A population genetics study of the familial mediterranean fever gene: Evidence of balancing selection under an overdominance regime

Genes and Immunity

Volumn 10, Issue 8, 2009, Pages 678-686

  Fumagalli, M ^a,b   Cagliani, R ^a   Pozzoli, U ^a   Riva, S ^a   Comi, G P ^c   Menozzi, G ^a   Bresolin, N ^a,b   Sironi, M ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b POLITECNICO DI MILANO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Balancing selection; Familial Mediterranean Fever; Heterozygote advantage

Indexed keywords

GENE PRODUCT; MEDITERRANEAN FEVER PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; ASIA; CONTROLLED STUDY; EUROPE; EXON; FAMILIAL MEDITERRANEAN FEVER; GENEALOGY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HUMAN; MOLECULAR EVOLUTION; POPULATION DIFFERENTIATION; POPULATION GENETICS; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

3' UNTRANSLATED REGIONS; ANIMALS; CYTOSKELETAL PROTEINS; EXONS; FAMILIAL MEDITERRANEAN FEVER; GENETICS, POPULATION; HAPLOTYPES; HUMANS; PAN TROGLODYTES; SELECTION, GENETIC;

PRIMATES;

EID: 73849112043     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2009.59     Document Type: Article

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