Oral l-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 1, 2010, Pages 62-68

  Toba, Hiroe ^a   Nakamori, Ayako ^a   Tanaka, Yoshimi ^a   Yukiya, Ryosuke ^a   Tatsuoka, Keisuke ^a   Narutaki, Masako ^a   Tokitaka, Masaaki ^b   Hariu, Hitoshi ^b   Kobara, Miyuki ^a   Nakata, Tetsuo ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Shimaya Co Ltd   (Japan)

Author keywords

Histaminergic nerve; L histidine; Nitric oxide; Spontaneously hypertensive rats

Indexed keywords

COMPLEMENTARY DNA; DIPEPTIDYL CARBOXYPEPTIDASE; HISTAMINE; HISTAMINE H2 RECEPTOR ANTAGONIST; HISTAMINE H3 RECEPTOR; HISTIDINE; MESSENGER RNA; NITRIC OXIDE; NORADRENALIN; THIOPERAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; DIALYSATE; DRUG EFFECT; GENE EXPRESSION; HEART RATE; HEMODYNAMIC PARAMETERS; HYPERTENSION; LONG TERM CARE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NONHUMAN; NORADRENALIN URINE LEVEL; NUCLEOTIDE SEQUENCE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; SYSTOLIC BLOOD PRESSURE; WISTAR KYOTO RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; BLOOD PRESSURE; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; HISTIDINE; INJECTIONS, INTRAVENTRICULAR; MALE; MEDULLA OBLONGATA; NITRIC OXIDE; NOREPINEPHRINE; PEPTIDYL-DIPEPTIDASE A; PIPERIDINES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, HISTAMINE H3; VASOMOTOR SYSTEM;

EID: 74049146780     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05227.x     Document Type: Article

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