Two new cytotoxic triterpene glycosides from the sea cucumber Holothuria scabra

Planta Medica

Volumn 75, Issue 15, 2009, Pages 1608-1612

  Han, Hua ^a,b   Yi, Yanghua ^a   Xu, Qiangzhi ^a   La, Mingping ^a   Zhang, Hongwei ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Cytotoxity; Holothuria scabra; Scabraside A; Scabraside B; Sea cucumber; Triterpene glycoside

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; GLYCOSIDE; SCABRASIDE A; SCABRASIDE B; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOLOTHURIA SCABRA; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INFRARED SPECTROSCOPY; LEUKEMIA; LIVER CELL CARCINOMA; LUNG CANCER; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SEA CUCUMBER;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GLYCOSIDES; HOLOTHURIA; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; TRITERPENES;

HOLOTHURIA SCABRA; HOLOTHURIIDAE; HOLOTHUROIDEA;

EID: 73949122280     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185865     Document Type: Article

References (11)

1. Stonik V A., Elyakov G B. Secondary metabolites from echinoderms as chemotaxonomic markers. Scheuer PJ Bioorganic marine chemistry. Berlin Springer 1988 43-86
2. Maier M S., Roccatagliata A J., Kuriss A, Cludil H, Seldes A M., Pujol C A., Damonte E B. Two new cytotoxic and virucidal trisulfated triterpene glycosides from the Antarctic sea cucumber Staurocucumis liouvillei. J Nat Prod 2001 64 732-736
3. Chludil H D., Muniain C C., Seldes A M., Maier M S. Cytotoxic and antifungal triterpene glycosides from the Patagonian sea cucumber Hemoiedema spectabilis. J Nat Prod 2002 65 860-865
4. Liao Y L. Chinese fauna Echinodermata holothuroidea. Beijing Science Press 1997 101-103
5. Zou Z R., Yi Y H., Wu H M., Wu J H., Liaw C C., Lee K H. Intercedensides AC, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. J Nat Prod 2003 66 1055-1060
6. Tang H F., Yi Y H., Li L, Sun P, Zhang S Q., Zhao Y P. Three new asterosaponins from the starfish Culcita novaeguineae and their bioactivity. Planta Med 2005 71 458-463
7. Skehan P, Storeng R, Scudiero D, Monks A, Mcmahon J, Vistica D, Warren J T., Bokesch H, Kenney S, Boyd M R. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990 82 1107-1112
8. DeLean A D., Munson P J., Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 1978 235 E97-E102
9. Silchenko A S., Stonik V A., Avilov S A., Kalinin V I., Kalinovsky A I., Zaharenko A M., Smirnov A V., Mollo E, Cimino G. Holothurins B(2), B(3), and B(4), new triterpene glycosides from mediterranean sea cucumbers of the genus holothuria. J Nat Prod 2005 68 564-567
10. Breitmaier E, Voelter W. Carbon-13 NMR spectroscopy, 3rdedition. Weinheim VCH 1987
11. Han H, Yi Y H., Li L, Wang X H., Liu B S., Sun P, Pan M X. A new triterpene glycoside from the sea cucumber Holothuria leucospilota. Chin Chem Lett 2007 18 161-164