Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors

Journal of Biotechnology

Volumn 145, Issue 3, 2010, Pages 295-303

  Gong, Li Li ^a   Fang, Lian Hua ^a   Peng, Jian Hao ^a   Liu, Ai Lin ^a   Du, Guan Hua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

High throughput screening; LigandFit; Pharmacophore; Rho kinase; Virtual screening

Indexed keywords

HIGH-THROUGHPUT SCREENING; KINASE ASSAYS; NEW HIGH; PHARMACOPHORE MODELS; PHARMACOPHORES; RHO-KINASE INHIBITORS; VIRTUAL SCREENING;

INTEGRATION; PHARMACODYNAMICS;

THROUGHPUT;

4 (1 AMINOETHYL) N (1H PYRROLO[2,3 B]PYRIDIN 4 YL)CYCLOHEXANECARBOXAMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FASUDIL; H 1077; H 1152P; RECOMBINANT ENZYME; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; PRIORITY JOURNAL; VIRTUAL REALITY;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; RECOMBINANT PROTEINS; RHO-ASSOCIATED KINASES; USER-COMPUTER INTERFACE;

EID: 73749086881     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2009.12.003     Document Type: Article

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