Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients

American Journal of Surgical Pathology

Volumn 34, Issue 1, 2010, Pages 75-87

  Cota, Carlo ^a,b   Vale, Esmeralda ^b   Viana, Isabel ^b   Requena, Luis ^c   Ferrara, Gerardo ^d   Anemona, Lucia ^e   Metze, Dieter ^f   Fink Puches, Regina ^a   Wiesner, Thomas ^a   Cerroni, Lorenzo ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c G RUMMO HOSPITAL   (Italy)

^d Centro de Dermatologia Medico Cirurgica   (Portugal)

^e Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^f UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Blastic plasmacytoid dendritic cell neoplasm; CD4+ CD56; Hematodermic neoplasm; Phenotype

Indexed keywords

TUMOR MARKER;

ADULT; AGED; ARTICLE; DENDRITIC CELL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKEMIA; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHENOTYPE; SKIN TUMOR;

ADULT; AGED; AGED, 80 AND OVER; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKEMIA; MALE; MIDDLE AGED; PHENOTYPE; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 73949084991     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181c5e26b     Document Type: Article

References (38)

1. Aoyama Y, Yamane T, Hino M, et al. Blastic NK-cell lymphoma/ leukemia with T-cell receptor gamma rearrangement. Ann Hematol. 2001;80:752-754.
2. Argyrakos T, Rontogianni D, Karmiris T, et al. Blastic natural killer (NK)-cell lymphoma: report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the literature. Leukem Lymph. 2004;45:2127-2133.
3. + hematodermic neoplasm: description of three cases. J Cutan Pathol. 2008;35:911-915.
4. Assaf C, Gellrich S, Whittaker S, et al. CD56-positive haematolo-gical neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer. J Clin Pathol. 2007;60:981-989.
5. + hemato-logical neoplasms presenting in the skin a retrospective analysis of 23 new cases and 130 cases from the literature. Ann Oncol. 2004;15:1097-1108.
6. Cerroni L, Smolle J, Soyer HP, et al. Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study. J Am Acad Dermatol. 1990;22:405-413.
7. Cerroni L, Gatter K, Kerl H. Skin Lymphoma. The Illustrated Guide. 3rd ed. Oxford: Wiley-Blackwell; 2009:191-198.
8. Chan JKC, Jaffe ES, Ralfkiaer E. Blastic NK-cell lymphoma. In: Jaffe ES, et al, eds. WHO Classification of Tumors. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001:214.
9. Chaperot L, Bendriss N, Manches O, et al. Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood. 2001;97:3210-3217.
10. Dijkman R, van Doom R, Szuhai K, et al. Gene-expression profiling and array-based CGH classify CD4CD56 hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities. Blood. 2007;109:1720-1727.
11. Facchetti F, Jones D, Petrella T. Blastic plasmacytoid dendritic cell neoplasm. In: Swerdlow SH, Campo E, Hazzis NL, et al, eds. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. Lyon: IARC press; 2008:145-147.
12. Facchetti F, Pileri SA, Agostinelli C, et al. Cytoplasmic nucleo-phosmin is not detected in blastic plasmacytoid dendritic cell neoplasm. Haematologica. 2009;94:285-288.
13. + malignancies. Blood. 2002;99:1556-1563.
14. Garnache-Ottou F, Feuillard J, Ferrand C, et al. Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia. Br J Haematol. 2009;145:624-636.
15. + hematodermic tumor. The features of an evolving entity and its relationship to dendritic cells. Am J Clin Pathol. 2007;127:687-700.
16. + hematodermic neoplasms. Mod Pathol. 2006;19:1555-1562.
17. + haematodermic neoplasm)? Br J Derma-tol. 2005;152:369-370.
18. Kazakov DV, Mentzel T, Burg G, et al. Blastic natural killer-cell lymphoma of the skin associated with myelodysplastic syndrome or myelogenous leukemia: a coincidence or more? Br J Dermatol. 2003;149:869-876.
19. +) blastic natural killer cell tumor of the skin: a primitive systemic malignancy related to myelomonocytic leukemia. Cancer. 2002;94: 2401-2408.
20. Liu XY, Atkins RC, Feusner JH, et al. Blastic NK-cell-like lymphoma with T-cell receptor gene rearrangement. Am J Hematol. 2004;75:251-253.
21. Marafioti T, Paterson JC, Ballabio E, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood. 2008;111:3778-3792.
22. Massone C, Chott A, Metze D, et al. Subcutaneous, blastic natural killer (NK), NK/T-cell, and other cytotoxic lymphomas of the skin. A morphologic, immunophenotypic, and molecular study of 50 patients. Am J Surg Pathol. 2004;28:719-735.
23. + blastic tumor cells express CD101 molecules. J Invest Dermatol. 2005;124:668-669.
24. Momoi A, Toba K, Kawai K, et al. Cutaneous lymphoblastic lymphoma of putative plasmacytoid dendritic-cell precursor origin: two cases. Leuk Res. 2002;26:693-698.
25. +, presenting in the skin: an increasingly recognized entity with an aggressive course. J Clin Oncol. 2001;19:2179-2188.
26. + hematodermic neoplasm (blastic NK-cell lymphoma): a report of five cases. Haematologica. 2006;91:143-144.
27. Niakosari F, Sur M. Agranular CD4/CD56 Hematodermic Neoplasm A Distinct Entity Described in the Recent World Health Organization-European Organization for Research and Treatment of Cancer Classification for Cutaneous Lymphomas. Arch Pathol Lab Med. 2007;131:149-151.
28. + malignancies. Eur J Dermatol. 2003;13:161-165.
29. + precursor cells related to plasmacytoid monocytes. Am J Surg Pathol. 2002;26:852-862.
30. Petrella T, Meijer CJLM, Dalac S, et al. TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis. Am J Clin Pathol. 2004;122: 307-313.
31. + haematodermic neoplasm). Br J Dermatol. 2004;150: 174-176. (Pubitemid 38234040)
32. + hematodermic neoplasms). A review. Am J Clin Pathol. 2005;123:662-675.
33. + hematodermic neoplasm ("blastic natural killer cell lymphoma"). Neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon. Am J Clin Pathol. 2007;128:445-453.
34. + lineage-negative malignancies are rare tumors of plasmacytoid dendritic cells. Am J Surg Pathol. 2005;29:1274-1283.
35. + hematodermic neoplasm: report of a rare variant with a T-cell receptor gene rearrangement. J Cutan Pathol. 2008;35:579-584.
36. Suzuki R, Nakamura S, Suzumiya J, et al. Blastic natural killer cell lymphoma/leukemia (CD56-positive blastic tumor). Prognostication and categorization according to anatomic sites of involvement. Cancer. 2005;104:1022-1031.
37. van Dongen JJM, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17: 2257-2317.
38. Willemze R, Jaffe ES, Burg G, et al. WHO-European Organization for the Research and Treatment of Cancer classification for cutaneous lymphomas. Blood. 2005;105:3768-3785.