Discovery and SAR of small molecule PAR1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 903-906

  Rilatt, Ian ^a   Mirabel, Etienne ^a   Grand, Bruno Le ^a   Perez, Michel ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Antagonist; PAR1; SAR; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; F 16618; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; C186 65; OLIGOPEPTIDE; PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ARTERIOVENOUS SHUNT; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; EXPERIMENTAL MODEL; HIGH THROUGHPUT SCREENING; NONHUMAN; RAT; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHO CELL LINE; COMPARATIVE STUDY; CRICETULUS; DRUG DEVELOPMENT; DRUG EFFECTS; HAMSTER; HUMAN; LIVER MICROSOME; PHYSIOLOGY; PROCEDURES;

RATTUS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DISCOVERY; HUMANS; MICROSOMES, LIVER; OLIGOPEPTIDES; PROTEASE INHIBITORS; RATS; RECEPTOR, PAR-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74049146813     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.072     Document Type: Article

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