Single-center management of 136 patients with cancer of unknown primary site (CUP Syndrome) over a period of 10 years

Onkologie

Volumn 32, Issue 12, 2009, Pages 741-746

  Thöm, Ina ^a   Rogers, Claudia ^a   Andritzky, Birte ^a   Witzel, Isabell ^a   Schuch, Gunter ^a   Hossfeld, Dieter Kurt ^b   Bokemeyer, Carsten ^a   Laack, Eckart ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b Onkologische Schwerpunktpraxis Lerchenfeld   (Germany)

Author keywords

Cancer of unknown primary; CUP syndrome; Retrospective analysis

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER OF UNKNOWN PRIMARY SITE; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; DISEASE SEVERITY; FEMALE; HEMATOLOGY; HISTOPATHOLOGY; HUMAN; KARNOFSKY PERFORMANCE STATUS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROGNOSIS; RETROSPECTIVE STUDY; SEX DIFFERENCE; TREATMENT RESPONSE;

EID: 73949087971     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000252797     Document Type: Article

References (21)

1. Le Chevalier T, Cvitkovic E, Caille P, Harvey J, Contesso G, Spielmann M, Rouesse J: Early metastatic cancer of unknown primary origin at presentation. A clinical study of 302 consecutive autopsied patients. Arch Intern Med 1988;148:2035-2039.
2. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ: Cancer statistics, 2003. CA Cancer J Clin 2003;53:5-26.
3. Hess KR, Abbruzzese MC, Lenzi R, Raber MN, Abbruzzese JL: Classification and regression tree analysis of 1000 consecutive patients with unknown primary carcinoma. Clin Cancer Res 1999;5:3403-3410.
4. Van De Wouw AJ, Janssen-Heijnen ML, Coebergh JW, Hillen HF: Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984- 1992. Eur J Cancer 2002;38:409-413.
5. Varadhachary GR, Abbruzzese JL, Lenzi R: Diagnostic strategies for unknown primary cancer. Cancer 2004;100:1776-1785.
6. Bugat R, Bataillard A, Lesimple T, Voigt JJ, Culine S, Lortholary A, Merrouche Y, Ganem G, Kaminsky MC, Negrier S, Perol M, Laforet C, Bedossa P, Bertrand G, Coindre JM, Fizazi K: Summary of the standards, options and recommendations for the management of patients with carcinoma of unknown primary site (2002). Br J Cancer 2003; 89(suppl 1):S59-S66. (Pubitemid 37076150)
7. Abbruzzese JL, Abbruzzese MC, Lenzi R, Hess KR, Raber MN: Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J Clin Oncol 1995;13:2094-2103.
8. Briasoulis E, Pavlidis N, Felip E: Cancers of unknown primary site: ESMO clinical recommendation for diagnosis, treatment and follow-up. Ann Oncol 2008;19(suppl 2):ii106-ii107.
9. Agulnik M: Occult primary; In NCCN Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network, 2008.
10. Dowell JE: Cancer from an unknown primary site. Am J Med Sci 2003;326:35-46.
11. Ayoub JP, Hess KR, Abbruzzese MC, Lenzi R, Raber MN, Abbruzzese JL: Unknown primary tumors metastatic to liver. J Clin Oncol 1998;16:2105-2112.
12. Gaber AO, Rice P, Eaton C, Pietrafitta JJ, Spatz E, Deckers PJ: Metastatic malignant disease of unknown origin. Am J Surg 1983;145:493-497.
13. Kirsten F, Chi CH, Leary JA, Ng AB, Hedley DW, Tattersall MH: Metastatic adeno or undifferentiated carcinoma from an unknown primary site - natural history and guidelines for identification of treatable subsets. Q J Med 1987;62:143-161.
14. Garrow GC, Greco FA, Hainsworth JD: Poorly differentiated neuroendocrine carcinoma of unknown primary tumor site. Semin Oncol 1993;20:287-291.
15. Hainsworth JD, Johnson DH, Greco FA: Poorly differentiated neuroendocrine carcinoma of unknown primary site. A newly recognized clinicopathologic entity. Ann Intern Med 1988;109:364-371.
16. Didolkar MS, Fanous N, Elias EG, Moore RH: Metastatic carcinomas from occult primary tumors. A study of 254 patients. Ann Surg 1977;186:625-630.
17. Pasterz R, Savaraj N, Burgess M: Prognostic factors in metastatic carcinoma of unknown primary. J Clin Oncol 1986;4:1652-1657.
18. Greco FA, Hainsworth JD: Poorly differentiated carcinoma or adenocarcinoma of unknown primary site: Long-term results with cisplatin-based chemotherapy. Semin Oncol 1994;21:77-82.
19. Hainsworth JD, Erland JB, Kalman LA, Schreeder MT, Greco FA: Carcinoma of unknown primary site: Treatment with 1-hour paclitaxel, carboplatin, and extended-schedule etoposide. J Clin Oncol 1997;15:2385-2393.
20. Hübner G, Tamme C, Wildfang I, Schöber C, Schmoll HJ: Management of patients with carcinoma of unknown primary (CUP-syndrome). J Cancer Res Clin Oncol 1990;116(suppl I):abstr.190.
21. Van Der Gaast A, Verweij J, Planting AS, Hop WC, Stoter G: Simple prognostic model to predict survival in patients with undifferentiated carcinoma of unknown primary site. J Clin Oncol 1995;13:1720-1725.