Confronting morphogen gradients: How important are they for growth?

Science Signaling

Volumn 2, Issue 94, 2009, Pages

  Hamaratoglu, Fisun ^a   Basler, Konrad ^b   Affolter, Markus ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DECAPENTAPLEGIC PROTEIN; MORPHOGEN; PROTEIN; UNCLASSIFIED DRUG; VESTIGIAL PROTEIN; WNT1 PROTEIN; DPP PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; WG PROTEIN, DROSOPHILA;

CELL PROLIFERATION; DROSOPHILA MELANOGASTER; FORELIMB; GENE EXPRESSION; NONHUMAN; ORGAN GROWTH; PRIORITY JOURNAL; SHORT SURVEY; ANIMAL; ARTICLE; MORPHOGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALS; BODY PATTERNING; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; MORPHOGENESIS; WNT1 PROTEIN;

EID: 74049108255     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.294pe67     Document Type: Short Survey

References (24)

1. L. A. Baena-Lopez, X. Franch.-Marro, J. P. Vincent, Wingless promotes growth in a gradient independent manner. Sci. Signal. 2, ra60 (2009).
2. G. Schwank, S. Restrepo, K. Basler, Growth regulation by Dpp: An essential role for Brinker and a non-essential role for graded signaling levels. Development 135, 4003-4013 (2008).
3. M. Affolter, K. Basler, The Decapentaplegic morphogen gradient: From pattern formation to growth regulation. Nat. Rev. Genet. 8, 663-674 (2007).
4. K. M. Cadigan, Regulating morphogen gradients in the Drosophila wing. Semin. Cell Dev. Biol. 13, 83-90 (2002).
5. A. Kicheva, M. Gonzalez-Gaitan, The Decapentaplegic morphogen gradient: A precise definition. Curr. Opin. Cell Biol. 20, 137-143 (2008).
6. T. Tabata, Genetics of morphogen gradients. Nat. Rev. Genet. 2, 620-630 (2001). (Pubitemid 33674785)
7. C. M. Chen, G. Struhl, Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development 126, 5441-5452 (1999). (Pubitemid 30015936)
8. R. Burke, K. Basler, Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269 (1996). (Pubitemid 26235825)
9. C. J. Neumann, S. M. Cohen, Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing. Development 122, 1781-1789 (1996).
10. L. A. Johnston, B. A. Edgar, Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394, 82-84 (1998).
11. D. A. O'Brochta, P. J. Bryant, A zone of non-proliferating cells at a lineage restriction boundary in Drosophila. Nature 313, 138-141 (1985).
12. J. Noordermeer, J. Klingensmith, N. Perrimon, R. Nusse, dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature 367, 80-83 (1994). (Pubitemid 2008657)
13. E. Siegfried, E. L. Wilder, N. Perrimon, Components of wingless signalling in Drosophila. Nature 367, 76-80 (1994). (Pubitemid 2008656)
14. X. Franch-Marro, F.Wendler, J. Griffith, M. M. Maurice, J. P. Vincent, In vivo role of lipid adducts on Wingless. J. Cell Sci. 121, 1587-1592 (2008). (Pubitemid 351911815)
15. M. Zecca, G. Struhl, Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation. Development 134, 3001-3010 (2007). (Pubitemid 47386911)
16. M. Zecca, G. Struhl, Control of Drosophila wing growth by the vestigial quadrant enhancer. Development 134, 3011-3020 (2007). (Pubitemid 47386912)
17. B. Muller, B. Hartmann, G. Pyrowolakis, M. Affolter, K. Basler, Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113, 221-233 (2003). (Pubitemid 36514973)
18. F. A. Martin, A. Perez-Garijo, E. Moreno, G. Morata, The brinker gradient controls wing growth in Drosophila.Development 131, 4921-4930 (2004). (Pubitemid 39485350)
19. G. Pyrowolakis, B. Hartmann, B. Muller, K. Basler, M. Affolter, A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev. Cell 7, 229-240 (2004). (Pubitemid 39145027)
20. S. J. Day, P. A. Lawrence, Measuring dimensions: The regulation of size and shape. Development 127, 2977-2987 (2000).
21. D. Rogulja, K. D. Irvine, Regulation of cell proliferation by a morphogen gradient. Cell 123, 449-461 (2005).
22. E. Piddini, J. P. Vincent, Interpretation of the wingless gradient requires signaling-induced selfinhibition. Cell 136, 296-307 (2009).
23. J. Kim, A. Sebring, J. J. Esch, M. E. Kraus, K. Vorwerk, J. Magee, S. B. Carroll, Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133-138 (1996).
24. We thank V. Dion for critical reading of the manuscript. This work was supported by the Swiss National Science Foundation, the Kantons of Zurich, Basel-Stadt, and Basel-Land, the European Union's Seventh Framework Programme, and SystemsX. ch, the Swiss Initiative in Systems Biology.