Vascular endothelial growth factor production is regulated by gene polymorphisms

Iranian Journal of Immunology

Volumn 6, Issue 3, 2009, Pages 119-129

  Mohammadi, Mojgan ^a,b   Bazrafshani, Mohammad Reza ^a,c   Day, Philip J ^c   Ollier, William E R ^c  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Faculty of Life Sciences   (United Kingdom)

^c Stopford Building   (United Kingdom)

Author keywords

IL 4; TNF ; VEGF

Indexed keywords

INTERLEUKIN 4; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; LIPOPOLYSACCHARIDE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROMOTER REGION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; ALLELE; BIOSYNTHESIS; DRUG EFFECT; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL;

ADULT; AGED; ALLELES; FEMALE; GENE FREQUENCY; HUMANS; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 74049159591     PISSN: 17351383     EISSN: 1735367X     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246:1306-9.
2. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997; 18:4-25.
3. Pufe T, Peterson W, Tillmann B Mentlein R. Splice variants VEGF 121 and VEGF 165 of the angiogenic peptide vascular endothelial cell growth factor are expressed in the synovial tissue of patients with rheumatoid arthritis. J Rheumatol. 2001; 28:1482-5.
4. Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. curr Top Microbiol Immunol. 1999; 237:1-30.
5. Hunter A, Aitkenhead M, Caldwell C, McCracken G, Wilson D, McClure N. Serum levels of vascular endothelial growth factor in preeclamptic and normotensive pregnancy. Hypertension. 2000; 36:965-9.
6. Endo M, Yanagisawa K, Tsuchida K, Okamoto T, Matsushita T, Higuchi M, et al. Increased levels of vascular endothelial growth factor and advanced glycation end products in aqueous humor of patients with diabetic retinopathy. Horm Metab Res. 2001; 33:317-22.
7. Keogh CL, Yu SP, Wei L. The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. J Pharmacol Exp Ther. 2007; 322:521-8.
8. Sarioǧlu S, Celik A, Erşen A, Uçer I, Saǧlam F, Camsari T, et al. Vascular endothelial growth factor expression and vascular-ity in renal allograft biopsies. Transplant Proc. 2008; 40: 178-80.
9. Abramson LP, Pahl E, Huang L, Stellmach V, Rodgers S, Mavroudis C, et al. Serum vascular endothelial growth factor as a surveillance marker for cellular rejection in paediatric cardiac transplantation. Transplantation. 2002; 73:153-6.
10. Abraham D, Krenn K, Seebacher G, Paulus P, Klepetko W, Aharinejad S. Up-regulated hypoxia-inducible factor-1 DNA binding activity to the vascular endothelial growth factor-A promoter mediates increased vascular permeability in donor lung grafts. Ann Thorac Surg. 2004; 77:1751-5.
11. Reinders ME, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, et al. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest. 2003; 112:1655-65.
12. Ramanathan M, Giladi A, Leibovich SJ. Regulation of vascular endothelial growth factor gene expression in murine macro-phages by nitric oxide and hypoxia. Exp Biol Med. 2003; 228:697-705.
13. Sakuta T, Matsushita K, Yamaguchi N, Oyama T, Motani R, Koga T, et al. Enhanced production of vascular endothelial growth factor by human monocytic cells stimulated with endotoxin through transcription factor SP-1. J Med Microbiol. 2001; 50:233-7.
14. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem. 1991; 266:11947-54.
15. Brogan IJ, Khan N, Isaac K, Hutchinson JA, Pravica V, Hutchinson IV. Novel polymorphisms in the promoter and 5' UTR regions of the human vascular endothelial growth factor gene. Hum Immunol. 1999; 60:1245-9.
16. Churchill AJ, Carter JG, Ramsden C, Turner SJ, Yeung A, Brenchley PE, et al. VEGF polymorphisms are associated with severity of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008; 49:3611-6.
17. Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol. 2002; 13:260-4.
18. Engelhardt B. Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. J Neu-rol Sci. 2008; 15:23-6.
19. Elahi MM, Matata BM, Hakim NS. Quiescent interplay between inducible nitric oxide synthase and tumor necrosis factor-alpha: influence on transplant graft vasculopathy in renal allograft dysfunction. Exp Clin Transplant. 2006; 4:445-50.
20. Dormond O, Contreras AG, Meijer E, Datta D, Flynn E, Pal S, et al. CD40-induced signaling in human endothelial cells re-sults in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo. J Immunol. 2008; 181:8088-95.
21. Girnita DM, Webber SA, Zeevi A. Clinical impact of cytokine and growth factor genetic polymorphisms in thoracic organ transplantation. Clin Lab Med. 2008; 28:423-40.
22. Ardizzone S, Bianchi P.G. Biologic therapy for inflammatory bowel disease. Drugs. 2005; 65(16):2253-86.
23. Davidson C, Verma ND, Robinson CM, Plain KM, Tran GT, Hodgkinson SJ, et al. IL-13 prolongs allograft survival: associa-tion with inhibition of macrophage cytokine activation. Transpl Immunol. 2007; 17:178-86.
24. Rueda B, Perez-Armengol C, Lopez-Lopez S, Garcia-Porrua C, Martin J, Gonzalez-Gay MA. Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura. J Rheumatol. 2006; 33:69-73.
25. Jin Q, Hemminki K, Enquist K, Lenner P, Grzybowska E, Klaes R, et al. Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Clin Cancer res. 2005; 11:3647-53.
26. Koukourakis MI, Papazoglou D, Giatromanolaki A, Bougioukas G, Maltezos E, Sivridis E. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer. 2004; 46:293-8.
27. Howell WM, Bateman AC, Turner SJ, Collins A, Theaker JM. Influence of vascular endothelial growth factor single nucleo-tide polymorphisms on tumour development in cutaneous malignant melanoma. Genes Immun. 2002; 3:229-32.
28. McCarron SL, Edwards S, Evans PR, Gibbs R, Dearnaley DP, Dowe A, et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res. 2002; 62:3369-72.
29. Minguet S, Huber M, Rosenkranz L, Schamel WW, Reth M, Brummer T. Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors. Eur J Immunol. 2005; 35:31-41
30. Azzawi M, Hasleton PS, Turner DM, Yonan N, Deiraniya AK, Sinnott PJ, et al. Tumor necrosis factor-alpha gene polymor-phism and death due to acute cellular rejection in a subgroup of heart transplant recipients. Hum Immunol. 2001; 62:140-2.
31. Bakiri L, Matsuo K, Wisniewska M, Wagner EF, Yaniv M. Promoter specificity and biological activity of tethered AP-1 dimers. Mol Cell Biol. 2002; 22:4952-64.
32. Sankaran D, Asderakis A, Ashraf S, Roberts IS, Short CD, Dyer PA, et al. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation. Kidney Int. 1999; 56:281-8.
33. Jin Q, Hemminki K, Enquist K, Lenner P, Grzybowska E, Klaes R, et al. Vascular Endothelial Growth Factor polymorphisms in relation to breast cancer development and prognosis. Human Cancer Biology. Clin Cancer Res. 2005; 11:3647-53.
34. Liu Q, Li Y, Zhao J, Sun D, Duan Y, Wang N, et al. Association of polymorphisms -1154G/ A and -2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women. Human Reproduction, 2009, 0: 1-7.