Biological extraction of realgar by Acidithiobacillus ferrooxidans and its in vitro and in vivo antitumor activities

Pharmaceutical Biology

Volumn 48, Issue 1, 2010, Pages 40-47

  Zhang, Xu ^a   Xie, Qin Jian ^a   Wang, Xin ^a   Wang, Bo ^b   Li, Hong Yu ^a  

^a LANZHOU UNIVERSITY   (China)

^b Kangfu Hospital of Gansu Province   (China)

Author keywords

Acidithiobacillus ferrooxidans; Antitumor; Apoptosis; Bioleaching; Extraction; Realgar

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BIOLOGICAL PRODUCT; REALGAR; UNCLASSIFIED DRUG;

ACIDITHIOBACILLUS FERROOXIDANS; ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; BIOLEACHING; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER; MOUSE; NONHUMAN; SURVIVAL TIME;

ACIDITHIOBACILLUS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; FEMALE; HEP G2 CELLS; HUMANS; MALE; MICE; SULFIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ACIDITHIOBACILLUS FERROOXIDANS; BACTERIA (MICROORGANISMS); MUS; NEGIBACTERIA;

EID: 73949086065     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880200903029381     Document Type: Article

References (20)

1. Cetin Y, Bullerman LB (2005): Cytotoxicity of Fusarium mycotoxins to mammalian cell cultures as determined by the MTT bioassay. Food Chem Toxicol 43: 755-764.
2. Dilda PJ, Hogg PJ (2007): Arsenical-based cancer drugs. Cancer Treat Rev 33: 542-564.
3. Gilbertson BP (2000): Creating value through innovation biotechnology in mining. Miner Process Extr Metall 109: 61-67.
4. 2 on K562 cells and its mechanism. Acta Pharmacol Sinica 23: 991-996.
5. Lu DP, Qiu JY, Jiang B, Wang Q, Liu KY, Liu YR, Chen SS (2002): Tetraarsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood 99: 3136-3143.
6. Lu DP, Wang Q (2002): Current study of APL treatment in China. Int J Hematol 76: 1316-1318.
7. Mariko K, Kazunori K, Demidmaa T, Kenji I, Yasuji K, Kazuaki I, Terukatsu A (2002a): Inhibition by arsenic trioxide of human hepatoma cell growth. Cancer Lett 183: 147-153.
8. Mariko K, Yukihiro A, Nobuko O, Kunio Y, Yoshinori N (2002b): Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellular carcinoma cell lines. Biochem Biophy Res Commun 291: 861-867.
9. Prentis RA, Lis Y, Walker SR (1988): Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br J Clin Pharmacol 25: 387-396.
10. Rawlings DE (1998): Industrial practice and the biology of leaching of metals from ores. The 1997 Pan Labs Lecture. J Ind Microbiol Biotechnol 20: 268-274.
11. Sand W, Gehrke T, Jozsa PG, Schippers A (2001): Biochemistry of bacterial leaching-direct vs. indirect bioleaching. Hydrometallurgy 59: 159-175.
12. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89: 3354-3360.
13. Silverman MP, Lundgren DG (1959): Studies on the chemoautotrophic iron bacterium Ferrobacillus ferrooxidans. I: An improved medium and harvesting procedure for securing high cells yields. J Bacteriol 77: 1117-1121.
14. Siu KPY, Chan JYW, Fung KP (2002): Effect of arsenic trioxide on human hepatocellular carcinoma HepG2 cells: inhibition of proliferation and induction of apoptosis. Life Sci 71: 275-285.
15. 3 (orpiment). J Chromatogr A 1026: 261-270.
16. Wu XH, Sun DH, Zhuang ZX, Wang XR, Gong HF, Hong JX, Lee FSC (2002): Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal material. Anal Chim Acta 453: 311-323.
17. Xu LY, Zeng FD, Ye HQ, Yang XL, Xu HB (2006): Antitumor activity of realgar nanoparticles and the distribution of arsenic in tissues of tumor-transplanted mice. Chin J New Drugs 15: 1845-1849.
18. Zhang JH, Zhang X, Ni YQ, Yang XJ, Li HY (2007): Bioleaching of arsenic from medicinal realgar by pure and mixed cultures. Process Biochem 42: 1265-1271.
19. Zhang P, Wang SY, Hu XH (1996): Arsenic trioxide treated 72 cases of acute promyelocytic leukemia. Chin J Hematol 17: 58-62.
20. Zhen YY (2005). Chinese Pharmacopoeia, Part I. Beijing, Chemical Industry Press, pp. 236.