Lipase-mediated enantioselective kinetic resolution of racemic acidic drugs in non-standard organic solvents: Direct chiral liquid chromatography monitoring and accurate determination of the enantiomeric excesses

Journal of Chromatography A

Volumn 1217, Issue 7, 2010, Pages 1063-1074

  Ghanem, Ashraf ^a   Aboul Enein, Mohammed Nabil ^b   El Azzouny, Aida ^b   El Behairy, Mohammed F ^b  

^a UNIVERSITY OF TASMANIA   (Australia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Chiralpak IB; Direct monitoring; Enantiomeric excess; Enantioselective HPLC; Kinetic resolution; Lipase; Racemic acidic drugs

Indexed keywords

ACIDIC DRUGS; CHIRALPAK IB; DIRECT MONITORING; ENANTIOMERIC EXCESS; ENANTIOSELECTIVE HPLC; KINETIC RESOLUTION;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ESTERS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIPASES; LIQUIDS; ORGANIC SOLVENTS; STANDARDS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

2 PHENOXYPROPIONIC ACID; CARPROFEN; CELLULOSE TRIS(3,5 DIMETHYLPHENYLCARBAMATE); ETODOLAC; FENOPROFEN; FLURBIPROFEN; IBUPROFEN; INDOPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC SOLVENT; PROPIONIC ACID DERIVATIVE; TIAPROFENIC ACID; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VANILMANDELIC ACID;

ACCURACY; ACIDITY; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME MECHANISM; ESTERIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; RACEMIC MIXTURE; RELIABILITY; SEPARATION TECHNIQUE;

ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERIFICATION; HYDROGEN-ION CONCENTRATION; LIPASE; ORGANIC CHEMICALS; PHARMACEUTICAL PREPARATIONS; PHENYLCARBAMATES; SOLVENTS; STEREOISOMERISM;

EID: 74049101638     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.10.080     Document Type: Article

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