In vivo selection of imipenem-resistant Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-15 and plasmid-encoded DHA-1 cephalosporinase

International Journal of Antimicrobial Agents

Volumn 35, Issue 3, 2010, Pages 265-268

  Cuzon, Gaelle ^a   Naas, Thierry ^a   Guibert, Michele ^b   Nordmann, Patrice ^a  

^a BICÊTRE HOSPITAL   (France)

^b HÔPITAL ANTOINE BÉCLÈRE   (France)

Author keywords

AmpC; Antimicrobial resistance mechanisms; Carbapenem resistance; Carbapenems; ESBL; Multidrug resistance; OMPs; Outer membrane proteins

Indexed keywords

AMPHOTERICIN B; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE AMPC; BETA LACTAMASE CTX M 15; BETA LACTAMASE DHA 1; BETA LACTAMASE TEM 1; CARBAPENEM DERIVATIVE; CEFEPIME; CEFTAZIDIME; CEPHAMYCIN; CLOXACILLIN; COLISTIN; HYDROLASE; IMIPENEM; TIGECYCLINE; TIMENTIN; UNCLASSIFIED DRUG;

AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CANDIDA TROPICALIS; CANDIDEMIA; CASE REPORT; DRUG EXPOSURE; DRUG HYDROLYSIS; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE EXPRESSION; HUMAN; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POINT MUTATION; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BACTERIAL TYPING TECHNIQUES; BETA-LACTAMASES; DNA FINGERPRINTING; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; IMIPENEM; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PLASMIDS; SELECTION, GENETIC;

EID: 73849147547     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2009.10.021     Document Type: Article

References (15)

1. Queenan A.M., and Bush K. Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev 20 (2007) 440-458
2. ACT-1 β-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoE. Antimicrob Agents Chemother 50 (2006) 3396-3406
3. Mena A., Plasencia V., García L., Hidalgo O., Ayestarán J.I., Alberti S., et al. Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development. J Clin Microbiol 44 (2006) 2831-2837
4. Martínez-Martínez L., and Extended-spectrum. β-lactamases and the permeability barrier. Clin Microbiol Infect 14 Suppl. 1 (2008) 82-89
5. Nordmann P., Cuzon G., and Naas T. The real threat of KPC carbapenemase-producing bacteria. Lancet Infect Dis 9 (2009) 228-236
6. KPC gene. Antimicrob Agents Chemother 52 (2008) 1257-1263
7. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Fifteenth informational supplement. Document M100-S15. Wayne, PA: CLSI; 2005.
8. Drieux L., Brossier F., Sougakoff W., and Jarlier V. Phenotypic detection of extended-spectrum β-lactamase production in Enterobacteriaceae: review and bench guide. Clin Microbiol Infect 14 Suppl. 1 (2008) 90-103
9. Cuzon G., Naas T., Demachy M.C., and Nordmann P. Plasmid-mediated carbapenem-hydrolyzing β-lactamase KPC-2 in Klebsiella pneumoniae from Greece. Antimicrob Agents Chemother 52 (2008) 796-797
10. Filip C., Fletcher G., Wulff J.L., and Earhart C.F. Solubilization of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium-lauryl sarcosinate. J Bacteriol 115 (1973) 717-722
11. TEM-67 from Proteus mirabilis, into the Escherichia coli chromosome. Antimicrob Agents Chemother 47 (2003) 19-26
12. Elliott E., Brink A.J., van Greune J., Els Z., Woodford N., Turton J., et al. In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase. Clin Infect Dis 42 (2006) e95-e98
13. Lee C.H., Chia J.H., Chu C., Wu T.L., Liu J.W., and Su L.H. In vivo selection of OmpK35-deficient mutant after cefuroxime therapy for primary liver abscess caused by Klebsiella pneumoniae. J Antimicrob Chemother 58 (2006) 857-860
14. DHA-1 leading to ertapenem resistance in a clinical isolate of Klebsiella pneumoniae producing CTX-M-3 and SHV-5 β-lactamases. J Antimicrob Chemother 60 (2007) 410-413
15. Mata C., Miró E., Rivera A., Mirelis B., Coll P., and Navarro F. Prevalence of acquired AmpC β-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007. Clin Microbiol Infect (2009) 10.1111/j.1469-0691.2009.02864.x [Epub ahead of print]