Semisynthetic latrunculin B analogs: Studies of actin docking support a proposed mechanism for latrunculin bioactivity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 21, 2009, Pages 7517-7522

  Kudrimoti, Sucheta ^a   Ahmed, Safwat A ^c   Daga, Pankaj R ^a   Wahba, Amir E ^a   Khalifa, Sherief I ^d   Doerksen, Robert J ^a,b   Hamann, Mark T ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c Suez Canal University   (Egypt)

^d MISR INTERNATIONAL UNIVERSITY   (Egypt)

Author keywords

G Actin; Latrunclins

Indexed keywords

15 METHOXY N DECYL LAT B; 15 METHOXY N HEXYL LAT B; 15 METHOXY N METHYL LAT B; 15 METHOXY N NONYL LAT B; 15 METHOXY N OCTYL LATB; 15 METHOXY N PENTYL LAT B; 15 METHOXYLAT B; G ACTIN; LATRUNCULIN A; LATRUNCULIN B; N DECYL LAT B; UNCLASSIFIED DRUG; ACTIN; ANTIFUNGAL AGENT; ANTIPROTOZOAL AGENT; FUSED HETEROCYCLIC RINGS; THIAZOLIDINE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG SYNTHESIS; MOLECULAR DOCKING; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; METABOLISM; SPONGE (PORIFERA); SYNTHESIS;

NEGOMBATA MAGNIFICA; RUMEX;

ACTINS; ANIMALS; ANTIFUNGAL AGENTS; ANTIPROTOZOAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; PORIFERA; THIAZOLIDINES;

EID: 73949108748     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.012     Document Type: Article

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