Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan

Parkinsonism and Related Disorders

Volumn 16, Issue 1, 2010, Pages 28-30

  Chang, Ting Yu ^a   Kuo, Hung Chou ^a   Lu, Chin Song ^a   Wu Chou, Yah Huei ^a   Huang, Chin Chang ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Alzheimer's disease; Han Chinese; LRRK2

Indexed keywords

ARGININE; GLYCINE; LEUCINE RICH REPEAT KINASE 2;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CHINESE; CONTROLLED STUDY; EDUCATION; FEMALE; GENE MUTATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; TAIWAN; WILD TYPE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ARGININE; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLYCINE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TAIWAN;

EID: 74149088164     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2009.06.009     Document Type: Article

References (25)

1. Pericak-Vance M.A., Bass M.P., Yamaoka L.H., Gaskell P.C., Scott W.K., Terwedow H.A., et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 278 (1997) 1237-1241
2. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 (1993) 921-923
3. Waring S.C., and Rosenberg R.N. Genome-wide association studies in Alzheimer disease. Arch Neurol 65 (2008) 329-334
4. Tanzi R.E. A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. J Clin Invest 104 (1999) 1175-1179
5. Li Y., Nowotny P., Holmans P., Smemo S., Kauwe J.S., Hinrichs A.L., et al. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A 101 (2004) 15688-15693
6. Bertram L., Hiltunen M., Parkinson M., Ingelsson M., Lange C., Ramasamy K., et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 352 (2005) 884-894
7. Li Y., Grupe A., Rowland C., Nowotny P., Kauwe J.S., Smemo S., et al. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet 15 (2006) 2560-2568
8. Rogaeva E., Meng Y., Lee J.H., Gu Y., Kawarai T., Zou F., et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39 (2007) 168-177
9. Sundar P.D., Feingold E., Minster R.L., DeKosky S.T., and Kamboh M.I. Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease. Neurobiol Aging 28 (2007) 856-862
10. Di Fonzo A., Wu-Chou Y.H., Lu C.S., van Doeselaar M., Simons E.J., Rohe C.F., et al. A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan. Neurogenetics 7 (2006) 133-138
11. Fung H.C., Chen C.M., Hardy J., Singleton A.B., and Wu Y.R. A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan. BMC Neurol 6 (2006) 47
12. Tan E.K., Zhao Y., Skipper L., Tan M.G., Di Fonzo A., Sun L., et al. The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence. Hum Genet 120 (2007) 857-863
13. Li C., Ting Z., Qin X., Ying W., Li B., Guo Qiang L., et al. The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease. Mov Disord 22 (2007) 2439-2443
14. Zabetian C.P., Lauricella C.J., Tsuang D.W., Leverenz J.B., Schellenberg G.D., and Payami H. Analysis of the LRRK2 G2019S mutation in Alzheimer disease. Arch Neurol 63 (2006) 156-157
15. Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M., Lincoln S., et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44 (2004) 601-607
16. Hernandez D., Paisan Ruiz C., Crawley A., Malkani R., Werner J., Gwinn-Hardy K., et al. The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases. Neurosci Lett 389 (2005) 137-139
17. Toft M., Sando S.B., Melquist S., Ross O.A., White L.R., Aasly J.O., et al. LRRK2 mutations are not common in Alzheimer's disease. Mech Ageing Dev 126 (2005) 1201-1205
18. Tan E.K., Lee J., Chen C.P., Wong M.C., and Zhao Y. Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiol Aging 30 (2009) 501-502
19. Lu C.S., Chang H.C., Weng Y.H., Chen R.S., Bonifati V., and Wu-Chou Y.H. Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan. Parkinsonism Relat Disord 14 (2008) 393-396
20. Hardy J. The Alzheimer family of diseases: many etiologies, one pathogenesis?. Proc Natl Acad Sci U S A 94 (1997) 2095-2097
21. Delacourte A., Sergeant N., Champain D., Wattez A., Maurage C.A., Lebert F., et al. Non-overlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology 59 (2002) 398-407
22. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., and Goedert M. Alpha-synuclein in Lewy bodies. Nature 388 (1997) 839-840
23. Scott W.K., Grubber J.M., Conneally P.M., Small G.W., Hulette C.M., Rosenberg C.K., et al. Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. Am J Hum Genet 66 (2000) 922-932
24. Tedde A., Bagnoli S., Cellini E., Nacmias B., Piacentini S., and Sorbi S. No association between the LRRK2 G2019S mutation and Alzheimer's disease in Italy. Cell Mol Neurobiol 27 (2007) 877-881
25. Lu C.S., Wu-Chou Y.H., van Doeselaar M., Simons E.J., Chang H.C., Breedveld G.J., et al. The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population. Neurogenetics 9 (2008) 271-276