Mechanisms involved in the relaxant action of testosterone in the renal artery from male normoglycemic and diabetic rabbits

Pharmacological Research

Volumn 61, Issue 2, 2010, Pages 149-156

  Marrachelli, Vannina G ^a   Miranda, Francisco J ^a   Centeno, José M ^a   Burguete, María C ^a   Castelló Ruiz, María ^a,b   Jover Mengual, Teresa ^a   Pérez, Antonio M ^a   Salom, Juan B ^a,b   Torregrosa, Germán ^a,b   Alborch, Enrique ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Calcium; Cyclooxygenases; Diabetes; Endothelium; Nitric oxide synthases; Renal artery; Testosterone

Indexed keywords

CALCIUM CHLORIDE; CALCIUM ION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE; PROSTACYCLIN; TESTOSTERONE; TETRYLAMMONIUM; THROMBOXANE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DIABETES MELLITUS; DRUG MECHANISM; EXTRACELLULAR SPACE; GLUCOSE BLOOD LEVEL; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RABBIT; RAT; RENAL ARTERY; VASODILATATION;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CALCIUM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; IMMUNOENZYME TECHNIQUES; INDOMETHACIN; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; NITROARGININE; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; PROSTAGLANDINS I; RABBITS; RENAL ARTERY; SIGNAL TRANSDUCTION; TESTOSTERONE; TETRAETHYLAMMONIUM; THROMBOXANE A2; VASODILATION;

EID: 73949103491     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.09.002     Document Type: Article

References (29)

1. Marshall S.M., and Flyvbjerg A. Prevention and early detection of vascular complications of diabetes. BMJ 333 (2006) 475-480
2. Harjutsalo V., Katoh S., Sarti C., Tajima N., and Tuomilehto J. Population-based assessment of familial clustering of diabetic nephropathy in type 1 diabetes. Diabetes 53 (2004) 2449-2454
3. Jones C.A., Krolewski A.S., Rogus J., Xue J.L., Collins A., and Warram J.H. Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause?. Kidney Int 67 (2005) 1684-1691
4. Maggio M., and Basaria S. Welcoming low testosterone as a cardiovascular risk factor. Int J Impot Res 21 (2009) 261-264
5. Corona G., Mannucci E., Forti G., and Maggi M. Following the common association between testosterone deficiency and diabetes mellitus, can testosterone be regarded as a new therapy for diabetes?. Int J Androl June 15 (2009) [Epub ahead of print, PubMed PMID: 19538523]
6. 2 receptor activation in female sex. J Cardiovasc Pharmacol 48 (2006) 191-198
7. Carrero J.J., Qureshi A.R., Parini P., Arver S., Lindholm B., Bárány P., et al. Low serum testosterone increases mortality risk among male dialysis patients. J Am Soc Nephrol 20 (2009) 613-620
8. Xu Q., Wells C.C., Garman J.H., Asico L., Escano C.S., and Maric C. Imbalance in sex hormone levels exacerbates diabetic renal disease. Hypertension 51 (2008) 1218-1224
9. Bellinghieri G., Santoro D., Mallamace A., and Savica V. Sexual dysfunction in chronic renal failure. J Nephrol 21 Suppl. 13 (2008) S113-S117
10. Kapoor D., Malkin C.J., Channer K.S., and Jones T.H. Androgens, insulin resistance and vascular disease in men. Clin Endocrinol (Oxf) 63 (2005) 239-250
11. Liu P.Y., Death A.K., and Handelsman D.J. Androgens and cardiovascular disease. Endocr Rev 24 (2003) 313-340
12. Kienitz T., and Quinkler M. Testosterone and blood pressure regulation. Kidney Blood Press Res 31 (2008) 71-79
13. Yanes L.L., Sartori-Valinotti J.C., Iliescu R., Romero D.G., Racusen L.C., Zhang H., et al. Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats. Am J Physiol Renal Physiol 296 (2009) F771-F779
14. Chou T.M., Sudhir K., Hutchison S.J., Ko E., Amidon T.M., Collins P., et al. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 94 (1996) 2614-2619
15. Molinari C., Battaglia A., Grossini E., Mary D.A., Vassanelli C., and Vacca G. The effect of testosterone on regional blood flow in prepubertal anaesthetized pigs. J Physiol 543 (2002) 365-372
16. Jones R.D., Pugh P.J., Jones T.H., and Channer K.S. The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action?. Br J Pharmacol 138 (2003) 733-744
17. Haller H. Endothelial function. General considerations. Drugs 53 Suppl. 1 (1997) 1-10
18. De Vriese A.S., Verbeuren T.J., Van de Voorde J., Lameire N.H., and Vanhoutte P.M. Endothelial dysfunction in diabetes. Br J Pharmacol 130 (2000) 963-974
19. Alabadí J.A., Miranda F.J., Lloréns S., Ruiz de Apodaca R.F., Centeno J.M., and Alborch E. Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries. Eur J Pharmacol 415 (2001) 225-232
20. Miranda F.J., Alabadí J.A., Lloréns S., Ruiz de Apodaca R.F., Centeno J.M., and Alborch E. Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine. Eur J Pharmacol 439 (2002) 121-127
21. Marrachelli V.G., Miranda F.J., Alabadí J.A., Lloréns S., and Alborch E. Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes. Eur J Pharmacol 534 (2006) 178-186
22. Marrachelli V.G., Miranda F.J., Centeno J.M., Salom J.B., Torregrosa G., Jover-Mengual T., et al. Role of NO-synthases and cyclooxygenases in the hyperreactivity of male rabbit carotid artery to testosterone under experimental diabetes. Pharmacol Res June 30 (2009) [Epub ahead of print, PubMed PMID: 19573602]
23. Miner M.M., and Seftel A.D. Centrally acting mechanisms for the treatment of male sexual dysfunction. Urol Clin North Am 34 (2007) 483-496
24. Centol I., López-Blanco F., Deniz A., Benítez L., Marrero-Arencibia I., Fanjul L., et al. Serum androgen levels after streptozotocin administration in the male rat. Rev Esp Fisiol 44 (1988) 31-34
25. Jones R.D., Hugh Jones T., and Channer K.S. The influence of testosterone upon vascular reactivity. Eur J Endocrinol 151 (2004) 29-37
26. Seyrek M., Yildiz O., Ulusoy H.B., and Yildirim V. Testosterone relaxes isolated human radial artery by potassium channel opening action. J Pharmacol Sci 103 (2007) 309-316
27. Malkin C.J., Jones R.D., Jones T.H., and Channer K.S. Effect of testosterone on ex vivo vascular reactivity in man. Clin Sci (Lond) 111 (2006) 265-274
28. Unemoto T., Matsushita M., Tamura K., Tanaka Y., Koike K., and Kogo H. Role of BK channels in testosterone-induced relaxation of the aorta in spontaneously hypertensive rats. Biol Pharm Bull 30 (2007) 1477-1480
29. 2+ channels. Biochem Biophys Res Commun 318 (2004) 503-506