Bronchorelaxant property of 'African potato' (Hypoxis hemerocallidea corm) aqueous extract in vitro

Journal of Smooth Muscle Research

Volumn 45, Issue 5, 2009, Pages 241-248

  Ojewole, John A O ^a   Olayiwola, Gbola ^b   Nyinawumuntu, Agatha ^a  

^a University of KwaZulu Natal Faculty of Health Sciences   (South Africa)

^b OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

African potato (Hypoxis hemerocallidea corm); Aqueous extract; Bronchorelaxant activity; Guineapig; Tracheal smooth muscle

Indexed keywords

CARBACHOL; HISTAMINE; PLANT EXTRACT;

AFRICAN MEDICINE; ANIMAL; ARTICLE; BRONCHUS; CHEMISTRY; DRUG EFFECT; FEMALE; GUINEA PIG; HYPOXIS; IC 50; IN VITRO STUDY; MALE; MUSCLE RELAXATION; PHYSIOLOGY; SMOOTH MUSCLE; TRACHEA;

ANIMALS; BRONCHI; CARBACHOL; FEMALE; GUINEA PIGS; HISTAMINE; HYPOXIS; INHIBITORY CONCENTRATION 50; MALE; MEDICINE, AFRICAN TRADITIONAL; MUSCLE RELAXATION; MUSCLE, SMOOTH; PLANT EXTRACTS; TRACHEA;

EID: 73949127841     PISSN: 09168737     EISSN: None     Source Type: Journal    
DOI: 10.1540/jsmr.45.241     Document Type: Article

References (24)

1. Albrecht, C.F. (1995). Hypoxoside: A putative prodrug for the treatment of malignancies, HIV infections, and inflammatory conditions. S. Afr. Med. J. 85: 302-307.
2. Albrecht, C.F. (1996). Hypoxoside: A putative, non-toxic prodrug for the possible treatment of certain malignancies, HIV infections, and inflammatory conditions. In: Chemistry, Biological and Pharmacological Properties of African Medicinal Plants. Proceedings of the First International IOCD Symposium; Victoria Falls, Zimbabwe, ed. by K. Hostettmann, F. Chinyanganya, M. Maillard and J.L. Wolfender, University of Zimbabwe Press, Harare, pp. 303-307.
3. Drewes, S.E., Hall, A.J., Learmonth, R.A. and Upfold, U.J. (1984). Isolation of hypoxoside from Hypoxis rooperi and synthesis of [E]-1, 5-bis [3', 4'-dimethoxyphenyl 1] pent-4-en-1-yne. Phytochemist. 23: 1313-1316.
4. Foster, R.W. (1960). The paired tracheal chain preparation. J. Pharm. Pharmacol. 12: 189-191.
5. Hutchings, A. (1989). A survey and analysis of traditional medicinal plants as used by the Zulu, Xhosa and Sotho. Bothalia. 19: 111-123.
6. Hutchings, A., Scott, A.H., Lewis, G. and Cunningham, A.B. (1996). Zulu Medicinal Plants-An Inventory, University of Natal Press, Pietermaritzburg, pp. 55-56.
7. Johnson, Q., Syce, J., Nell, H., Rudeen, K. and Folk, W.R. (2007). A randomized, double-blind, placebo-controlled trial of Lessertia frutescens in healthy adults. PLos Clin. Trials 2: e16 (1-7).
8. Mahomed, I.M. and Ojewole, J.A.O. (2003). Hypoglycaemic effect of Hypoxis hemerocallidea corm ('African Potato') aqueous extract in rats. Methods Find. Exp. Clin. Pharmacol. 25: 617-623.
9. Mongomery, D. (1991). Diseñno y Análisis de Experimentos. ed. by Grupo Editorial Ibero-americana. SA. de CV, México, pp. 45-81.
10. Musabayane, C.T., Mahlalela, N., Shode, F.O. and Ojewole, J.A.O. (2005a). Effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocininduced diabetic rats. J. Ethnopharmacol. 97: 485-490.
11. Musabayane, C.T., Xozwa, K. and Ojewole, J.A.O. (2005b). Effects of Hypoxis hemerocallidea (Fisch. & C.A. Mey.) [Hypoxidaceae] corm ('African potato') aqueous extract on renal electrolyte and fluid handling in the rat. Ren. Fail. 27: 1-8.
12. Ojewole, J.A.O. (1977). Studies on the pharmacology of some antimalarial drugs. PhD Thesis, University of Strathclyde, Glasgow, Scotland, UK.
13. Ojewole, J.A.O. (2001). Traditional medicine and African indigenous plant remedies: evaluation of crude plant drugs used as antidiabetic remedies in zulu folk medicine. Curare 24: 143-160.
14. Ojewole, J.A.O. (2002). Anti-inflammatory properties of Hypoxis hemerocallidea corm (African potato) extracts in rats. Methods Find. Exp. Clin. Pharmacol. 24: 685-687.
15. Ojewole, J.A.O. (2003). Evaluation of the anti-inflammatory properties of Sclerocarya birrea (A. Rich.) Hochst. (family: Anacardiaceae) stem-bark extracts in rats. J. Ethnopharmacol. 85: 217-220.
16. Ojewole, J.A.O. (2004). Evaluation of the analgesic, anti-inflammatory and antidiabetic properties of Sclerocarya birrea (A. Rich.) Hochst. stem-bark aqueous extract in mice and rats. Phytother. Res. 18: 601-608.
17. Ojewole, J.A.O. (2005). Antinociceptive, anti-inflammatory and antidiabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract. J. Ethnopharmacol. 99: 13-19.
18. Ojewole, J.A.O. (2006). Antinociceptive, anti-inflammatory and antidiabetic properties of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ['African Potato'] aqueous extract in mice and rats. J. Ethnopharmacol. 103: 126-134.
19. Ojewole, J.A.O. (2008). Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ['African potato'] aqueous extract in mice. Phytother. Res. 22: 91-96.
20. Owira, P.M. and Ojewole, J.A.O. (2009). 'African Potato' (Hypoxis hemerocallidea corm): a plant-medicine for modern and 21st century diseases of mankind?-a review. Phytother. Res. 23: 147-152.
21. Pujol, J. (1990). Naturafrica-The Herbalist Handbook, Jean Pujol Natural Healers' Foundation, Durban, South Africa.
22. Steenkamp, V., Gouws, M.C., Gulumian, M., Elgorashi, E.E. and van Staden, J. (2006). Studies on antibacterial, anti-inflammatory and antioxidant activities of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J. Ethnopharmacol. 103: 71-75.
23. Van Wyk, B-E., Van Oudtshoorn, B. and Gericke, N. (2002). Medicinal Plants of South Africa, 2nd ed., Briza Publications, Pretoria, South Africa, pp. 156-157.
24. Watt, J.M. and Breyer-Brandwijk, M.G. (1962). Medicinal and Poisonous Plants of Southern and Eastern Africa, 2nd ed., E. & S. Livingstone Ltd., Edinburgh and London, pp. 39-41.