Insight into the mechanism of antimicrobial poly(phenylene ethynylene) polyelectrolytes: Interactions with phosphatidylglycerol lipid membranes

Langmuir

Volumn 25, Issue 24, 2009, Pages 13742-13751

  Ding, Liping ^a,b   Chi, Eva Y ^a   Chemburu, Sireesha ^a   Ji, Eunkyung ^c   Schanze, Kirk S ^c   Lopez, Gabriel P ^a   Whitten, David G ^a  

^a University of New Mexico   (United States)

^b SHAANXI NORMAL UNIVERSITY   (China)

^c University of Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIR WATER INTERFACES; ANIONIC LIPIDS; AQUEOUS SOLUTIONS; BACTERIAL CELLS; BIOCIDAL ACTIVITY; CONFORMATIONAL CHANGE; CONJUGATED POLYELECTROLYTES; DIAZABICYCLOOCTANE; ENHANCED FLUORESCENCE; FLUORESCENCE ENHANCEMENT; FLUORESCENCE QUENCHING; FLUORESCENCE RESONANCE ENERGY TRANSFER; GAIN INSIGHT; HIGHER-DEGREE; LIGHT-ACTIVATED ANTIMICROBIAL; LIPID MEMBRANES; LIPID MONOLAYER; LIPID VESICLES; MONOLAYER INSERTIONS; PENDANT GROUPS; PHOSPHATIDYLGLYCEROLS; POLY(PHENYLENE-ETHYNYLENE); SIDE CHAINS; SILICA MICROSPHERES; SPECTRAL CHANGE; STRUCTURAL DIFFERENCES; THREE MODELS; UNILAMELLAR;

CELL MEMBRANES; CYTOLOGY; DYES; ELECTRON ENERGY LEVELS; ENERGY TRANSFER; FLUORESCENCE; LIPID BILAYERS; LIPIDS; MONOLAYERS; ORGANIC POLYMERS; PHASE INTERFACES; POLYELECTROLYTES; SILICA; SPECTROSCOPY; THIOPHENE;

MEMBRANES;

ANTIINFECTIVE AGENT; LIPOSOME; PHOSPHATIDYLGLYCEROL; POLY(PHENYLENE ETHYNYLENE); POLYMER; LIPID BILAYER;

ARTICLE; BACTERIUM; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; LIPID BILAYER; METABOLISM; ULTRASTRUCTURE; BACTERIA; DRUG EFFECTS;

ANTI-BACTERIAL AGENTS; BACTERIA; CELL MEMBRANE; LIPID BILAYERS; MODELS, BIOLOGICAL; PHOSPHATIDYLGLYCEROLS; POLYMERS; UNILAMELLAR LIPOSOMES;

EID: 74049149358     PISSN: 07437463     EISSN: None     Source Type: Journal    
DOI: 10.1021/la901457t     Document Type: Article

References (45)

1. MatsuzaKi, K. Biochim. Biophys. Acta 1999, 1462, 1-10.
2. Zasloff, M. Nature 2002, 415, 389-395.
3. Shai, Y. Biopolymers 2002, 66, 236-248.
4. Thorsteinsson, T.; Msson, M.; Kristinsson, K. G.; Hjlmarsdttir, M. A.; Hilmarsson, H.; Loftsson, T. J. Med. Chem. 2003, 46, 4173-4181.
5. Laopaiboon, L.; Hall, S. J.; Smith, R. N. J. Appl. Microbiol. 2002, 93, 1051-1058.
6. Kenawy, E.-R.; Worley, S. D.; Broughton, R. Biomacromolecules 2007, 8, 1359-1384.
7. Kügler, R.; Bouloussa, O.; Rondelez, F. Microbiology 2005, 151, 1341-1345.
8. Lee, S. B.; Koepsel, R. R.; Morley, S. W.; Matyjaszewski, K.; Sun, Y.; Russell, A. J. Biomacromolecules 2004, 5, 877-882.
9. Lu, L.; Rininsland, F. H.; Wittenburg, S. K.; Achyuthan, K. E.; McBranch, D. W.; Whitten, D. G. Langmuir 2005, 21, 10154-10159.
10. Chemburu, S.; Corbitt, T. S.; Ista, L. K.; Ji, E.; Fulghum, J.; Lopez, G. P.; Ogawa, K.; Schanze, K. S.; Whitten, D. G. Langmuir 2008, 24, 11053-11062.
11. Corbitt, T. S.; Sommer, J. R.; Chemburu, S.; Ogawa, K.; Ista, L. K.; Lopez, G. P.; Whitten, D. G.; Schanze, K. S. Appl. Mater. Interfaces 2009, 1, 48-52.
12. Corbitt, T. S.; Ding, L.; Ji, E.; Ista, L. K.; Ogawa, K.; Lopez, G. P.; Schanze, K. S.; D. G. Whitten. submitted to J. Photochem. Photobio. Sci.
13. Arnt, L.; Rennie, J. R.; Linser, S.; Willumeit, R.; Tew, G. N. J. Phys. Chem. B 2006, 110, 3527-3532.
14. Som, A.; Tew, G. N. J. Phys. Chem. B 2008, 112,3495-3502.
15. Waschinski, C. J.; Barnert, S.; Theobald, A.; Schubert, R.; Kleinschmidt, F.; Hoffmann, A.; Saalwchter, K.; Tiller, J. C. Biomacromolecules 2008, 9, 1764-1771.
16. Hadjicharalambous, C.; Sheynis, T.; Jelinek, R.; Shanahan, M. T.; Ouellette, A. J.; Gizeli, E. Biochemistry 2008, 47, 12626-12634.
17. Kajiya, K.; Hojo, H.; Suzuki, M.; Nanjo, F.; Kumazawa, S.; Nakayama, T. J. Agric. Food Chem. 2004, 52, 1514-1519.
18. Ishitsuka, Y.; Pham, D. S.; Waring, A. J.; Lehrer, R. I.; Lee, K. Y. C. Biochim. Biophys. Acta 2006, 1755, 1450-1460.
19. Zhao, X.; Pinto, M. R.; Hardison, L. M.; Mwaura, J.; Müller, J.; Jiang, H.; Witker, D.; Kleiman, V. D.; Reynolds, J. R.; Schanze,K. S. Macromolecules 2006, 39, 6355-6366.
20. Taranekar, P.; Qiao, Q.; Jiang, H.; Ghiviriga, I.; Schanze, K. S.; Reynold, J. R. J. Am. Chem. Soc. 2007, 129, 8958-8959.
21. Chemburu, S.; Ji, E.; Casana, Y.; Wu, Y.; Buranda, T.; Schanze, K. S.; Lopez, G. P.; Whitten, D. G. J. Phys. Chem. B 2008, 112, 14492-14499.
22. Zeineldin, R.; Piyasena, M. E.; Bergstedt, T. S.; Sklar, L. A.; Whitten, D.; Lopez, G. P. Cytometry Part A 2006, 69A, 335-341.
23. Beigi, F.; Gottschalk, I.; Hägglund, C. L.; Haneskog, L.; Brekkan, E.; Zhang, Y.; Osterberg, T.; Lundahl, P. Int. J. Pharm. 1998, 164, 129-137.
24. Xian, D.-L.; Huang, K.-L.; Hu, W.-G.; Xiao, J.-Y.; Jiao, F.-P. Chin J. Anal. Chem. 2007, 35, 1521-1524.
25. Castillo, J. A.; Pinazo, A.; Carilla, J.; Rosa Infante, M.; Asunción Aisina, M. ; Haro, I. ; Clapés, P. Langmuir 2004, 20, 3379-3387.
26. Tan, C.; Atas, E.; Müller, J. G.; Pinto, M. R.; Kleiman, V. D.; Schanze, K. S. J. Am. Chem. Soc. 2004, 126, 13685-13694.
27. Chen, L.; Xu, S.; McBranch, D.; Whitten, D. J. Am. Chem. Soc. 2000, 122, 9302-9303.
28. Kaur, P.; Yue, H.; Wu, M.; Liu, M.; Treece, J.; Waldeck, D. H. J. Phys. Chem. B 2007, 111, 8589-8596.
29. Liu, Y.; Ogawa, K.; Schanze, K. S. Anal. Chem. 2008, 80, 150-158.
30. Lakowicz, J. R. Principles of Fluorescence Spectroscopy, 2nd ed.; Kluwer Academic/Plenum Publisher: New York, 1999; p 19.
31. Rolinski, O. J.; Birch, D. J. S.; McCartney, L. J.; Pickup, J. C. Appl. Phys. Lett. 2001, 78, 2796-2798.
32. Wistrom, C. A.; Jones, G. M.; Tobias, P. S.; Sklar, L. A. Biophys. J. 1996, 70, 988-997.
33. Pérez-López, S.; Vila-Romeu, N.; Esteller, M. A. A.; Espina, M.; Haro, I.; Mestres, C. J. Phys. Chem. B 2009, 113, 319-327.
34. The results for the present system (cationic CPE and anionic liposomes) are quite different from those reported in a recent study of an anionic CPE with liposomes formed from a zwitterionic phospholipid (ref 35.). In this study, it is indicated that the CPE may associate with the surface of the liposome or become entrapped within the liposome, there is very little crossing of the bilayer by the polymer.
35. Ngo, A. T.; Karam, P.; Fuller, E.; Burger, M.; Cosa, G. J. Am. Chem. Soc. 2008, 130, 457-459.
36. Huang, C.; Mason, J. T. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 308-310.
37. Shai, Y. Biochim. Biophys. Acta 1999, 1462, 55-70.
38. Zeineldin, R.; Piyasena, M. E.; Sklar, L. A.; Whitten, D.; Lopez, G. P. Langmuir 2008, 24, 4125-4131.
39. A reviewer has suggested that the results observed in this study may be explained by an alternative possibility that the polymer-liposome interaction may lead to formation of a cylindrical structure where the polymer is "wrapped" by a coat of phospholipid. We concur with the reviewer that this could explain the observed results and are planning experiments to test this possibility. On the other hand, foramtion of such cylindrical structure would probably lead to film collapse or contraction when the polymer is added to phospholipid monolayer at the air/ water interface and this is not observed in section 3.4.3 where the results from monolayer insertion experiments are described.
40. Maskarinec, S. A.; Hannig, J.; Lee, R. C.; Lee, K. Y. C. Biophys. J. 2002, 82, 1453-1459.
41. Maskarinec, S. A.; Lee, K. Y. C. Langmuir 2003, 19, 1809-1815.
42. Neville, F.; Cahuzac, M.; Konovalov, O.; Ishitsuka, Y.; Lee, K. Y. C.; Kuzmenko, I.; Kale, G. M.; Gidalevitz, D. Biophys. J. 2006, 90, 1275-1287.
43. Ege, C.; Lee, K. Y. C. Biophys. J. 2004, 87, 1732-1740.
44. Ding, L.; Chi, E.; Whitten, D. G. Unpublished work, manuscript in preparation.
45. Sybachin, A. V.; Efimova, A. A.; Litmanovich, E. A.; Menger, F. M.; Yaroslavov, A. A. Langmuir 2007, 23, 10034-10039.