Differential vulnerabilities of urethral afferents in diabetes and discovery of a novel urethra-to-urethra reflex

American Journal of Physiology - Renal Physiology

Volumn 298, Issue 1, 2010, Pages

  Yang, Zhongguang ^a   Dolber, Paul C ^a,b   Fraser, Matthew O ^a  

^a DURHAM VA MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetic acid; Bladder; Capsaicin; Diabetes mellitus; External urethral sphincter; Urethra

Indexed keywords

ACETIC ACID; ALPHA BUNGAROTOXIN; CAPSAICIN; HEXAMETHONIUM; STREPTOZOCIN; AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER SPHINCTER; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROMYOGRAPHY; MICTURITION REFLEX; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PUDENDAL NERVE; RAT; SENSORY NERVE; VOLUNTARY MOVEMENT; ANIMAL; BLADDER; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; FEMALE; INNERVATION; MICTURITION DISORDER; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY NERVE CELL; SPRAGUE DAWLEY RAT; URETHRA;

ACETIC ACID; ANIMALS; CAPSAICIN; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROMYOGRAPHY; FEMALE; NEURONS, AFFERENT; RATS; RATS, SPRAGUE-DAWLEY; SENSORY SYSTEM AGENTS; STREPTOZOCIN; URETHRA; URINARY BLADDER; URINATION DISORDERS;

EID: 74049092816     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00281.2009     Document Type: Article

References (36)

1. Alm P, Zygmunt PK, Iselin C, Larsson B, Uvelius B, Werner S, Andersson KE. Nitric oxide synthase-immunoreactive, adrenergic, cholinergic, and peptidergic nerves of the female rat urinary tract: a comparative study. J Auton Nerv Syst 56: 105-114, 1995.
2. Andersen JT, Bradley WE. Early detection of diabetic visceral neuropathy. An electrophysiologic study of bladder and urethral innervation. Diabetes 25: 1100-1105, 1976.
3. Andersson KE. Bladder activation: afferent mechanisms. Urology 59: 43-50, 2002.
4. Avelino A, Cruz F. TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. Naunyn-Schmiedeberg's Arch Pharmacol 373: 287-299, 2006.
5. Chang HY, Cheng CL, Chen JJ, Peng CW, de Groat WC. Reflexes evoked by electrical stimulation of afferent axons in the pudendal nerve under empty and distended bladder conditions in urethane-anesthetized rats. J Neurosci Methods 150: 80-89, 2006.
6. Conte B, Maggi CA, Meli A. Vesico-inhibitory responses and capsaicin-sensitive afferents in rats. Naunyn Schmiedebergs Arch Pharmacol 339: 178-183, 1989.
7. Dail WG, Evan AP, Gerritsen GC, Dulin WE. Abnormalities in pelvic visceral nerves. A basis for neurogenic bladder in the diabetic Chinese hamster. Investigat Urol 15: 161-166, 1977.
8. de Groat WC, Fraser MO, Yoshiyama M, Smerin S, Tai C, Chancellor MB, Yoshimura N, Roppolo JR. Neural control of the urethra. Scand J Urol Nephrol Suppl 35-43: 106-125, 2001.
9. de Groat WC, Yoshimura N. Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury. Prog Brain Res 152: 59-84, 2006.
10. Faerman I, Glocer L, Celener D, Jadzinsky M, Fox D, Maler M, Alvarez E. Autonomic nervous system and diabetes. Histological and histochemical study of the autonomic nerve fibers of the urinary bladder in diabetic patients. Diabetes 22: 225-237, 1973.
11. Gaballa MA, Peppel K, Lefkowitz RJ, Aguirre M, Dolber PC, Pennock GD, Koch WJ, Goldman S. Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. J Mol Cell Cardiol 30: 1037-1045, 1998.
12. Gustafson KJ, Creasey GH, Grill WM. A catheter based method to activate urethral sensory nerve fibers. J Urol 170: 126-129, 2003.
13. Jung SY, Fraser MO, Ozawa H, Yokoyama O, Yoshiyama M, De Groat WC, Chancellor MB. Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. J Urol 162: 204-212, 1999.
14. Kakizaki H, Fraser MO, de Groat WC. Reflex pathways controlling urethral striated and smooth muscle function in the male rat. Am J Physiol Regul Integr Comp Physiol 272: R1647-R1656, 1997.
15. Kamo I, Cannon TW, Conway DA, Torimoto K, Chancellor MB, de Groat WC, Yoshimura N. The role of bladder-to-urethral reflexes in urinary continence mechanisms in rats. Am J Physiol Renal Physiol 287: F434-F441, 2004.
16. Kobayashi H, Yoshiyama M, Zakoji H, Takeda M, Araki I. Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms. BJU Int. In press.
17. Kontani H, Shiraoya C. Sex difference in urethral response to electrical stimulation of efferent nerves in the pudendal sensory branch of rats. Int J Urol 9: 586-596, 2002.
18. Kullmann FA, Shah MA, Birder LA, de Groat WC. Funtional TRP and ASIC-like channels in cultured urothelial cells from the rat. Am J Physiol Renal Physiol 296: F892-F901, 2009.
19. Leffler A, Mönter B, Koltzenburg M. The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice. Neuroscience 139: 699-709, 2006.
20. Maggi CA, Barbanti G, Santicioli P, Beneforti P, Misuri D, Meli A, Turini D. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans. J Urol 142: 150-154, 1989.
21. McKenna KE, Nadelhaft I. The organization of the pudendal nerve in the male and female rat. J Comp Neurol 248: 532-549, 1986.
22. Mitsui T, Kakizaki H, Kobayashi S, Morita H, Matsumura K, Koyanagi T. Vesicourethral function in diabetic patients: association of abnormal nerve conduction velocity with vesicourethral dysfunction. Neurourol Urodyn 18: 639-645, 1999.
23. Mumtaz FH, Sullivan ME, Thompson CS, Dashwood MR, Naseem KM, Bruckdorfer KR, Mikhailidis DP, Morgan RJ. Alterations in the nitric oxide synthase binding sites and non-adrenergic, non-cholinergic mediated smooth muscle relaxation in the diabetic rabbit bladder outlet: possible relevance to the pathogenesis of diabetic cystopathy. J Urol 162: 558-566, 1999.
24. Pabbidi RM, Yu SQ, Peng S, Khardori R, Pauza ME, Premkumar LS. Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity. Molecular Pain 4: 9-25, 2008.
25. Pacheco P, Camacho MA, Garcia LI, Hernandez ME, Carrillo P, Manzo J. Electrophysiological evidence for the nomenclature of the pudendal nerve and sacral plexus in the male rat. Brain Res 763: 202-208, 1997.
26. Peng CW, Chen JJJ, Cheng CL, Grill W. Role of pudendal afferents in voiding efficiency in the rat. Am J Physiol Regul Integr Comp Physiol 294: R660-R672, 2008.
27. Pinna C, Bolego C, Puglisi L. Effect of substance P and capsaicin on urinary bladder of diabetic rats and the role of the epithelium. Eur J Pharmacol 271: 151-158, 1994.
28. Sasaki K, Chancellor MB, Phelan MW, Yokoyama T, Fraser MO, Seki S, Kubo K, Kumon H, Groat WC, Yoshimura N. Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia. J Urol 168: 1259-1264, 2002.
29. Song L, Schmidt BJ, Shefchyk SJ. Pelvic and pudendal reflexes in the in vitro neonatal rat preparation. Brain Res 675: 165-170, 1995.
30. Steers WD, Mackway-Gerardi AM, Ciambotti J, de Groat WC. Alterations in neural pathways to the urinary bladder of the rat in response to streptozotocin-induced diabetes. J Auton Nerv Syst 47: 83-94, 1994.
31. Thor KB, Muhlhauser MA. Vesicoanal, urethroanal, and urethrovesical reflexes initiated by lower urinary tract irritation in the rat. Am J Physiol Regul Integr Comp Physiol 277: R1002-R1012, 1999.
32. Torimoto K, Fraser MO, Hirao Y, De Groat WC, Chancellor MB, Yoshimura N. Urethral dysfunction in diabetic rats. J Urol 171: 1959-1964, 2004.
33. Torimoto K, Hirao Y, Matsuyoshi H, de Groat WC, Chancellor MB, Yoshimura N. alpha1-Adrenergic mechanism in diabetic urethral dysfunction in rats. J Urol 173: 1027-1032, 2005.
34. Ueda T, Yoshimura N, Yoshida O. Diabetic cystopathy: relationship to autonomic neuropathy detected by sympathetic skin response. J Urol 157: 580-584, 1997.
35. Yang Z, Dolber PC, Fraser MO. Diabetic urethropathy compounds the effects of diabetic cystopathy. J Urol 178: 2213-2219, 2007.
36. Yang Z, Nassar R, Dolber PC, Fraser MO. Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus. Brain Res 1217: 132-138, 2008.