Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells

Leukemia

Volumn 23, Issue 12, 2009, Pages 2313-2317

  Kim, M ^a,c   Madlambayan, G J ^a   Rahman, M M ^a   Smallwood, S E ^a   Meacham, A M ^a   Hosaka, K ^b   Scott, E W ^b   Cogle, C R ^a   McFadden, G ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER STEM CELL; GENE VECTOR; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; LETTER; LEUKEMIA; MYXOMA VIRUS; PATHOGENICITY; STANDARD; STEM CELL; VIROLOGY;

GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; MYXOMA VIRUS; NEOPLASTIC STEM CELLS; STEM CELLS;

EID: 74049127994     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.219     Document Type: Letter

References (7)

1. Yang H, Eaves C, de Lima M, Lee MS, Champlin RE, McMannis JD et al. A novel triple purge strategy for eliminating chronic myelogenous leukemia (CML) cells from autografts. Bone Marrow Transplant 2006; 37: 575-582. (Pubitemid 43378830)
2. Kirn DH, Thorne SH. Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer. Nat Rev Cancer 2009; 9: 64-71.
3. Stanford MM, McFadden G. Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer. Expert Opin Biol Ther 2007; 7: 1415-1425. (Pubitemid 47475657)
4. McFadden G. Poxvirus tropism. Nat Rev Microbiol 2005; 3: 201-213. (Pubitemid 40298220)
5. Stanford MM, Werden SJ, McFadden G. Myxoma virus in the European rabbit: interactions between the virus and its susceptible host. Vet Res 2007; 38: 299-318. (Pubitemid 46562409)
6. Wang G, Barrett JW, Stanford M, Werden SJ, Johnston JB, Gao X et al. Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. Proc Natl Acad Sci USA 2006; 103: 4640-4645.
7. Wang F, Gao X, Barrett JW, Shao Q, Bartee E, Mohamed MR et al. RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages. PLoS Pathog 2008; 4: e1000099.