Novel diphenyl esters of peptidyl α-aminoalkylphosphonates as inhibitors of chymotrypsin and subtilisin

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 6, 2009, Pages 1229-1236

  Pietrusewicz, Ewa ^a   Sieńczyk, Marcin ^a   Oleksyszyn, Józef ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Chymotrypsin inhibitor; Diphenyl aminoalkylphosphonates; Peptidyl aminoalkylphosphonates; Serine protease inhibitors; Subtilisin inhibitor

Indexed keywords

2 METHYLPHENYL ESTER; 2,3 DIMETHYLPHENYL ESTER; 3 CHLOROPHENYL ESTER; 3,4,5 TRIMETHYLPHENYL ESTER; 4 CARBOXYMETHYLPHENYL ESTER; 4 CHLOROPHENYL ESTER; 4 ETHYLPHENYL ESTER; 4 ISOPROPYLPHENYL ESTER; 4 MERCAPTOMETHYLPHENYL ESTER; 4 METHOXYPHENYL ESTER; 4 METHYLSULFONYLPHENYL ESTER; 4 TERT BUTYLPHENYL ESTER; 4,5 DIMETHYLPHENYL ESTER; CHYMOTRYPSIN; ESTER DERIVATIVE; PEPTIDYL ALPHA AMINOALKYLPHOSPHONIC ACID DIPHENYL ESTER; PHENYLALANINE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; SUBTILISIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RING OPENING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALKYLATION; AMINES; BIPHENYL COMPOUNDS; CHYMOTRYPSIN; ESTERS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDES; PHOSPHONIC ACIDS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBTILISINS;

EID: 73949121869     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756360902781512     Document Type: Article

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