Mid-trimester maternal serum markers in predicting adverse pregnancy outcome

Clinical and Experimental Obstetrics and Gynecology

Volumn 36, Issue 4, 2009, Pages 237-240

  Androutsopoulos, G ^a   Gkogkos, P ^a   Papadopoulos, V ^a   Adonakis, G ^a   Tsapanos, V ^a   Vassilakos, P ^a   Panayiotakis, G ^a   Decavalas, G ^a   Evangelinakis, N ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b NONE

Author keywords

Adverse pregnancy outcome; AFP levels; hCG levels; Maternal serum markers

Indexed keywords

ALPHA FETOPROTEIN; BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN;

ADOLESCENT; ADULT; ADVERSE OUTCOME; ARTICLE; CHI SQUARE TEST; CORRELATION COEFFICIENT; DOPPLER ECHOGRAPHY; FEMALE; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL SERUM; PARTHENOGENESIS; PLACENTA FUNCTION; PLACENTA INSUFFICIENCY; PREDICTION; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PROSPECTIVE STUDY; SCREENING TEST; SECOND TRIMESTER PREGNANCY; UTERINE ARTERY;

ADOLESCENT; ADULT; ALPHA-FETOPROTEINS; BIOLOGICAL MARKERS; CHORIONIC GONADOTROPIN; FEMALE; GREECE; HUMANS; MIDDLE AGED; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY TRIMESTER, SECOND; PRENATAL DIAGNOSIS; PROSPECTIVE STUDIES; UTERINE ARTERY; YOUNG ADULT;

EID: 73949146440     PISSN: 03906663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Johnson A.M., Palomaki G.E., Haddow J.E.: "Maternal serum alpha-fetoprotein levels in pregnancies among black and white women with fetal open spina bifida: a United States collaborative study". Am. J. Obstet. Gynecol., 1990, 162, 328.
2. Snijders R.J., Noble P., Sebire N., Souka A., Nicolaides K.H.: "UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group". Lancet, 1998, 352, 343.
3. Morrow R.J., McNay M.B., Whittle M.J.: "Ultrasound detection of neural tube defects in patients with elevated maternal serum alpha-fetoprotein". Obstet. Gynecol., 1991, 78, 1055.
4. Waller D.K., Lustig L.S., Cunningham G.C., Golbus M.S., Hook E.B.: "Second-trimester maternal serum alpha-fetoprotein levels and the risk of subsequent fetal death". N. Engl. J. Med., 1991, 325, 6.
5. Raty R., Koskinen P., Alanen A., Irjala K., Matinlauri I., Ekblad U.: "Prediction of pre-eclampsia with maternal mid-trimester total renin, inhibin A, AFP and free beta-hCG levels". Prenat. Diagn., 1999, 19, 122.
6. Yaron Y., Cherry M., Kramer R.L., O'Brien J.E., Hallak M., Johnson M.P. et al.: "Second-trimester maternal serum marker screening: maternal serum alpha-fetoprotein, beta-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome". Am. J. Obstet. Gynecol., 1999, 181, 968.
7. Walton D.L., Norem C.T., Schoen E.J., Ray G.T., Colby C.J.: "Second-trimester serum chorionic gonadotropin concentrations and complications and outcome of pregnancy". N. Engl. J. Med., 1999, 341, 2033.
8. Gravett C.P., Buckmaster J.G., Watson P.T., Gravett M.G.: "Elevated second trimester maternal serum beta-hCG concentrations and subsequent adverse pregnancy outcome". Am. J. Med. Genet., 1992, 44, 485.
9. Gonen R., Perez R., David M., Dar H., Merksamer R., Sharf M.: "The association between unexplained second-trimester maternal serum hCG elevation and pregnancy complications". Obstet. Gynecol., 1992, 80, 83.
10. nd edition, New York, McGraw Hill, 2005, 811.
11. Seeds J.W.: "Impaired fetal growth: definition and clinical diagnosis". Obstet. Gynecol., 1984, 64, 303.
12. nd edition, New York, McGraw Hill, 2005, 762.
13. Gitlin D., Perricelli A., Gitlin G.M.: "Synthesis of alpha-fetoprotein by liver, yolk sac, and gastrointestinal tract of the human concepts". Cancer Res., 1972, 32, 979.
14. Jones E.A., Clement-Jones M., James O.F., Wilson D.I.: "Differences between human and mouse alpha-fetoprotein expression during early development". J. Anat., 2001, 198 (Pt 5), 555.
15. Mizejewski G.J.: "Levels of alpha-fetoprotein during pregnancy and early infancy in normal and disease states". Obstet. Gynecol. Surv., 2003, 58, 804.
16. Waller D.K., Lustig L.S., Smith A.H., Hook E.B.: "Alpha-fetoprotein: a biomarker for pregnancy outcome". Epidemiology, 1993, 4, 471.
17. Hershkovitz R., de Swiet M., Kingdom J.: "Mid-trimester placentation assessment in high-risk pregnancies using maternal serum screening and uterine artery Doppler". Hypertens. Preg., 2005, 24, 273.
18. Walters B.N., Lao T., Smith V., De Swiet M.: "Alpha-fetoprotein elevation and proteinuric pre-eclampsia". Br. J. Obstet. Gynaecol., 1985, 92, 341.
19. Lenton E.A., Neal L.M., Sulaiman R.: "Plasma concentrations of human chorionic gonadotropin from the time of implantation until the second week of pregnancy". Fertil. Steril., 1982, 37, 773.
20. Alfthan H., Schröder J., Fraser R., Koskimies A., Halila H., Stenman U.H.: "Choriogonadotropin and its beta subunit separated by hydrophobic-interaction chromatography and quantified in serum during pregnancy by time-resolved immunofluorometric assays". Clin. Chem., 1988, 34, 1758.
21. McGregor W.G., Kuhn R.W., Jaffe R.B.: "Biologically active chorionic gonadotropin: synthesis by the human fetus". Science, 1983, 220, 306.
22. Nisula B.C., Blithe D.L., Akar A., Lefort G., Wehmann R.E.: "Metabolic fate of human choriogonadotropin". J. Steroid Biochem., 1989, 33, 733.
23. Fox H.: "Effect of hypoxia on trophoblast in organ culture. A morphologic and autoradiographic study". Am. J. Obstet. Gynecol., 1970, 107, 1058.
24. Morssink L.P., de Wolf B.T., Kornman L.H., Beekhuis J.R., van der Hall TP, Mantingh A.: "The relation between serum markers in the second trimester and placental pathology. A study on extremely small for gestational age fetuses". Br. J. Obstet. Gynaecol., 1996, 103, 779.
25. Heinonen S., Ryynänen M., Kirkinen P., Saarikoski S.: "Velamentous umbilical cord insertion may be suspected from maternal serum alpha-fetoprotein and hCG". Br. J. Obstet. Gynaecol., 1996, 103, 209.
26. Morssink L.P., Sikkema-Raddatz B., Beekhuis J.R., De Wolf B.T., Mantingh A.: "Placental mosaicism is associated with unexplained second-trimester elevation of MShCG levels, but not with elevation of MSAFP levels". Prenat. Diagn., 1996, 16, 845.
27. Shenhav S., Gemer O., Sassoon E., Volodarsky M., Peled R., Segal S.: "Mid-trimester triple test levels in early and late onset severe pre-eclampsia". Prenat. Diagn., 2002, 22, 579.
28. Liu D.F., Dickerman L.H., Redline R.W.: "Pathologic findings in pregnancies with unexplained increases in midtrimester maternal serum human chorionic gonadotropin levels". Am. J. Clin. Pathol., 1999, 111, 209.
29. Luckas M.J., Sandland R., Hawe J., Neilson J.P., McFadyen I.R., Meekins J.W.: "Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels". Placenta, 1998, 19, 143.
30. Lepage N., Chitayat D., Kingdom J., Huang T.: "Association between second-trimester isolated high maternal serum human chorionic gonadotropin levels and obstetric complications in singleton and twin pregnancies". Am. J. Obstet. Gynecol., 2003, 188, 1354.
31. Chitayat D., Farrell S.A., Huang T., Meier C., Wyatt P.R., Summers A.M.: "Double-positive maternal serum screening results for down syndrome and open neural tube defects: an indicator for fetal structural or chromosomal abnormalities and adverse obstetric outcomes". Am. J. Obstet. Gynecol., 2002, 187, 758.
32. Dugoff L., Hobbins J.C., Malone F.D., Vidaver J., Sullivan L., Canick J.A. et al.: "Quad screen as a predictor of adverse pregnancy outcome". Obstet. Gynecol., 2005, 106, 260.
33. Huang T., Owolabi T., Summers A.M., Meier C., Wyatt P.R.: "The identification of risk of spontaneous fetal loss through second-trimester maternal serum screening". Am. J. Obstet. Gynecol., 2005, 193, 395.
34. Gkogkos P., Androutsopoulos G., Vassilakos P., Panayiotakis G., Kourounis G., Decavalas G.: "Mid-trimester maternal serum AFP levels in predicting adverse pregnancy outcome". Clin. Exp. Obstet. Gynecol., 2008, 35, 208.
35. Bewley S., Chard T., Grudzinskas G., Campbell S.: "The relationship of uterine and umbilical Doppler resistance to fetal and placental protein synthesis in the second trimester". Placenta, 1993, 14, 663.