Twist and shout: A clinical and experimental review of testicular torsion

Korean Journal of Urology

Volumn 50, Issue 12, 2009, Pages 1159-1167

  Ellati, Riyad T ^a   Kavoussi, Parviz K ^a   Turner, Terry T ^a   Lysiak, Jeffrey J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; Ischemia; Reperfusion; Testicular torsion; Testis

Indexed keywords

ANGIOPOIETIN; DEXAMETHASONE; MALONALDEHYDE; MIFEPRISTONE; MOLSIDOMINE; N(G) NITROARGININE METHYL ESTER; REACTIVE OXYGEN METABOLITE; SONIC HEDGEHOG PROTEIN; VASCULOTROPIN;

ANORCHIA; APOPTOSIS; COLOR ULTRASOUND FLOWMETRY; CRYPTORCHISM; ECHOGRAPHY; EMERGENCY SURGERY; EXTRAVAGINAL TORSION; FEVER; GERM CELL; HUMAN; INTRAVAGINAL TORSION; MALE INFERTILITY; NAUSEA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; ORCHIDOPEXY; ORCHIECTOMY; OUTCOME ASSESSMENT; REPERFUSION INJURY; REVIEW; SCROTAL PAIN; SIGNAL TRANSDUCTION; SPERMATIC CORD; SPERMATOGENESIS; TESTIS; TESTIS TORSION; TUNICA VAGINALIS; ULTRASOUND; VOMITING;

EID: 74249084930     PISSN: 20056737     EISSN: 20056745     Source Type: Journal    
DOI: 10.4111/kju.2009.50.12.1159     Document Type: Review

References (79)

1. Pentyala S, Lee J, Yalamanchili P, Vitkun S, Khan SA. Testicular torsion: a review. J Low Genit Tract Dis 2001;5: 38-47.
2. Ringdahl E, Teague L. Testicular torsion. Am Fam Physician 2006;74:1739-43.
3. Washowich TL. Synchronous bilateral testicular torsion in an adult. J Ultrasound Med 2001;20:933-5.
4. Nöske HD, Kraus SW, Altinkilic BM, Weidner W. Historical milestones regarding torsion of the scrotal organs. J Urol 1998; 159:13-6.
5. Eaton SH, Cendron MA, Estrada CR, Bauer SB, Borer JG, Cilento BG, et al. Intermittent testicular torsion: diagnostic features and management outcomes. J Urol 2005;174:1532-5.
6. Mor Y, Pinthus JH, Nadu A, Raviv G, Golomb J, Winkler H, et al. Testicular fixation following torsion of the spermatic cord - does it guarantee prevention of recurrent torsion events? J Urol 2006;175:171-3.
7. Dogra V, Bhatt S. Acute painful scrotum. Radiol Clin North Am 2004;42:349-63.
8. Dubinsky TJ, Chen P, Maklad N. Color-flow and power Doppler imaging of the testes. World J Urol 1998;16:35-40.
9. Luker GD, Siegel MJ. Scrotal US in pediatric patients: comparison of power and standard color Doppler US. Radiology 1996;198:381-5.
10. Watanabe Y, Nagayama M, Okumura A, Amoh Y, Suga T, Terai A, et al. MR imaging of testicular torsion: features of testicular hemorrhagic necrosis and clinical outcomes. J Magn Reson Imaging 2007;26:100-8.
11. Dogra VS, Gottlieb RH, Oka M, Rubens DJ. Sonography of the scrotum. Radiology 2003;227:18-36.
12. Dogra V. Bell-clapper deformity. AJR Am J Roentgenol 2003; 180:1176.
13. Backhouse KM. Embryology of testicular descent and maldescent. Urol Clin North Am 1982;9:315-25.
14. Hawtrey CE. Assessment of acute scrotal symptoms and findings. A clinician's dilemma. Urol Clin North Am 1998; 25:715-23.
15. Brown SM, Casillas VJ, Montalvo BM, Albores-Saavedra J. Intrauterine spermatic cord torsion in the newborn: sonographic and pathologic correlation. Radiology 1990;177:755-7.
16. Zilberman D, Inbar Y, Heyman Z, Shinhar D, Bilik R, Avigad I, et al. Torsion of the cryptorchid testis - can it be salvaged? J Urol 2006;175:2287-9.
17. Skoglund RW, McRoberts JW, Ragde H. Torsion of testicular appendages: presentation of 43 new cases and a collective review. J Urol 1970;104:598-600.
18. Lerner RM, Mevorach RA, Hulbert WC, Rabinowitz R. Color Doppler US in the evaluation of acute scrotal disease. Radiology 1990;176:355-8.
19. Yang DM, Lim JW, Kim JE, Kim JH, Cho H. Torsed appendix testis: gray scale and color Doppler sonographic findings compared with normal appendix testis. J Ultrasound Med 2005;24:87-91.
20. Turner TT. Acute experimental testicular torsion. No effect on the contralateral testis. J Androl 1985;6:65-72.
21. Turner TT, Brown KJ. Spermatic cord torsion: loss of spermatogenesis despite return of blood flow. Biol Reprod 1993;49:401-7.
22. Hadziselimovic F, Snyder H, Duckett J, Howards S. Testicular histology in children with unilateral testicular torsion. J Urol 1986;136:208-10.
23. Taskinen S, Taskinen M, Rintala R. Testicular torsion: orchiectomy or orchiopexy? J Pediatr Urol 2008;4:210-3.
24. Patriquin HB, Yazbeck S, Trinh B, Jequier S, Burns PN, Grignon A, et al. Testicular torsion in infants and children: diagnosis with Doppler sonography. Radiology 1993;188:781-5.
25. Mansbach JM, Forbes P, Peters C. Testicular torsion and risk factors for orchiectomy. Arch Pediatr Adolesc Med 2005;159:1167-71.
26. Hayn MH, Herz DB, Bellinger MF, Schneck FX. Intermittent torsion of the spermatic cord portends an increased risk of acute testicular infarction. J Urol 2008;180(4 Suppl):1729-32.
27. Guerra LA, Wiesenthal J, Pike J, Leonard MP. Management of neonatal testicular torsion: Which way to turn? Can Urol Assoc J 2008;2:376-9.
28. Al-Salem AH. Intrauterine testicular torsion: a surgical emergency. J Pediatr Surg 2007;42:1887-91.
29. Kaye JD, Shapiro EY, Levitt SB, Friedman SC, Gitlin J, Freyle J, et al. Parenchymal echo texture predicts testicular salvage after torsion: potential impact on the need for emergent exploration. J Urol 2008;180(4 Suppl):1733-6.
30. Janetschek G, Schreckenberg F, Grimm W, Marberger M. Hemodynamic effects of experimental testicular torsion. Urol Res 1987;15:303-6.
31. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-63.
32. Williamson RC. Torsion of the testis and allied conditions. Br J Surg 1976;63:465-76.
33. Workman SJ, Kogan BA. Old and new aspects of testicular torsion. Semin Urol 1988;6:146-57.
34. Lievano G, Nguyen L, Radhakrishnan J, Fornell L, John E. New animal model to evaluate testicular blood flow during testicular torsion. J Pediatr Surg 1999;34:1004-6.
35. Lysiak JJ, Turner SD, Nguyen QA, Singbartl K, Ley K, Turner TT. Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis. Biol Reprod 2001;65:718-25.
36. Lysiak JJ, Nguyen QA, Turner TT. Fluctuations in rat testicular interstitial oxygen tensions are linked to testicular vasomotion: persistence after repair of torsion. Biol Reprod 2000;63:1383-9.
37. Collin O, Bergh A, Damber JE, Widmark A. Control of testicular vasomotion by testosterone and tubular factors in rats. J Reprod Fertil 1993;97:115-21.
38. Turner TT, Caplis L, Miller DW. Testicular microvascular blood flow: alteration after Leydig cell eradication and ischemia but not experimental varicocele. J Androl 1996;17:239-48.
39. Shiraishi K, Naito K, Yoshida K. Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat. Biol Reprod 2001;65:514-21.
40. Ozturk H, Buyukbayram H, Ozdemir E, Ketani A, Gurel A, Onen A, et al. The effects of nitric oxide on the expression of cell adhesion molecules (ICAM-1, UEA-1, and tenascin) in rats with unilateral testicular torsion. J Pediatr Surg 2003;38:1621-7.
41. Kribben A, Edelstein CL, Schrier RW. Pathophysiology of acute renal failure. J Nephrol 1999;12(Suppl 2):S142-51.
42. Galley HF, Webster NR. Physiology of the endothelium. Br J Anaesth 2004;93:105-13.
43. Laroux FS, Lefer DJ, Kawachi S, Scalia R, Cockrell AS, Gray L, et al. Role of nitric oxide in the regulation of acute and chronic inflammation. Antioxid Redox Signal 2000;2:391-6.
44. Turner TT, Rhoades CP. Testicular capillary permeability: the movement of luteinizing hormone from the vascular to the interstitial compartment. J Androl 1995;16:417-23.
45. Baker LA, Turner TT. Leydig cell function after experimental testicular torsion despite loss of spermatogenesis. J Androl 1995;16:12-7.
46. Turner TT, Bang HJ, Lysiak JJ. Experimental testicular torsion: reperfusion blood flow and subsequent testicular venous plasma testosterone concentrations. Urology 2005;65:390-4.
47. Turner TT, Miller DW. On the synthesis and secretion of rat seminiferous tubule proteins in vivo after ischemia and germ cell loss. Biol Reprod 1997;57:1275-84.
48. Lysiak JJ, Bang HJ, Nguyen QA, Turner TT. Activation of the nuclear factor kappa B pathway following ischemia-reperfusion of the murine testis. J Androl 2005;26:129-35.
49. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-62.
50. Ravichandran KS. "Recruitment signals" from apoptotic cells: invitation to a quiet meal. Cell 2003;113:817-20.
51. Green DR. Apoptotic pathways: the roads to ruin. Cell 1998; 94:695-8.
52. Green DR, Beere HM. Apoptosis. Mostly dead. Nature 2001; 412:133-5.
53. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998;281:1322-6.
54. Matsui Y. Regulation of germ cell death in mammalian gonads. Apmis 1998;106:142-7.
55. Brinkworth MH, Weinbauer GF, Schlatt S, Nieschlag E. Identification of male germ cells undergoing apoptosis in adult rats. J Reprod Fertil 1995;105:25-33.
56. Yin Y, DeWolf WC, Morgentaler A. Experimental cryptorchidism induces testicular germ cell apoptosis by p53-dependent and -independent pathways in mice. Biol Reprod 1998;58:492-6.
57. Lysiak JJ, Turner SD, Turner TT. Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis. Biol Reprod 2000;63:1465-72.
58. Turner TT, Tung KS, Tomomasa H, Wilson LW. Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol Reprod 1997;57:1267-74.
59. Lysiak JJ, Zheng S, Woodson R, Turner TT. Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2. Cell Tissue Res 2007;328:411-9.
60. Zheng S, Turner TT, Lysiak JJ. Caspase 2 activity contributes to the initial wave of germ cell apoptosis during the first round of spermatogenesis. Biol Reprod 2006;74:1026-33.
61. Paroni G, Henderson C, Schneider C, Brancolini C. Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus. J Biol Chem 2002;277:15147-61.
62. Lassus P, Opitz-Araya X, Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 2002;297:1352-4.
63. Lysiak JJ, Nguyen QA, Kirby JL, Turner TT. Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression. Biol Reprod 2003;69:202-10.
64. Halliwell B. The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis 1993;23(Suppl 1):118-26.
65. Guha M, Bai W, Nadler JL, Natarajan R. Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and -independent pathways. J Biol Chem 2000;275:17728-39.
66. Read MA, Whitley MZ, Gupta S, Pierce JW, Best J, Davis RJ, et al. Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. J Biol Chem 1997;272:2753-61.
67. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-52.
68. Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line. Toxicol Appl Pharmacol 1999;161:111-22.
69. Carre PC, Mortenson RL, King TE Jr, Noble PW, Sable CL, Riches DW. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest 1991;88:1802-10.
70. Nes WD, Lukyanenko YO, Jia ZH, Quideau S, Howald WN, Pratum TK, et al. Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. Endocrinology 2000;141:953-8.
71. Yin J, Chaufour X, McLachlan C, McGuire M, White G, King N, et al. Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo. Atherosclerosis 2000;148:365-74.
72. Astruc M, Roussillon S, Defay R, Descomps B, Crastes de Paulet A. DNA and cholesterol biosynthesis in synchronized embryonic rat fibroblasts. II. Effects of sterol biosynthesis inhibitors on cell division. Biochim Biophys Acta 1983;763:11-8.
73. Lysiak JJ, Nguyen QA, Turner TT. Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion. J Androl 2002;23:400-9.
74. Turner TT, Bang HJ, Lysiak JL. The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair. J Urol 2004;172:2574-8.
75. Yazawa H, Sasagawa I, Suzuki Y, Nakada T. Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia. Fertil Steril 2001;75:980-5.
76. Ozokutan BH, Kücükaydin M, Muhtaroglu S, Tekin Y. The role of nitric oxide in testicular ischemia-reperfusion injury. J Pediatr Surg 2000;35:101-3.
77. Sahinkanat T, Ozkan KU, Tolun FI, Ciralik H, Imrek SS. The protective effect of ischemic preconditioning on rat testis. Reprod Biol Endocrinol 2007;5:47.
78. Akgül T, Karagüzel E, Sürer H, Yaǧmurdur H, Ayyildiz A, Ustün H, et al. Ginkgo biloba (EGB 761) affects apoptosis and nitric-oxide synthases in testicular torsion: an experimental study. Int Urol Nephrol 2009;41:531-6.
79. Dokucu AI, Ozturk H, Ozturk H, Tuncer MC, Yilmaz F. The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats. Int Urol Nephrol 2009;41:101-8.