A novel combinatorial approach to high-density peptide arrays

Methods in Molecular Biology

Volumn 570, Issue , 2009, Pages 309-316

  Beyer, Mario ^a   Block, Ines ^a   König, Kai ^a   Nesterov, Alexander ^a   Fernandez, Simon ^a   Felgenhauer, Thomas ^a   Schirwitz, Christopher ^a   Leibe, Klaus ^a   Bischoff, Ralf F ^a   Breitling, Frank ^a   Stadler, Volker ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

amino acid microparticles; atom transfer radical polymerization (ATRP); combinatorial peptide libraries; peptide array; peptide chips; Solid phase peptide synthesis

Indexed keywords

MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; PEPTIDE LIBRARY; PLASMA PROTEIN; POLYETHYLENE GLYCOL METHACRYLATE; STABLE PLASMA PROTEIN SOLUTION;

ANIMAL; BIOLOGICAL MODEL; COMBINATORIAL CHEMISTRY; HIGH THROUGHPUT SCREENING; HUMAN; INSTRUMENTATION; METHODOLOGY; PROTEIN MICROARRAY; REVIEW; STAINING; SURFACE PROPERTY;

ANIMALS; BLOOD PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METHACRYLATES; MODELS, BIOLOGICAL; PEPTIDE LIBRARY; POLYETHYLENE GLYCOLS; PROTEIN ARRAY ANALYSIS; STAINING AND LABELING; SURFACE PROPERTIES;

EID: 73949116979     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-394-7_16     Document Type: Article

References (6)

1. For a short historical summary: Kimmerlin, T., Seebach, D. (2005). "100 years of peptide synthesis": Ligation methods for peptide and protein synthesis with applications to βpeptide assemblies. J. Pept. Res. 65(2), 229-260.
2. Frank, R. (1992). Spot-synthesis: An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron 48, 9217-9232.
3. Review: Lam, K. S., Lebl, M., Krchnak, V. (1997). The "One-Bead-One-Compound" Combinatorial Library Method. Chem. Rev. 97, 411-448.
4. Beyer, M., Nesterov, A., Block, I., König, K., Felgenhauer, T., Fernandez, S., Leibe, K., Torralba, G., Hausmann, M., Trunk, U., Lindenstruth, V., Bischoff, F. R., Stadler, V., Breitling, F. (2007). Combinatorial Synthesis of Peptide Arrays onto a Microchip. Science 318, 1888. , : These authors contributed equally to this work.
5. Stadler, V., Beyer, M., König, K., Nesterov, A., Torralba, G., Lindenstruth, V., Hausmann, M., Bischoff, F. R., Breitling, F. (2007). Multifunctional CMOS Microchip Coatings for Protein and Peptide Arrays. J. Proteome Res. 6, 3197-3202.
6. Beyer, M., Felgenhauer, T., Bischoff, R. F., Breitling, F., Stadler, V. (2006). A novel glass slide-based peptide array support with high functionality resisting non-specific protein adsorption. Biomaterials 27(18), 3505-3514.