Rhein lysinate suppresses the growth of tumor cells and increases the anti-tumor activity of taxol in mice

American Journal of Chinese Medicine

Volumn 37, Issue 5, 2009, Pages 923-931

  Lin, Ya Jun ^a   Zhen, Yong Zhan ^b   Shang, Bo Yang ^c   Zhen, Yong Su ^c  

^a BEIJING HOSPITAL   (China)

^b NORTH CHINA COAL MEDICAL COLLEGE   (China)

^c INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

H22 Hepatocellular Carcinoma; In Vivo; Rhein Lysinate; SKOV 3 Cells; Taxol

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROTEIN KINASE B; RHEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HUMAN; IC 50; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER TUMOR; MALE; METABOLISM; MOUSE; PATHOLOGY; PHYTOTHERAPY; RHUBARB; TREATMENT OUTCOME; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; PHYTOTHERAPY; PROTO-ONCOGENE PROTEINS C-AKT; RHEUM; TREATMENT OUTCOME;

EID: 74049089105     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X09007417     Document Type: Article

References (12)

1. Coley, H.M., C.F. Shotton, A. Ajose-Adeogun, H. Modjtahedi and H. Thomas. Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents. Biochem. Pharmacol. 72: 941-948, 2006.
2. Huang, Q., G. Lu, H.M. Shen, M.C. Chung and C.N. Ong. Anti-cancer properties of anthraquinones from rhubarb. Med. Res. Rev. 27: 609-630, 2007.
3. Huang,Y.H. andY.S. Zhen.Rhein induces apoptosis in cancer cells and shows synergywith mitomycin. Acta Pharm. Sin. 36: 334-338, 2001.
4. 2+ on rhein-induced apoptosis in human cervical cancer Ca Ski cells. Anticancer Res. 27: 379-389, 2007.
5. Kuo, P.L.,Y.L. Hsu, L.T. Ng and C.C. Lin. Rhein inhibits the growth and induces the apoptosis of Hep G2 cells. Plant. Med. 70: 12-16, 2004.
6. 2+ dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells. Anticancer Res. 27: 3313-3322, 2007.
7. Lin, Y.J., Y.S. Zhen, X.J. Liu, S.Y. Wu and X.D. Xu. The preparation of RHL and the application in tumor treatment. Patent number 200810089025.8.
8. Qiu, L., W. Di, Q. Jiang, E. Scheffler, S. Derby, J. Yang, N. Kouttab, H. Wanebo, B. Yan and Y. Wan. Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. Int. J. Oncol. 27: 1441-1448, 2005.
9. Qiu, L., C. Zhou, Y. Sun,W. Di, E. Scheffler, S. Healey, H.Wanebo, N. Kouttab, W. Chu and Y. Wan. Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. Oncol. Rep. 16: 907-913, 2006.
10. Shi, P., Z. Huang and G. Chen. Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. Am. J. Chin. Med. 36: 805-813, 2008.
11. Zhang, L.S., Y.K. Lau, W.Y. Xia, G.N. Hortobagyi and M.C. Hung. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing ovarian cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clin. Cancer Res. 5: 343-353, 1999.
12. Zheng, J.H. and D.A. Guo. Modern Research on Rhubarb, 1st ed. Peking University Medical Press, Beijing, China, 2007, pp. 12-13.