The herbal medicine Daikenchuto increases blood flow in the superior mesenteric artery

Tohoku Journal of Experimental Medicine

Volumn 219, Issue 4, 2009, Pages 319-330

  Takayama, Shin ^a   Seki, Takashi ^a   Watanabe, Masashi ^a   Monma, Yasutake ^a   Sugita, Norihiro ^b   Konno, Satoshi ^b   Iwasaki, Koh ^a   Takeda, Takashi ^a   Yambe, Tomoyuki ^b   Yoshizawa, Makoto ^b   Nitta, Shin Ichi ^b   Yaegashi, Nobuo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Daikenchuto; Hemodynamics; Herbal medicine; Superior mesenteric artery; Ultrasound

Indexed keywords

DAIKENCHUTO; HERBACEOUS AGENT; ORENGEDOKUTO; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ARTERY BLOOD FLOW; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VOLUME; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFICACY; HEART OUTPUT; HEART RATE; HEMODYNAMIC PARAMETERS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SUPERIOR MESENTERIC ARTERY;

ADULT; BLOOD PRESSURE; BLOOD VOLUME; CARDIAC OUTPUT; HEART RATE; HERBAL MEDICINE; HUMANS; MALE; MESENTERIC ARTERY, SUPERIOR; MIDDLE AGED; PLANT EXTRACTS; PULSATILE FLOW; REGIONAL BLOOD FLOW;

EID: 73849122807     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.219.319     Document Type: Article

References (34)

1. Albert, N.M., Hail, M.D., Li, J. & Young, J.B. (2004) Equivalence of the bioimpedance and thermodilution methods in measuring cardiac output in hospitalized patients with advanced, decompensated chronic heart failure. Am. J. Crit. Care, 13, 469-479.
2. Anzueto Hernandez, L., Kvietys, P.R. & Granger, D.N. (1986) Postprandial hemodynamics in the conscious rat. Am. J. Physiol., 251, G117-123.
3. Arakawa, K., Saruta, T., Abe, K., Iimura, O., Ishii, M., Ogihara, T., Hiwada, K., Fukiyama, K., Fujishima, M., Mizuno, Y., Kikuchi, T. & Takaori S. (2006) Improvement of accessory symptoms of hypertension by TSUMURA Orengedokuto Extract, a four herbal drugs containing Kampo-Medicine Granules for ethical use: a double-blind, placebo-controlled study. Phytomedicine, 13, 1-10.
4. Burns, P.N. & Jaffe, C.C. (1985) Quantitative flow measurements with Doppler ultrasound: techniques, accuracy, and limitations. Radiol. Clin. North. Am., 23, 641-657.
5. Byrne, M.F., Farrell, M.A., Abass, S., Fitzgerald, A., Varghese, J.C., Thornton, F. Murray, F.E. & Lee, M.J. (2001) Assessment of Crohn's disease activity by Doppler sonography of the superior mesenteric artery, clinical evaluation and the Crohn's disease activity index: a prospective study. Clin. Radiol., 56, 973-978.
6. Endo, S., Nishida, T., Nishikawa, K., Nakajima, K., Hasegawa, J., Kitagawa, T., Ito, T. & Matsuda, H. (2006) Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition. Am. J. Surg., 192, 9-13.
7. Erden, A., Cumhur, T. & Olcer, T. (1997) Superior mesenteric artery Doppler waveform changes in response to inflammation of the ileocecal region. Abdom. Imaging, 22, 483-486.
8. Gallavan, R.H. Jr. & Chou, C.C. (1985) Possible mechanisms for the initiation and maintenance of postprandial intestinal hyperemia. Am. J. Physiol., 249, G301-308.
9. Gill, R.W. (1985) Measurement of blood flow by ultrasound: accuracy and sources of error. Ultrasound Med. Biol., 11, 625-641.
10. Jin, X.L., Shibata, C., Naito, H., Ueno, T., Funayama, Y., Fukushima, K., Matsuno, S. & Sasaki, I. (2001) Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs. Dig. Dis. Sci., 46, 1171-1176.
11. Kee, C.H.W. & Michael, W. (1998) The Pharmacology of Chinese Herbs. 2nd ed., CRC Press LLC, New York, pp. 164-381.
12. Kono, T., Koseki, T., Chiba, S., Ebisawa, Y., Chisato, N., Iwamoto, J. & Kasai, S. (2008) Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1. J. Surg. Res., 150, 78-84.
13. Miura, N., Fukutake, M., Yamamoto, M., Ohtake, N., Iizuka, S., Imamura, S., Tsuchiya, N., Ishimatsu, M., Nakamura, Y., Ishige, A., Watanabe, K., Kase, Y. & Takeda, S. (2007) An herbal medicine orengedokuto prevents indomethacin-induced enteropathy. Biol. Pharm. Bull., 30, 495-501.
14. Moneta, G.L., Taylor, D.C., Helton, W.S., Mulholland, M.W. & Strandness, D.E. Jr. (1988) Duplex ultrasound measurement of postprandial intestinal blood flow: effect of meal composition. Gastroenterology, 95, 1294-1301.
15. Murata, P., Kase, Y., Ishige, A., Sasaki, H., Kurosawa, S. & Nakamura, T. (2002) The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. Life Sci., 70, 2061-2070.
16. Nagano, T., Itoh, H. & Takeyama, M. (2000) Effects of Dai-kenchu-to on levels of 5-hydroxytryptamine (serotonin) and vasoactive intestinal peptides in human plasma. Biol. Pharm. Bull., 23, 352-353.
17. Ogasawara, T., Morine, Y., Ikemoto, T., Imura, S., Fujii, M., Soejima, Y. & Shimada, M. (2008) Influence of Dai-kenchu-to (DKT) on human portal blood flow. Hepatogastroenterology, 55, 574-577.
18. Perrino, A.C. Jr., Lippman, A., Ariyan, C., O'Connor, T.Z. & Luther, M. (1994) Intraoperative cardiac output monitoring: comparison of impedance cardiography and thermodilution. J. Cardiothorac. Vasc. Anesth., 8, 24-29.
19. Sato, Y., Hanawa, T., Arai, M., Cyong, J., Fukuzawa, M., Mitani, K., Ogihara, Y., Sakiyama, T., Shimada, Y., Toriizuka, K. & Yamada, T. (2005) Introduction to KAMPO Japanese Traditional Medicine. 1st ed., Elsevier Japan K.K., Tokyo, pp. 87-124.
20. Sato, Y., Katagiri, F., Inoue, S., Itoh, H. & Takeyama, M. (2004) Dai-kenchu-to raises levels of calcitonin gene-rerated peptide and substance P in human plasma. Biol. Pharm. Bull., 27, 1875-1877.
21. Schmidt, P. & Holst, J.J. (2000) Tachykinins in regulation of gastric motility and secretion. Cell. Mol. Life Sci., 57, 579-588.
22. Sigirci, A., Baysal, T., Kutlu, R., Aladag, M., Sarac, K. & Harputluoglu, H. (2001) Doppler sonography of the inferior and superior mesenteric arteries in ulcerative colitis. J. Clin. Ultrasound, 29, 130-139.
23. Siregar, H. & Chou, C.C. (1982) Relative contribution of fat, protein, carbohydrate, and ethanol to intestinal hyperemia. Am. J. Physiol., 242, G27-31.
24. Springfield, C.L., Sebat, F., Johnson, D., Lengle, S. & Sebat, C. (2004) Utility of impedance cardiography to determine cardiac vs. noncardiac cause of dyspnea in the emergency department. Congest. Heart Fail., 10, 14-16.
25. Strobeck, J.E. & Silver, M.A. (2004) Beyond the four quadrants: the critical and emerging role of impedance cardiography in heart failure. Congest. Heart Fail., 10, 1-6.
26. Takayama, S., Seki, T., Watanabe, M., Takashima, S., Sugita, N., Konno, S., Takeda, T., Arai, H., Yambe, T., Yaegashi, N., Yoshizawa, M., Maruyama, S. & Nitta, S. (2009a) Changes of blood flow volume in the superior mesenteric artery and brachial artery with abdominal thermal stimulation. Evid. Based Complement. Alternat. Med., [Epub ahead of print]
27. Takayama, S., Seki, T., Sugita, N., Konno, S., Arai, H., Saijo, Y., Yambe, T., Yaegashi, N., Yoshizawa, M. & Nitta, S. (2009b) Effect of acupuncture on radial artery blood flow volume: hemodynamic changes related to acupuncture. Explore (NY), [in press]
28. Takayama, S., Seki, T., Watanabe, M., Monma, Y., Yang, S., Sugita, N., Konno, S., Saijo, Y., Yambe, T., Yaegashi, N., Yoshizawa, M. & Nitta, S. (2009c) The brief effect of acupuncture on the peripheral arterial system of the upper limb and systemic hemodynamics in humans. J. Altern. Complement. Med., [in press]
29. Tokita, Y., Yuzurihara, M., Sakaguchi, M., Satoh, K. & Kase, Y. (2007) The pharmacological effects of Daikenchuto, a traditional herbal medicine, on delayed gastrointestinal transit in rat postoperative ileus. J. Pharmacol. Sci., 104, 303-310.
30. Taylor, K.J. & Holland, S. (1990) Doppler US. Part I. Basic principles, instrumentation, and pitfalls. Radiology, 174, 297-307.
31. Van Bel, F., Van Zwieten, P.H., Guit, G.L. & Schipper, J. (1990) Superior mesenteric artery blood flow velocity and estimated volume flow: duplex Doppler US study of preterm and term neonates. Radiology, 174, 165-169.
32. Vijayan, K.K. & Ajithan-Thampuran, R.V.A. (2000) Black Pepper, Piper Nigram: Piper nigrum, edited by P.N. Harwood Academic Publishing, USA, pp. 455-466.
33. Yamaya, M., Yanai, M., Ohrui, T., Arai, H. & Sasaki, H. (2001) Interventions to prevent pneumonia among older adults. J. Am. Geriatr. Soc., 49, 85-90.
34. Zhou, H. & Mineshita, S. (1999) The effect of Oren-gedoku-to on experimental colitis in rats. J. Pharm. Pharmacol., 51, 1065-1074.