Methodology and purposes of establishing mouse and rat models for syndrome differentiation and treatment

Journal of Chinese Integrative Medicine

Volumn 7, Issue 10, 2009, Pages 907-912

  Fang, Zhao Qin ^a   Pan, Zhi Qiang ^a   Lu, Wen Li ^a   Liu, Xiao Mei ^a   Guan, Dong Yuan ^a   Liang, Chao ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Disease; Drug property; Mice; Objective four diagnostic methods; Rats; Symptom complex; Syndrome differentiation; Syndrome differentiation treatment

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; CHINESE MEDICINE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SIMULATION; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; GENE EXPRESSION; IMMUNE SYSTEM; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; QUANTITATIVE STUDY; RAT; REVIEW; STANDARDIZATION; SYMPTOMATOLOGY; ANIMAL; DIFFERENTIAL DIAGNOSIS; HUMAN; PROCEDURES; SYNDROME;

HERBACEOUS AGENT;

ANIMALS; DIAGNOSIS, DIFFERENTIAL; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; HUMANS; MEDICINE, CHINESE TRADITIONAL; MICE; RATS; SYNDROME;

EID: 73849118530     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20091002     Document Type: Review

References (31)

1. Fang ZQ, Pan ZQ, Lu WL, Liu ZM, Guan DY, Liang C. Research and development on syndromes and methodology of syndromes differentiation and treatment in rats and mice. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2008; 22(4): 12-16. Chinese with abstract in English.
2. Fang ZQ, Pan ZQ, Chen X, Lu WL, Fu XL, Hou L. Construction and significance of four diagnostic methodology about experiment mice. Shanghai Zhong Yi Yao Za Zhi. 2006; 40(7): 1-4, Cover 3. Chinese with abstract in English.
3. Fang ZQ, Pan ZQ, Lu WL, Liu XM, Hou L, Liao MJ. Establishment and evaluation of metrological methods of syndrome differentiation about common syndrome in rats and mice. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2007; 13(7): 502-505. Chinese with abstract in English.
4. Fang ZQ. Discussion on some basic academic problems in research and development of treatment based on syndrome differentiation. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008; 28(7): 652-655. Chinese with abstract in English.
5. Chen X, Chen DS, Fang ZQ. Control study of non-traumatic parameters of syndrome differentiation in tumor-bearing mice. Zhong Yi Za Zhi. 2003; 44(1): 58-59. Chinese.
6. Pan ZQ, Fang ZQ, Kan WB, Chen X, Fu XL, Wu ZH, Wang SM, Xu JT. Hind paw atlas and RGB analysis of normal Kunming mice. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2003; 17(3): 46-48. Chinese with abstract in English.
7. Pan ZQ, Fang ZQ, Kan WB, Chen X, Fu XL, Wu ZH, Wang SM, Xu JT. Signing atlases of Zheng on hind paws in tumor-bearing mice. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2004; 10(2): 27-29. Chinese with abstract in English.
8. Pan ZQ, Fang ZQ, Fu XL, Kan WB. Evolution of typical Syndromes and the characteristics of hind paw images in tumor-bearing mice. Shanghai Zhong Yi Yao Za Zhi. 2004; 10(6): 62-64, F003. Chinese with abstract in English.
9. Pan ZQ, Lu WL, Fang ZQ. Shooting picture of the tongue about mice in microscope. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2007; 13(3): 189-191. Chinese with abstract in English.
10. Lu WL, Fang ZQ, Pan ZQ, Fu XL. Comparison and evaluation of mouse models for four methods of examination in differentiation of eight syndromes such as qi, blood, yin or yang deficiency. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2006; 12(6): 433-438. Chinese.
11. Lu WL, Fang ZQ, Pan ZQ, Hou L. Comparison and analysis of qi and blood deficiency syndrome models in four species of mice. Liaoning Zhong Yi Za Zhi. 2007; 34(4): 519-522. Chinese with abstract in English.
12. Fang ZQ, Pan ZQ, Fu XL, Lu WL, Chen X, Tang WC, Kan WB, Xu M. The proposal of criterion on mice' four diagnostic methods collecting item. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2005; 11(9): 692-694. Chinese with abstract in English.
13. Fang ZQ, Pan ZQ, Tang WC, Fu XL, Lu WL, Chen X. Construction and operational standard of four diagnostic methods workstation for mice. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2006; 20(1): 42-46. Chinese with abstract in English.
14. Fang ZQ, Pan ZQ, Lu WL, Fu XL, Chen X, Tang WC, Kan WB, Xu M. Differentiation of symptoms standard of common symptoms in mice. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2006; 12(7): 508-510. Chinese.
15. Pan ZQ, Fang ZQ, Lu WL. Comparative research on syndrome manifestation features in mice with H22 liver cancer and Lewis lung carcinoma. Beijing Zhong Yi Yao Da Xue Xue Bao. 2008; 31(3): 184-188. Chinese with abstract in English.
16. Pan ZQ, Fang ZQ, Lu WL. Research of symptoms and signs in nude mice with tumour. Liaoning Zhong Yi Yao Da Xue Xue Bao. 2008; 10(9): 135-138. Chinese with abstract in English.
17. Lu WL, Fang ZQ, Pan ZQ, Hou L, Liu XM. Syndrome characteristics and comparison of six kinds of mice gastrelceosis models. Shanghai Zhong Yi Yao Za Zhi. 2007; 41(8): 63-68. Chinese with abstract in English.
18. Lu WL, Fang ZQ, Pan ZQ, Liu XM. Syndrome characteristics and comparison of rat ' s gastrelceosis models induced by stress or other factors. Fujian Zhong Yi Yao. 2008; 39(2): 45-48. Chinese.
19. Liu XM, Fang ZQ, Lu WL, Pan ZQ, Shu S. Characteristic and development of syndrome about diabetes mellitus rats. Liaoning Zhong Yi Za Zhi. 2008; 35(1): 130-134. Chinese with abstract in English.
20. Liu XM, Fang ZQ, Pan ZQ, Lu WL, Shu S, Song LN. Comparison between syndromes in hyperlipemia rats fed with two fat-rich diets. Anhui Zhong Yi Xue Yuan Xue Bao. 2008; 27(2): 33-37. Chinese with abstract in English.
21. Lu WL, Fang ZQ, Pan ZQ, Liu XM, Xiao Y, Yuan YL. The syndrome characters and comparison of three kinds of hypertensive rat models. Sichuan Zhong Yi. 2008; 26(11): 25-28. Chinese with abstract in English.
22. Fang ZQ, Pan ZQ, Lu WL, Liang C, Wu ZH, Liu XM, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF. General characteristics of gene transcription of neuroendocrine and immune tissues of common syndromes in tumor-bearing mice. Shanghai Zhong Yi Yao Za Zhi. 2009; 43(1): 68-74. Chinese with abstract in English.
23. Pan ZQ, Fang ZQ, Lu WL, Liang C, Wu ZH, Liu XM, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF. Difference of gene expression in adrenal gland of H22 tumour mice of yang-qi deficiency syndrome and qi-yin-yang deficiency syndrome. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2008; 22(3): 45-50. Chinese with abstract in English.
24. Pan ZQ, Fang ZQ, Lu WL, Liang C, Wu ZH, Liu XM, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF. Differentially expressed genes in adrenal gland of H22 liver cancer mice with different syndromes and in different stages. J Chin Integr Med. 2008; 6(8): 843-851. Chinese with abstract in English.
25. Liu XM, Fang ZQ, Pan ZQ, Lu WL, Liang C, Wu ZH, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF. Up- and down-regulated genes in pituitary of tumour mice of poisonous pathogenic factors syndrome and asthenia of qi syndrome. Zhejiang Zhong Xi Yi Jie He Za Zhi. 2008; 18(11): 664-666. Chinese with abstract in English.
26. Liu XM, Fang ZQ, Pan ZQ, Lu WL, Liang C, Wu ZH, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF. Coincident up- or down-regulated genes in pituitary of H22 tumor-bearing mice of different syndromes. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2008; 22(4): 75-79. Chinese with abstract in English.
27. Zhuo SY, Fang ZQ, Lu WL, Pan ZQ, Wu ZH, Liang C, Liu XM, Hou L, Zhang H, Liao MJ, Gao BF. Characteristic of gene transcription of tumorous ABC transporter family in H22 tumor-bearing mice with different syndromes. Guangxi Zhong Yi Yao. 2008; 31 (1): 48-53. Chinese with abstract in English.
28. Pan ZQ, Fu XL, Fang ZQ. Further research of syndrome differentiation and treatment in tumor-bearing mice. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2007; 13(1): 28-31. Chinese.
29. Xiao Y, Fang ZQ, Pan ZQ, Lu WL, Yuan YL, Chen BY, Hou L, Liao MJ. Individuation of syndrome differentiation and treatment in H22 tumor-bearing mice. Zhonghua Zhong Yi Yao Xue Kan. 2008; 26(7): 1486-1488. Chinese.
30. Fang ZQ, Hou L, Lu WL, Pan ZQ, Liao MJ, Xiao Y. Occurrence, development, accompanying symptoms and prognosis of syndromes in tumor-bearing mice. Shanghai Zhong Yi Yao Za Zhi. 2007; 41(1): 57-62. Chinese with abstract in English.
31. Fang ZQ, Pan ZQ, Lu WL. Establishment and development of evaluation platform for medicine nature of Chinese herbs. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2008; 14(8): 629-631. Chinese.