Contrast medium-enhanced radiation damage caused by CT examinations

Radiology

Volumn 253, Issue 3, 2009, Pages 706-714

  Grudzenski, Saskia ^a   Kuefner, Michael A ^b   Heckmann, Martina B ^b   Uder, Michael ^b   Löbrich, Markus ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GAMMA H2AX PROTEIN; HISTONE H2AX; IOMEPROL; IOPROMIDE; MANNITOL; UNCLASSIFIED DRUG; CONTRAST MEDIUM; DRUG DERIVATIVE; IOHEXOL; IOPAMIDOL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; FIBROBLAST CULTURE; GAMMA RADIATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IRRADIATION; LYMPHOCYTE CULTURE; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION INJURY; VENOUS BLOOD; X RAY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; FIBROBLAST; LYMPHOCYTE; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; STATISTICAL MODEL;

CONTRAST MEDIA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HUMANS; IOHEXOL; IOPAMIDOL; LINEAR MODELS; LYMPHOCYTES; PROSPECTIVE STUDIES; RADIATION DOSAGE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 73949085692     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.2533090468     Document Type: Article

References (29)

1. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and effects of ionizing radiation. New York, NY: United Nations, 2000.
2. 1990 Recommendations of the International Commission on Radiologic Protection. Ann ICRP 1991;21(1-3):1-201.
3. Brenner DJ. Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. Radiology 2004;231:440-445.
4. Brenner DJ, Elliston CD. Estimated radiation risks potentially associated with full-body CT screening. Radiology 2004;232:735-738.
5. Jeggo PA, Löbrich M. DNA double-strand breaks: their cellular and clinical impact. Oncogene 2007;26:7717-7719.
6. Löbrich M, Jeggo PA. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 2007;7:861-869.
7. Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999;146:905-916.
8. Rothkamm K, Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A 2003;100:5057-5062.
9. Löbrich M, Rief N, Kühne M, et al. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc Natl Acad Sci U S A 2005;102:8984-8989.
10. Geisel D, Heverhagen JT, Kalinowski M, Wagner HJ. DNA double-strand breaks after percutaneous transluminal angioplasty. Radiology 2008;248:852-859.
11. Rothkamm K, Balroop S, Shekhdar J, Fernie P, Goh V. Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure. Radiology 2007;242:244 -251.
12. Joubert A, Biston MC, Boudou C, et al. Irradiation in presence of iodinated contrast agent results in radiosensitization of endothelial cells: consequences for computed tomography therapy. Int J Radiat Oncol Biol Phys 2005;62:1486-1496.
13. Norman A, Cochran ST, Sayre JW. Meta-analysis of increases in micronuclei in peripheral blood lymphocytes after angiography or excretory urography. Radiat Res 2001;155:740-743.
14. Corde S, Joubert A, Adam JF, et al. Synchrotron radiation-based experimental determination of the optimal energy for cell radiotoxicity enhancement following photoelectric effect on stable iodinated compounds. Br J Cancer 2004;91:544-551.
15. Kegel P, Riballo E, Kühne M, Jeggo PA, Löbrich M. X-irradiation of cells on glass slides has a dose doubling impact. DNA Repair (Amst) 2007;6:1692-1697.
16. Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 2000;151:1381-1390.
17. Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 2003;278:19579-19582.
18. Deckbar D, Birraux J, Krempler A, et al. Chromosome breakage after G2 checkpoint release. J Cell Biol 2007;176:749-755.
19. Asakawa Y, Gotoh E. A method for detecting sister chromatid exchanges using prematurely condensed chromosomes and immunogold-silver staining. Mutagenesis 1997;12:175-177.
20. Adams FH, Norman A, Mello RS, Bass D. Effect of radiation and contrast media on chromosomes: preliminary report. Radiology 1977;124:823-826.
21. Matsubara S, Suzuki S, Suzuki H, Kuwabara Y, Okano T. Effects of contrast medium on radiation-induced chromosome aberrations. Radiology 1982;144:295-301.
22. Norman A, Adams FH, Riley RF. Cytogenetic effects of contrast media and triiodobenzoic acid derivatives in human lymphocytes. Radiology 1978;129:199-203.
23. Dawson P, Penhaligon M, Smith E, Saunders J. Synergistic cytotoxicity of iodinated contrast agents and x-radiation. Invest Radiol 1988;23(suppl 1):S110-S113.
24. Löbrich M, Kiefer J. Assessing the likelihood of severe side effects in radiotherapy. Int J Cancer 2006;118:2652-2656.
25. International Atomic Energy Agency. Cytogenetic analysis for radiation dose assessment: IAEA technical report series 405. Vienna, Austria: International Atomic Energy Agency, 2001.
26. Bauchinger M. Quantification of low-level radiation exposure by conventional chromosome aberration analysis. Mutat Res 1995;339:177-189.
27. Edwards AA, Lindholm C, Darroudi F, et al. Review of translocations detected by FISH for retrospective biological dosimetry applications. Radiat Prot Dosimetry 2005;113:396-402.
28. Kellerer AM. Electron spectra and the RBE of X rays. Radiat Res 2002;158:13-22.
29. Meesungnoen J, Jay-Gerin JP, Filali-Mouhim A, Mankhetkorn S. Low-energy electron penetration range in liquid water. Radiat Res 2002;158:657-660.