Discovery of PDE10A inhibitor, PF-2545920

Drug Discovery Today

Volumn 15, Issue 1-2, 2010, Pages 79-

  Walker, Michael A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [1 METHYL 4 (4 PYRIDINYL) 3 PYRAZOLYL]PHENOXYMETHYL]QUINOLINE;

DRUG BINDING; DRUG PENETRATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; NONHUMAN; SHORT SURVEY; X RAY CRYSTALLOGRAPHY;

EID: 73749085987     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2009.12.002     Document Type: Short Survey

References (2)

1. Menniti F.S., et al. Phosphodiesterase 10A inhibitors: a novel approach to the treatment of the symptoms of schizophrenia. Curr. Opin. Investig. Drugs 8 (2007) 54-59
2. Verhoest P.R., et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J. Med. Chem. 52 (2009) 5188