Effect of tocotrienols on iron-induced renal dysfunction and oxidative stress in rats

Drug and Chemical Toxicology

Volumn 32, Issue 4, 2009, Pages 319-325

  Gupta, Amitt ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

A tocopherol (T); Oxidative stress; Renal injury; Tocotrienol (T3); Tumor necrosis factor alpha (TNF )

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; CREATININE; GLUTATHIONE; NITRILOTRIACETATE IRON; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UREA; ANTINEOPLASTIC AGENT; CARCINOGEN; DRUG DERIVATIVE; FERRIC ION; NITRILOTRIACETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; KIDNEY DYSFUNCTION; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; UREA NITROGEN BLOOD LEVEL; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; KIDNEY; KIDNEY DISEASE; METABOLISM; WISTAR RAT;

RATTUS;

ALPHA-TOCOPHEROL; ANIMALS; ANTICARCINOGENIC AGENTS; BLOOD UREA NITROGEN; CARCINOGENS; CREATININE; FERRIC COMPOUNDS; GLUTATHIONE; KIDNEY; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; NITRILOTRIACETIC ACID; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TOCOTRIENOLS; VITAMIN E;

EID: 74049109712     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540903130633     Document Type: Article

References (45)

1. Ahmad, N. S., Khalid, B. A., Luke, D. A., Ima Nirwana, S., (2005). Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone. Clin Exp Pharmacol Physiol 32:761-770.
2. Awai, M., Narasaki, M., Yamanoi, Y., Seno, S. (1979). Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis. Am J Pathol 95:663-673.
3. Azlina, M. F., Nafeeza, M. I., Khalid, B. A. (2005). A comparison between tocopherol and tocotrienol effects on gastric parameters in rats exposed to stress. Asia Pac J Clin Nutr 14:358-365.
4. Baker, M. S., Gebicki, J. M. (1986). The effect of pH on yields of hydroxyl radicals produced from superoxide by potential biological iron chelators. Arch Biochem Biophys 246:581-588.
5. Bates, G. W., Wernicke, J. (1971). The kinetics and mechanism of iron(3) exchange between chelates and transferrin. IV. The reaction of transferrin with iron(3) nitrilotriacetate. J Biol Chem 246:3679-3685.
6. Baud, L., Ardaillou, R. (1993). Involvement of reactive oxygen species in kidney damage. Br Med Bull 49:621-629.
7. Bomzon, A., Holt, S., Moore, K. (1997). Bile acids, oxidative stress, and renal function in biliary obstruction. Semin Nephrol 17:549-562.
8. Goddard, J. G., Sweeney, G. D. (1983). Ferric nitrilotriacetate: a potent stimulant of in vivo lipid peroxidation in mice. Biochem Pharmacol 32:3879-3882.
9. Gupta, A., Chander, V., Sharma, S., Chopra, K. (2007). Sodium nitroprusside and L-arginine attenuates ferric nitrilotriacetate- induced oxidative renal injury in rats. Toxicology 232:183-191.
10. Gupta, A., Sharma, S., Chopra, K. (2008). Reversal of iron-induced nephrotoxicity in rats by molsidomine, a nitric oxide donor. Food Chem Toxicol 46:537-543.
11. Hamazaki, S., Okada, S., Ebina, Y., Fujioka, M., Midorikawa, O. (1986). Nephrotoxicity of ferric nitrilotriacetate. An electronmicroscopic and metabolic study. Am J Pathol 123:343-350.
12. Jollow, D. J., Mitchell, J. R., Zampaglione, N., Gillette, J. R. (1974). Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11:151-169.
13. Kamat, J. P., Devasagayam, T. P. (1995). Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 195:179-182.
14. Kamat, J. P., Sarma, H. D., Devasagayam, T. P., Nesaretnam, K., Basiron, Y. (1997). Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. Mol Cell Biochem 170:131-137.
15. Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P. W., Ratan, R. R., et al. (2003). Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamateinduced neurodegeneration. J Biol Chem 278:43508-43515.
16. Kono, Y. (1978). Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186:189-195.
17. Kubo, K., Saito, M., Tadokoro, T., Maekawa, A. (1997). Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexanoic acid and vitamin E. Br J Nutr 78:655-669.
18. Liu, M., Okada, S., Kawabata, T. (1991). Radical-promoting "free" iron level in the serum of rats treated with ferric nitrilotriacetate: comparison with other iron-chelate complexes. Acta Med Okayama 45:401-408.
19. Markewitz, B. A., Michael, J. R., Kohan, D. E. (1993). Cytokineinduced expression of a nitric oxide synthatase in rat renal tubule cells. J Clin Invest 91:2138-2143.
20. Matsuura, R. (1983). Uptake of iron and nitrilotriacetate (NTA) in rat liver and the toxic effect of Fe-NTA. Acta Med Okayama 37:393-400.
21. McIntyre, M., Bohr, D. F., Dominiczak, A. F. (1999). Endothelial function in hypertension: the role of superoxide anion. Hypertension 34:539-545.
22. Min, K. S., Morishita, F., Tetsuchikawahara, N., Onosaka, S. (2005). Induction of hepatic and renal metallothionein synthesis by ferric nitrilotriacetate in mice: the role of MT as an antioxidant. Toxicol Appl Pharmacol 204:9-17.
23. Minhajuddin, M., Beg, Z. H., Iqbal, J. (2005). Hypolipidemic and antioxidant properties of tocotrienol-rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem Toxicol 43:747-753.
24. Nesaretnam, K., Stephen, R., Dils, R., Darbre, P. (1998). Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33:461-469.
25. Norazlina, M., Lee, P. L., Lukman, H. I., Nazrun, A. S., Ima-Nirwana, S. (2007). Effects of vitamin E supplementation on bone metabolism in nicotine-treated rats. Singapore Med J 48:195-199.
26. Ohkawa, H., Ohishi, N., Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
27. Okada, S. (1996). Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol Int 46:311-332.
28. Paller, M. S., Hedlund, B. E. (1994). Extracellular iron chelators protect kidney cells from hypoxia/reoxygenation. Free Radic Biol Med 17:597-603.
29. Preece, N. E., Evans, P. F., Howarth, J. A., King, L. J., Parke, D. V. (1988). The induction of autoxidative tissue damage by iron nitrilotriacetate in rats and mice. Toxicol Appl Pharmacol 93:89-100.
30. 2- induced renal epithelial (LLC-PK1) cell injury. Am J Physiol 268:F30-F38.
31. Schaffer, S., Muller, W. E., Eckert, G. P. (2005). Tocotrienols: constitutional effects in aging and disease. J Nutr 135:151-154.
32. Sen, C. K., Khanna, S., Roy, S. (2006). Tocotrienols: vitamin E beyond tocopherols. Life Sci 78:2088-2098.
33. Sen, C. K., Khanna, S., Roy, S., Packer, L. (2000). Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamateinduced PP60(C-SRC) kinase activation and death of HT4 neuronal cells. J Biol Chem 275:13049-13055.
34. Sheridan, A. M., Fitzpatrick, S., Wang, C., Wheeler, D. C., Lieberthal, W. (1996). Lipid peroxidation contributes to hydrogen peroxide-induced cytotoxicity in renal epithelial cells. Kidney Int 49:88-93.
35. Shimoi, K., Shen, B., Toyokuni, S., Mochizuki, R., Furugori, M., Kinae, N. (1997). Protection by alpha G-rutin, a water-soluble antioxidant flavonoid, against renal damage in mice treated with ferric nitrilotriacetate. Jpn J Cancer Res 88:453-460.
36. Suzuki, Y. J., Tsuchiya, M., Packer, L. (1993). Antioxidant activities of dihydrolipoic acid and its structural homologues. Free Radic Res Commun 18:115-122.
37. Tak, P. P., Firestein, G. S. (2001). NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107:7-11.
38. Theriault, A., Chao, J. T., Wang, Q., Gapor, A., Adeli, K. (1999). Tocotrienol: a review of its therapeutic potential. Clin Biochem 32:309-319.
39. Toyokuni, S. (2002). Iron and carcinogenesis: from Fenton reaction to target genes. Redox Rep 7:189-197.
40. Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H., Stadtman, E. R. (1994). Formation of 4-hydroxy-2-nonenal- modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci U S A 91:2616-2620.
41. Uchida, T. (1995). Overview of iron metabolism. Int J Hematol 62:193-202.
42. Umemura, T., Sai, K., Takagi, A., Hasegawa, R., Kurokawa, Y. (1990). Oxidative DNA damage, lipid peroxidation, and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration. Cancer Lett 54:95-100.
43. Wada, S., Satomi, Y., Murakoshi, M., Noguchi, N., Yoshikawa, T., Nishino, H. (2005). Tumor-suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett 229:181-191.
44. Yoshida, Y., Saito, Y., Jones, L. S., Shigeri, Y. (2007). Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants. J Biosci Bioeng 104:439-445.
45. Zhang, D., Okada, S., Kawabata, T., Yasuda, T. (1995). An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum. Biochem. Mol Biol Int 35:635-641.