
39. Kodera Y, Yamamura Y, Shimizu Y, Torii A, Hirai T, Yasui K, Morimoto T, Kato T, Kito T. Lack of benefit of combined pancreaticosplenectomy in D2 resection for proximal-third gastric carcinoma. World J Surg 1997; 21: 622-627; discussion 627-628
40. Koga S, Kaibara N, Kimura O, Nishidoi H, Kishimoto H. Prognostic significance of combined splenectomy or pancreaticosplenectomy in total and proximal gastrectomy for gastric cancer. Am J Surg 1981; 142: 546-550
41. Kwon SJ. Prognostic impact of splenectomy on gastric cancer: results of the Korean Gastric Cancer Study Group. World J Surg 1997; 21: 837-844
42. Lee KY, Noh SH, Hyung WJ, Lee JH, Lah KH, Choi SH, Min JS. Impact of splenectomy for lymph node dissection on long-term surgical outcome in gastric cancer. Ann Surg Oncol 2001; 8: 402-406
43. Lu HM. The treatment value of total gastrectomy with splenectomy for gastric cancer. Nantong Yixueyuan Yuebao 2001; 21: 288
44. Maehara Y, Moriguchi S, Yoshida M, Takahashi I, Korenaga D, Sugimachi K. Splenectomy does not correlate with length of survival in patients undergoing curative total gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer 1991; 67: 3006-3009
45. Martin RC 2nd, Jaques DP, Brennan MF, Karpeh M. Extended local resection for advanced gastric cancer: increased survival versus increased morbidity. Ann Surg 2002; 236: 159-165
46. Otsuji E, Yamaguchi T, Sawai K, Ohara M, Takahashi T. End results of simultaneous splenectomy in patients undergoing total gastrectomy for gastric carcinoma. Surgery 1996; 120: 40-44
47. Schmid A, Thybusch A, Kremer B, Henne-Bruns D. Differential effects of radical D2-lymphadenectomy and splenectomy in surgically treated gastric cancer patients. Hepatogastroenterology 2000; 47: 579-585
48. Shiu MH, Perrotti M, Brennan MF. Adenocarcinoma of the stomach: a multivariate analysis of clinical, pathologic and treatment factors. Hepatogastroenterology 1989; 36: 7-12
49. Tamada R, Sugimachi K, Okamura T, Hiramoto Y, Notsuka T, Korenaga D, Inokuchi K. [Evaluation of splenectomy in total gastrectomy for gastric cancer] Nippon Geka Gakkai Zasshi 1985; 86: 1124-1127
50. Weitz J, Jaques DP, Brennan M, Karpeh M. Association of splenectomy with postoperative complications in patients with proximal gastric and gastroesophageal junction cancer. Ann Surg Oncol 2004; 11: 682-689
51. Yoshino K, Yamada Y, Asanuma F, Aizawa K. Splenectomy in cancer gastrectomy: recommendation of spleen-preserving for early stages. Int Surg 1997; 82: 150-154
52. Zhang CH, Zhan WH, He YL, Chen CQ, Huang MJ, Cai SR. Spleen preservation in radical surgery for gastric cardia cancer. Ann Surg Oncol 2007; 14: 1312-1319
53. Zhang J, Zhou YM. The option of spleen in D3 lymphadenectomy for gastric cancer (87 cases). Yixue Wenxuan 2000; 19: 484-485
54. Stipa S, Di Giorgio A, Ferri M, Botti C. Results of curative gastrectomy for carcinoma. J Am Coll Surg 1994; 179: 567-572
55. Chen JQ, Zhan WH, Cai SR, Lu YF. Effect of splenectomy combined with radical total gastrectomy on the survival of patients with proximal gastric carcinoma. Zhongguo Putong Waike Zazhi 2005; 14: 161-164
56. Han FH, Zhan WH, Li YM, He YL, Peng JS, Ma JP, Wang Z, Chen ZX, Zheng ZQ, Wang JP, Huang YH, Dong WG. [Analysis of long-term results of radical gastrectomy combining splenectomy for gastric cancer] Zhonghua Waike Zazhi 2005; 43: 1114-1117
57. Adachi Y, Kamakura T, Mori M, Maehara Y, Sugimachi K. Role of lymph node dissection and splenectomy in node-positive gastric carcinoma. Surgery 1994; 116: 837-841
58. Cho MY, Kroh MD, Joh YG, Suh SO. Impact of splenectomy on circulating T-lymphocyte subsets in stage III gastric cancer. ANZ J Surg 2002; 72: 411-416
59. Miwa H, Kojima K, Ono F, Kobayashi T, Tsurumi T, Hatosaki A, Iijima T, Orita K. Effect of splenectomy and immunotherapy on advanced gastric cancer associated with total gastrectomy. Jpn J Surg 1983; 13: 20-24
60. Suehiro S, Nagasue N, Ogawa Y, Sasaki Y, Hirose S, Yukaya H. The negative effect of splenectomy on the prognosis of gastric cancer. Am J Surg 1984; 148: 645-648
61. Sugimachi K, Kodama Y, Kumashiro R, Kanematsu T, Noda S, Inokuchi K. Critical evaluation of prophylactic splenectomy in total gastrectomy for the stomach cancer. Gann 1980; 71: 704-709
62. Suo J, Chen Y, Wang Q. Retrospective analysis of effectiveness of spleen preserving total gastrectomy for elderly patients with gastric cancer. Zhongguo Laonianxue Zazhi 2006; 26: 845-846
63. Csendes A, Burdiles P, Rojas J, Braghetto I, Diaz JC, Maluenda F. A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma. Surgery 2002; 131: 401-407
64. Yu W, Choi GS, Chung HY. Randomized clinical trial of splenectomy versus splenic preservation in patients with proximal gastric cancer. Br J Surg 2006; 93: 559-563
65. Maruyama K, Okabayashi K, Kinoshita T. Progress in gastric cancer surgery in Japan and its limits of radicality. World J Surg 1987; 11: 418-425
66. Maruyama K, Gunvén P, Okabayashi K, Sasako M, Kinoshita T. Lymph node metastases of gastric cancer. General pattern in 1931 patients. Ann Surg 1989; 210: 596-602
67. Sano T, Yamamoto S, Sasako M. Randomized controlled trial to evaluate splenectomy in total gastrectomy for proximal gastric carcinoma: Japan clinical oncology group study JCOG 0110-MF. Jpn J Clin Oncol 2002; 32: 363-364
68. Athanasiou T, Al-Ruzzeh S, Kumar P, Crossman MC, Amrani M, Pepper JR, Del Stanbridge R, Casula R, Glenville B. Off-pump myocardial revascularization is associated with less incidence of stroke in elderly patients. Ann Thorac Surg 2004; 77: 745-753
69. Ellison EC, Fabri PJ. Complications of splenectomy. Etiology, prevention, and management. Surg Clin North Am 1983; 63: 1313-1330
70. Okuno K, Tanaka A, Shigeoka H, Hirai N, Kawai I, Kitano Y, Yasutomi M. Suppression of T-cell function in gastric cancer patients after total gastrectomy with splenectomy: implications of splenic autotransplantation. Gastric Cancer 1999; 2: 20-25
71. Harrison LE, Karpeh MS, Brennan MF. Proximal gastric cancers resected via a transabdominal-only approach. Results and comparisons to distal adenocarcinoma of the stomach. Ann Surg 1997; 225: 678-683; discussion 683-685
72. Viste A, Haùgstvedt T, Eide GE, Søreide O. Postoperative complications and mortality after surgery for gastric cancer. Ann Surg 1988; 207: 7-13