Novel fluorescence molecular imaging of chemotherapy-induced intestinal apoptosis

Journal of Biomedical Optics

Volumn 14, Issue 5, 2009, Pages

  Levin, Galit ^a   Shirvan, Anat ^a   Grimberg, Hagit ^a   Reshef, Ayelet ^a   Yogev Falach, Merav ^a   Cohen, Avi ^a   Ziv, Ilan ^a  

^a Aposense Ltd   (Israel)

Author keywords

Apoptosis; ApoSense; Cell death; Chemotherapy; Gastrointestinal damage; Molecular imaging; Optical imaging

Indexed keywords

ADVERSE EFFECT; ANTI-CANCER THERAPIES; APOPTOTIC PROCESS; APOSENSE; DNA FRAGMENTATION; DRUG ADMINISTRATION; EARLY DETECTION; EARLY DIAGNOSIS; EMISSION TOMOGRAPHY; EPITHELIAL CELLS; EX-VIVO; FLUORESCENCE IMAGING; FLUORESCENCE METHOD; FLUORESCENCE MOLECULAR; FLUORESCENT MICROSCOPY; GASTROINTESTINAL DAMAGE; IN-VIVO; INTESTINAL MUCOSA; INTRAVENOUS ADMINISTRATION; MOLECULAR IMAGING; OPTICAL IMAGING; TEMPORAL PROFILE; TIME POINTS;

CELL DEATH; FLUORESCENCE; MAMMALS; TISSUE;

CHEMOTHERAPY;

MUS;

ANTINEOPLASTIC AGENT; CYSTINE; DANSYL CHLORIDE; DI(DANSYL)CYSTINE; DRUG DERIVATIVE; PACLITAXEL;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETIC PROCEDURES; ILEUM; ILEUM TUMOR; MALE; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CYSTINE; DANSYL COMPOUNDS; ILEAL NEOPLASMS; ILEUM; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; MOLECULAR PROBE TECHNIQUES; PACLITAXEL;

EID: 74049121613     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3253303     Document Type: Article

References (32)

1. D. M. Keefe, J. Brealey, G. J. Goland, and A. G. Cummins, "Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans", Gut 47(5), 632-637 (2000).
2. J. A. Daniels, M. K. Gibson, L. Xu, S. Sun, M. I. Canto, E. Heath, J. Wang, M. Brock, and E. Montgomery, "Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect", Am. J. Surg. Pathol. 32(3), 473-477 (2008). (Pubitemid 351398941)
3. K. A. Bell, A. G. Perna, and S. Hsu, "Mucositis as a treatmentlimiting side effect in the use of capecitabine for the treatment of metastatic breast cancer", J. Am. Acad. Dermatol. 45(5), 790-791 (2001). (Pubitemid 33032584)
4. P. G. Rose and M. S. Piver, "Intestinal perforation secondary to paclitaxel", Gynecol. Oncol. 57(2), 270-272 (1995).
5. C. A. Iacobuzio-Donahue, E. L. Lee, S. C. Abraham, J. H. Yardley, and T. T. Wu, "Colchicine toxicity: distinct morphologic findings in gastrointestinal biopsies", Am. J. Surg. Pathol. 25(8), 1067-1073 (2001). (Pubitemid 32685905)
6. C. Eng, "Toxic effects and their management: daily clinical challenges in the treatment of colorectal cancer", Nat. Rev. Clin. Oncol. 6(4), 207-218 (2009).
7. J. M. Bowen, R. J. Gibson, A. Tsykin, A. M. Stringer, R. M. Logan, and D. M. Keefe, "Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy", Int. J. Cancer 121(8), 1847-1856 (2007). (Pubitemid 47417306)
8. D. Sandmeier, P. Chaubert, and H. Bouzourene, "Irinotecan-induced colitis", Int. J. Surg. Pathol. 13(2), 215-218 (2005). (Pubitemid 40617553)
9. R. J. Gibson and D. M. Keefe, "Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies", Support Care Cancer 14(9), 890-900 (2006).
10. A. Reshef, A. Shirvan, E. Shohami, H. Grimberg, G. Levin, A. Cohen, V. Trembovler, and I. Ziv, "Targeting cell death in vivo in experimental traumatic brain injury by a novel molecular probe", J. Neurotrauma 25(6), 569-580 (2008). (Pubitemid 351918433)
11. A. Cohen, I. Ziv, T. Aloya, G. Levin, D. Kidron, H. Grimberg, A. Reshef, and A. Shirvan, "Monitoring of chemotherapy-induced cell death in melanoma tumors by N, N'-Didansyl-L-cystine", Technol. Cancer Res. Treat. 6(3), 221-234 (2007).
12. R. Aloya, A. Shirvan, H. Grimberg, A. Reshef, G. Levin, D. Kidron, A. Cohen, and I. Ziv, "Molecular imaging of cell death in vivo by a novel small molecule probe", Apoptosis 11(12), 2089-2101 (2006). (Pubitemid 44885386)
13. M. Damianovich, I. Ziv, S. N. Heyman, S. Rosen, A. Shina, D. Kidron, T. Aloya, H. Grimberg, G. Levin, A. Reshef, A. Bentolila, A. Cohen, and A. Shirvan, "ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis", Eur. J. Nucl. Med. Mol. Imaging 33(3), 281-291 (2006).
14. A. Reshef, A. Shirvan, H. Grimberg, G. Levin, A. Cohen, A. Mayk, D. Kidron, R. Djaldetti, E. Melamed, and I. Ziv, "Novel molecular imaging of cell death in experimental cerebral stroke", Brain Res. 1144, 156-164 (2007). (Pubitemid 46440847)
15. A. Reshef, A. Shirvan, R. N. Waterhouse, H. Grimberg, G. Levin, A. Cohen, L. G. Ulysse, G. Friedman, G. Antoni, and I. Ziv, "Molecular imaging of neurovascular cell death in experimental cerebral stroke by PET", J. Nucl. Med. 49(9), 1520-1528 (2008).
16. Y. Gavrieli, Y. Sherman, and S. A. Ben-Sasson, "Identification of programmed cell death in situ via specific labeling of nuclear, DNA fragmentation", J. Cell Biol. 119(3), 493-501 (1992).
17. J. H. Garcia, Y. Yoshida, H. Chen, Y. Li, Z. G. Zhang, J. Lian, S. Chen, and M. Chopp, "Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat", Am. J. Pathol. 142(2), 623-35 (1993). (Pubitemid 23057474)
18. C. B. Drachenberg, O. B. Ioffe, and J. C. Papadimitriou, "Progressive increase of apoptosis in prostatic intraepithelial neoplasia and carcinoma: comparison between in situ end-labeling of fragmented DNA and detection by routine hematoxylin-eosin staining", Arch. Pathol. Lab Med. 121(1), 54-58 (1997).
19. N. Barker, M. van de Wetering, and H. Clevers, "The intestinal stem cell", Genes Dev. 22(14), 1856-1864 (2008). (Pubitemid 352008634)
20. T. H. Yen and N. A. Wright, "The gastrointestinal tract stem cell niche", Stem Cell Rev. 2(3), 203-212 (2006). (Pubitemid 47109399)
21. K. M. Laginha, S. Verwoert, G. J. Charrois, and T. M. Allen, "Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors", Clin. Cancer Res. 11(19 Pt 1), 6944-6949 (2005). (Pubitemid 41428752)
22. G. J. Charrois and T. M. Allen, "Multiple injections of pegylated liposomal Doxorubicin: pharmacokinetics and therapeutic activity", J. Pharmacol. Exp. Ther. 306(3), 1058-1067 (2003). (Pubitemid 37025314)
23. T. A. Elbayoumi and V. P. Torchilin, "Tumor-specific antibodymediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice", Int. J. Pharm. 357, 272-279 (2008).
24. V. L. Seewaldt, J. M. Cain, B. A. Goff, H. Tamini, B. Greer, and D. Figge, "A retrospective review of paclitaxel-associated gastrointestinal necrosis in patients with epithelial ovarian cancer", Gynecol. Oncol. 67, 137-140 (1997). (Pubitemid 27500408)
25. N. S. Thakkar and C. S. Potten, "Abrogation of adriamycin toxicity in vivo by cycloheximide", Biochem. Pharmacol. 43(8), 1683-1691 (1992).
26. K. Venkatesh, M. Cohen, C. Evans, P. Delaney, S. Thomas, C. Taylor, A. Abou-Taleb, R. Kiesslich, and M. Thomson, "Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders", World J. Gastroenterol. 15(18), 2214-2219 (2009).
27. R. S. Dacosta, B. C. Wilson, and N. E. Marcon, "New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions", J. Gastroenterol. Hepatol 17(Suppl), S85-104 (2002). (Pubitemid 34539300)
28. H. Inoue, S. E. Kudo, and A. Shiokawa, "Technology insight: laserscanning confocal microscopy and endocytoscopy for cellular observation of the gastrointestinal tract", Nat. Clin. Pract. Gastroenterol. Hepatol. 2(1), 31-37 (2005). (Pubitemid 40812525)
29. P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W Lowe, C. H. Contag, and T. D. Wang, "Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy", Ther. Immunol. 14(4), 454-458 (2008). (Pubitemid 351499384)
30. A. Moglia, A. Menciassi, P. Dario, and A. Cuschieri, "Capsule endoscopy: progress update and challenges ahead", Nat. Rev. Gastroenterol. Hepatol. 6(6), 353-362 (2009).
31. H. Zhang, D. Morgan, G. Cecil, A. Burkholder, N. Ramocki, B. Scull, and P. K. Lund, "Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of adenomas of the, GI tract", Gastrointest. Endosc. 68(3), 520-527 (2008).
32. B. J. Bacskai, G. A. Hickey, J. Skoch, S. T. Kajdasz, Y. Wang, G. F Huang, C. A. Mathis, W. E. Klunk, and B. T. Hyman, "Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice", Proc. Natl. Acad. Sci. U. S. A. 100(21), 12462-12467 (2003). (Pubitemid 37271582)