Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding

Tissue Antigens

Volumn 75, Issue 2, 2010, Pages 136-150

  Gordon, K ^a   Balyasnikova, I V ^b,d   Nesterovitch, A B ^b   Schwartz, D E ^a   Sturrock, E D ^a   Danilov, S M ^b,c  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Angiotensin converting enzyme; Dimerization; Epitope mapping; Monoclonal antibody; N domain; Shedding

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3G8; MONOCLONAL ANTIBODY 9B9; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; DIMERIZATION; ENZYME ANALYSIS; EPITOPE MAPPING; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CARBOHYDRATES; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; EPITOPE MAPPING; EPITOPES; FEMALE; MUTATION; PEPTIDYL-DIPEPTIDASE A; PROTEIN MULTIMERIZATION;

CRICETULUS GRISEUS;

EID: 73949083200     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2009.01416.x     Document Type: Article

References (60)

1. Ehlers MR, Riordan JF. Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry 1989 : 28 : 5311 5318.
2. Skidgel RA, Erdos EG. Biochemistry of angiotensin I-converting enzyme. In: Robertson JIS, Nicholls MD, eds. The Renin-Angiotensin System, Vol. 1. Glower MedicalPublishing, London 1993, 10.1 10.10.
3. Corvol P, Eyries M, Soubrier F. Peptidyl-dipeptidase A/Angiotensin I-converting enzyme. In: Barret AA, Rawlings ND, Woessner JF, eds. Handbook of Proteolytic Enzymes. New York : Elsevier Academic Press, 2004, 332 349.
4. Dzau VJ, Bernstein K, Celermajer D et al. The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol 2001 : 88 : 1L 20L.
5. Caldwell PR, Seegal BC, Hsu KC, Das M, Soffer RL. Angiotensin-converting enzyme: vascular endothelial localization. Science 1976 : 191 : 1050 1051.
6. Balyasnikova IV, Danilov SM, Muzykantov VR, Fisher AB. Modulation of angiotensin-converting enzyme in cultured human vascular endothelial cells. In Vitro Cell Dev Biol Anim 1998 : 34 : 545 554.
7. Defendini R, Zimmerman EA, Weare JA, Alhenc-Gelas F, Erdös EG. Angiotensin-converting enzyme in epithelial and neuroepithelial cells. Neuroendocrinology 1983 : 37 : 32 40.
8. Hooper NM, Turner AJ. Isolation of two differentially glycosylated forms of peptidyldipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism. Biochem J 1987 : 241 : 625 633.
9. Silverstein E, Friedland J, Setton C. Angiotensin-converting enzyme in macrophages and Freund's adjuvant granuloma. Isr J Med Sci 1978 : 14 : 314 318.
10. Danilov SM, Sadovnikova E, Scharenborg N et al. Angiotensin-converting enzyme (CD143) is abundantly expressed by dendritic cells and discriminates human monocyte-derived dendritic cells from acute myeloid leukemia-derived dendritic cells. Exp Hematol 2003 : 31 : 1301 1309.
11. Danilov SM, Franke FE, Erdos EG. Angiotensin-converting enzyme (CD143). In: Kishimoto T et al., eds. Leucocyte Typing VI: White Cell Differentiation Antigens. New York : Garland Publishing Inc, 1997, 746 749.
12. Franke FE, Metzger R, Bohle R-M, Kerkman L, Alhenc-Gelas F, Danilov SM. Angiotensin I-converting enzyme (CD 143) on endothelial cells in normal and in pathological conditions. In: Kishimoto T et al eds. Leucocyte Typing VI: White Cell DifferentiationAntigens. New York: Garland Publishing Inc, 1997, 749 751.
13. Soubrier F, Alhenc-Gelas F, Hubert C et al. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci U S A 1988 : 85 : 9386 9390.
14. Corradi HR, Schwager SL, Nchinda AT, Sturrock ED, Acharya KR. Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. J Mol Biol 2006 : 357 : 964 974.
15. Balyasnikova IV, Skirgello OE, Binevski PV et al. Monoclonal Antibodies 1G12 and 6A12 to the N-domain of human angiotensin-converting enzyme: fine epitope mapping and antibody-based detection of ACE inhibitors in human blood. J Proteome Res 2007 : 6 : 1580 1594.
16. Natesh R, Schwager SL, Sturrock ED, Acharya KR. Crystal structure of the human angiotensin-converting enzyme-lisinopril complex. Nature 2003 : 421 : 551 554.
17. Naperova IA, Balyasnikova IV, Schwartz DE et al. Mapping of conformational mAb epitopes to the C domain of human angiotensin I-converting enzyme. J Proteome Res 2008 : 7 : 3396 3411.
18. Balyasnikova IV, Woodman ZL, Albrecht RF et al. Localization of an N-domain region of angiotensin-converting enzyme involved in the regulation of ectodomain shedding using monoclonal antibodies. J Proteome Res 2005 : 4 : 258 267.
19. Balyasnikova IV, Sun ZL, Franke FE et al. Monoclonal antibodies 1B3 and 5C8 as probes for monitoring the integrity of the C-terminal end of soluble angiotensin-converting enzyme. Hybridoma (Larchmt) 2005 : 24 : 14 26.
20. Skirgello OE, Balyasnikova IV, Binevski PV et al. Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action. Biochemistry 2006 : 45 : 4831 4847.
21. Danilov SM, Watermeyer JM, Balyasnikova IV et al. Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme. Biochemistry 2007 : 46 : 9019 9031.
22. Balyasnikova IV, Metzger R, Franke FE et al. Epitope mapping of mAbs to denatured human testicular ACE (CD143). Tissue Antigens 2008 : 72 : 354 368.
23. Danilov S, Jaspard E, Churakova T et al. Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site. J Biol Chem 1994 : 269 : 26806 26814.
24. Balyasnikova IV, Karran EH, Albrecht RF, Danilov SM. Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. Biochem J 2002 : 362 : 585 595.
25. Danilov SM, Deinum J, Balyasnikova IV et al. Detection of mutated angiotensin I-converting enzyme by serum/plasma analysis using a pair of monoclonal antibodies. Clin Chem 2005 : 51 : 1040 1043.
26. Kost OA, Balyasnikova IV, Chemodanova EE, Nikolskaya II, Albrecht RF, Danilov SM. Epitope-dependent blocking of the angiotensin-converting enzyme dimerization by monoclonal antibodies to the N-terminal domain of ACE: possible link of ACE dimerization and shedding from the cell surface. Biochemistry 2003 : 42 : 6965 6976.
27. Balyasnikova IV, Metzger R, Franke FE, Danilov SM. Monoclonal antibodies to denatured human ACE (CD 143), broad species specificity, reactivity on paraffin sections, and detection of subtle conformational changes in the C-terminal domain of ACE. Tissue Antigens 2003 : 61 : 49 62.
28. Danilov SM, Faerman AI, Printseva OYu, Martynov AV, Sakharov IYu, Trakht IN. Immunohistochemical study of angiotensin-converting enzyme in human tissues using monoclonal antibodies. Histochemistry 1987 : 87 : 487 490.
29. Metzger R, Bohle RM, Pauls K et al. Angiotensin-converting enzyme in non-neoplastic kidney diseases. Kidney Int 1999 : 56 : 1442 1454.
30. Metzger R, Bohle RM, Chumachenko P, Danilov SM, Franke FE. CD143 in the development of atherosclerosis. Atherosclerosis 2000 : 150 : 21 31.
31. Franke FE, Pauls K, Kerkman L et al. Somatic isoform of angiotensin I-converting enzyme in the pathology of testicular germ cell tumors. Hum Pathol 2000 : 31 : 1466 1476.
32. Pauls K, Metzger R, Steger K, Klonisch T, Danilov S, Franke FE. Isoforms of angiotensin I-converting enzyme in the development and differentiation of human testis and epididymis. Andrologia 2003 : 35 : 32 43. (Pubitemid 36250102)
33. Danilov S, Savoie F, Lenoir B et al. Development of enzyme-linked immunoassays for human angiotensin I converting enzyme suitable for large-scale studies. J Hypertens 1996 : 14 : 719 727.
34. Danilov SM, Martynov AV, Klibanov AL et al. Radioimmunoimaging of lung vessels: an approach using indium-111-labeled monoclonal antibody to angiotensin-converting enzyme. J Nucl Med 1989 : 30 : 1686 1692.
35. Muzykantov VR, Danilov SM. Targeting of radiolabelled monoclonal antibody against angiotensin-converting enzyme to the pulmonary vasculature. In: Torchilin VP, ed. Handbook of Targeting Delivery of Imaging Agents. Boca Raton : CRC, 1995, 465 486.
36. Danilov SM, Muzykantov VR, Martynov AV et al. Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme. Lab Invest 1991 : 64 : 118 124.
37. Muzykantov VR, Atochina EN, Ischiropoulos H, Danilov SM, Fisher AB. Immunotargeting of antioxidant enzyme to the pulmonary endothelium. Proc Natl Acad Sci U S A 1996 : 93 : 5213 5218.
38. Nowak K, Weih S, Metzger R et al. Immunotargeting of catalase to lung endothelium via anti-angiotensin-converting enzyme antibodies attenuates ischemia-reperfusion injury of the lung in vivo. Am J Physiol Lung Cell Mol Physiol 2007 : 293 : L162 9.
39. Reynolds PN, Zinn KR, Gavrilyuk VD et al. A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. Mol Ther 2000 : 2 : 562 578.
40. Miller WH, Brosnan MJ, Graham D et al. Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Mol Ther 2005 : 12 : 321 327.
41. Reynolds AM, Xia W, Holmes MD et al. Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2007 : 292 : L1182 92.
42. Balyasnikova IV, Gavriljuk VD, McDonald TD, Berkowitz R, Miletich TJ, Danilov SM. Antibody-mediated lung endothelium targeting: in vitro model using a cell line expressing angiotensin-converting enzyme. Tumor Target 1999 : 4 : 70 83.
43. Balyasnikova IV, Yeomans DC, McDonald TB, Danilov SM. Antibody-mediated lung endothelium targeting: in vivo model on primates. Gene Ther 2002 : 9 : 282 290.
44. Wei L, Alhenc-Gelas F, Corvol P, Clauser E. The two homologous domains of human angiotensin I-converting enzyme are both catalytically active. J Biol Chem 1991 : 266 : 9002 9032.
45. Flaherty DM, Monick MM, Hinde SL. Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants. J Biol Chem 2006 : 281 : 5058 5064.
46. Piquilloud Y, Reinharz A, Roth M. Studies on the angiotensin converting enzyme with different substrates. Biochim Biophys Acta 1970 : 206 : 136 142.
47. Friedland J, Silverstein E. Sensitive fluorimetric assay for serum angiotensin-converting enzyme with the natural substrate angiotensin I. Am J Clin Pathol 1977 : 68 : 225 228.
48. Ehlers MR, Chen YN, Riordan JF. Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells. Protein Expr Purif 1991 : 2 : 1 9.
49. Mylvaganam SE, Paterson Y, Getzoff ED. Structural basis for the binding of an anti-cytochrome c antibody to its antigen: crystal structures of FabE8-cytochrome c complex to 1.8 A resolution and FabE8 to 2.26 A resolution. J Mol Biol 1998 : 281 : 301 322.
50. Huang M, Syed R, Stura EA et al. The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. J Mol Biol 1998 : 275 : 873 894.
51. Kohlstedt K, Gershome C, Friedrich M et al. Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells. Mol Pharmacol 2006 : 69 : 1725 1732.
52. Sun X, Wiesner B, Lorenz D et al. Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE. Biol Chem 2008 : 389 : 1477 1485.
53. Ehlers MR, Chen YN, Riordan JF. The unique N-terminal sequence of testis angiotensin-converting enzyme is heavily O-glycosylated and unessential for activity or stability. Biochem Biophys Res Commun 1992 : 183 : 199 205.
54. Kasturi S, Jabbar MA, Sen GC, Sen I. Role of glycosylation in the biosynthesis and activity of rabbit testicular angiotensin-converting enzyme. Biochemistry 1994 : 33 : 6228 6234.
55. Takeda S, Igarashi T, Mori H, Araki S. Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. EMBO J 2006 : 25 : 2388 2396.
56. Woodman ZL, Schwager SL, Redelinghuys P, Carmona AK, Ehlers MR, Sturrock ED. The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity. Biochem J 2005 : 389 : 739 744.
57. Woodman ZL, Oppong SY, Cook S, Hooper NM, Schwager SL. Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites. Biochem J 2000 : 347 (Pt 3) : 711 718.
58. Michineau S, Alhenc-Gelas F, Rajerison RM. Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization. Biochemistry 2006 : 45 : 2699 2707.
59. Claffey KP, Senger DR, Spiegelman BM. Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF. Biochim Biophys Acta 1995 : 1246 : 1 9.
60. Siemeister G, Marmé D, Martiny-Baron G. The alpha-helical domain near the amino terminus is essential for dimerization of vascular endothelial growth factor. J Biol Chem 1998 : 273 : 11115 11120.