Chondroprotective effect of N-acetylglucosamine and hyaluronate in early stages of osteoarthritis an experimental study in rabbits

Bulletin of the NYU Hospital for Joint Diseases

Volumn 67, Issue 4, 2009, Pages 352-357

  Ozkan, Feyza Unlu ^a   Ozkan, Korhan ^b   Ramadan, Saime ^c   Guven, Zeynep ^d  

^a FATIH SULTAN MEHMET TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b GOZTEPE TRAINING AND RESEARCH HOSPITAL   (Turkey)

^c Department of Pathology   (Turkey)

^d MARMARA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIC ACID; N ACETYLGLUCOSAMINE; SODIUM CHLORIDE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; CARTILAGE; CHONDROPROTECTION; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; EXPERIMENTAL STUDY; FEMUR CONDYLE; GERIATRICS; JOINT FUNCTION; KNEE OSTEOARTHRITIS; MICROSCOPY; NONHUMAN; RABBIT; RANGE OF MOTION; TIBIA;

ACETYLGLUCOSAMINE; ANIMALS; ANTERIOR CRUCIATE LIGAMENT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; INJECTIONS, INTRAMUSCULAR; KNEE JOINT; OSTEOARTHRITIS, KNEE; RABBITS; RANGE OF MOTION, ARTICULAR; TIME FACTORS;

EID: 74049090155     PISSN: 19369719     EISSN: 19369727     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Fenton JI, Chlebek-Brown KA, et al. Glucosamine HCl reduces equine articular cartilage degradation in expiant culture. Osteoarthritis Cartilage. 2000;8:258-65.
2. Amiel D, Toyoguchi T, Kobayashi K, et al. Long-term effect of sodium hyaluronate (Hyalgan) on osteoarthritis progression in a rabbit model. Osteoarthritis Cartilage. 2003;11:636-43.
3. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. J Bone Joint Surg Am. 1971;53(3):523-37.
4. Park YS, Lim SW, Lee IH, et al. Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced anterior cruciate ligament transection in mature rabbits: a randomized controlled trial. Arthritis Res Ther. 2007;9(1):R8.
5. Mihara M, Higo S, Uchiyama Y, et al. Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model. Osteoarthritis Cartilage. 2007 May;15(5):543-9.
6. Marshall KW. Intraarticular hyaluronan therapy. Curr Opinn Rheumatol. 2000;12:468-74.
7. Kobayashi K, Amiel M, Harwood FL, et al. The long-term effects of hyaluronan during development of osteoarthritis following partial meniscectomy in a rabbit model. Osteoarthritis Cartilage. 2000;8:359-65.
8. Takahashi K, Hashimoto S, Kubo T, et al. Hyaluronan supressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model. J Orthop Res. 2001;19:500-3.
9. Guidolin DD, Ronchetti IP, Lini E, et al. Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500-730 kDa sodium hyaluronate (Hyalgan®) and methylprednisolone acetate on primary osteoarthritis of the knee. Osteoarthritis Cartilage. 2001;9:371-81.
10. Shikhman AR, Kuhn K, Alaaeddine N, Lotz M. N-acetylglucosamine prevents IL-1 beta mediated activation of human chondrocytes. J Immunol. 2001;166:5155-60.
11. Oegema TR, Deloria LB, Sandy JD, Hart DA. Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. Arthritis Rheum. 2002;46(9):2495-503.
12. Wang SX, Laverty S, Dumitriu M, et al. The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis Rheum. 2007;56(5):1537-48.
13. Pond MJ, Nuki G. Experimentally induced osteoarthritis in the dog. Ann Rheum Dis. 1973;32:387-8.
14. Yoshioka M, Coutts RD, Amiel D, Hacker SA. Characterization of a model of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage. 1996;4:87-98.
15. Hulth A, Lindverg L, Telhag H. Experimental osteoarthritis in rabbits. Acta Orthop Scand. 1970;41:522-30.
16. Setton LA, Elliot DM, Mow VC. Altered mechanics of cartilage with osteoarthritis: human osteoarthritis and experimental model of joint degeneration. Osteoarthritis Cartilage. 1999;7:2-14.
17. Papaioannou N, Krallis N, Triantafillopoulos I, et al. Optimal timing of research after anterior cruciate ligament resection in rabbits. Contemp Top Lab Anim Sci. 2004;43(6):22-7.
18. Yoshimi T, Kikuchi T, Obara T, et al. Effects of high molecular weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament. Clin Orthop Relat Res. 1994;298:296-304.
19. Jansen EJ, Emans PJ, Van Rhijn LW, et al. Development of partial-thickness articular cartilage injury in a rabbit model. Clin Orthop Relat Res. 2008 Feb;466(2):487-94.
20. Shikhman AR, Amiel D, D'Lima D, et al. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis. 2005;64:89-94.