Relationship between regulatory T cells and the combination of pegylated interferon and ribavirin for the treatment of chronic hepatitis type C

Intervirology

Volumn 53, Issue 3, 2010, Pages 154-160

  Akiyama, Motohisa ^a   Ichikawa, Tatuki ^a   Miyaaki, Hisamitsu ^a   Motoyoshi, Yasuhide ^a   Takeshita, Shigeyuki ^a   Ozawa, Eisuke ^a   Miuma, Satoshi ^a   Shibata, Hidetaka ^a   Taura, Naota ^a   Nakao, Kazuhiko ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Chronic hepatitis C; Hepatitis C virus; Interferon; Regulatory T cells; Ribavirin

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; PEGINTERFERON; RIBAVIRIN; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; FEMALE; HEPATITIS C; HUMAN; HUMAN TISSUE; LIVER; LIVER BIOPSY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERSISTENT INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD;

AGED; ANTIGENS, CD; ANTIVIRAL AGENTS; BIOPSY; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; LEUKOCYTES, MONONUCLEAR; LIVER; MALE; MIDDLE AGED; RIBAVIRIN; STAINING AND LABELING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

HEPATITIS C VIRUS;

EID: 73649142104     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000274976     Document Type: Article

References (36)

1. Rakela J, Vargas HE: Hepatitis C: magnitude of the problem. Liver Transpl 2002; 8: 3-6. (Pubitemid 35154036)
2. Strader DB, Wright T, Thomas DL, Seeff LB: Diagnosis, management, and treatment of hepatitis C. Hepatology 2004; 39: 1147-1171. (Pubitemid 38428955)
3. Hoofnagle JH: Hepatitis C: the clinical spectrum of disease. Hepatology 1997; 26: 15-20.
4. Gremion C, Cerny A: Hepatitis C virus and the immune system: a concise review. Rev Med Virol 2005; 15: 235-268. (Pubitemid 40992779)
5. Timm J, Roggendorf M: Sequence diversity of hepatitis C virus: implications for immune control and therapy. World J Gastroenterol 2007; 13: 4808-4817. (Pubitemid 47496745)
6. Lohr HF, Gerken G, Roth M, Weyer S, Schlaak JF, Meyer zum Buschenfelde KH: The cellular immune responses induced in the follow-up of interferon-α-treated patients with chronic hepatitis C may determine the therapy outcome. J Hepatol 1998; 29: 524-532. (Pubitemid 28484940)
7. Cerny A, Chisari FV: Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 1999; 30: 595-601. (Pubitemid 29409400)
8. Rehermann B, Nascimbeni M: Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5: 215-229. (Pubitemid 40364823)
9. Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, Dusheiko G, Allen TM, Chung RT, Walker BD, Klenerman, P: High-resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004; 127: 924-936. (Pubitemid 39208424)
10. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH: Infectious tolerance: human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ Thelper cells. J Exp Med 2002; 196: 255-260. (Pubitemid 34787515)
11. Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI: Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells. Blood 2001; 98: 2736-2744.
12. O'Garra A, Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med 2004; 10: 801-805. (Pubitemid 39070850)
13. Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM: Suppression of HCVspecific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003; 38: 1437-1448. (Pubitemid 37466970)
14. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR: An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004; 40: 1062-1071. (Pubitemid 39425561)
15. Boettler T, Spangenberg HC, Neumann- Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsacker F, Thimme R: T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virusspecific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005; 79: 7860-7867. (Pubitemid 40756821)
16. Rushbrook SM, Ward SM, Unitt E, Vowler SL, Lucas M, Klenerman P, Alexander GJ: Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 2005; 79: 7852-7859. (Pubitemid 40756820)
17. Miyaaki H, Zhou H, Ichikawa T, Nakao K, Shibata H, Takeshita S, Akiyama M, Ozawa E, Miuma S, Eguchi K: Study of liver-targeted regulatory T cells in hepatitis B and C virus in chronically infected patients. Liver Int 2009; 29: 702-707.
18. Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, Janssen HL: Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005; 41: 771-778. (Pubitemid 40462939)
19. Longhi MS, Ma Y, Mitry RR, Bogdanos DP, Heneghan M, Cheeseman P, Mieli-Vergani G, Vergani D: Effect of CD4+CD25+ regulatory T cells on CD8 T-cell function in patients with autoimmune hepatitis. J Autoimmun 2005; 25: 63-71. (Pubitemid 41008667)
20. Lan RY, Cheng C, Lian ZX, Tsuneyama K, Yang GX, Moritoki Y, Chuang YH, Nakamura T, Saito S, Shimoda S, Tanaka A, Bowlus CL, Takano Y, Ansari AA, Coppel RL, Gershwin ME: Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology 2006; 43: 729-737.
21. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK: Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-965. (Pubitemid 32913521)
22. Almasio PL, Cottone C, D'Angelo F: Pegylated interferon therapy in chronic hepatitis C: lights and shadows of an innovative treatment. Dig Liver Dis 2007; 39(suppl 1):88-95. (Pubitemid 47528198)
23. Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, Perelson AS: Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-αtherapy. Science 1998; 282: 103-107. (Pubitemid 28471138)
24. Pilli M, Zerbini A, Penna A, Orlandini A, Lukasiewicz E, Pawlotsky JM, Zeuzem S, Schalm SW, von Wagner M, Germanidis G, Lurie Y, Esteban JI, Haagmans BL, Hezode C, Lagging M, Negro F, Homburger Y, Neumann AU, Ferrari C, Missale G: HCV-specific T-cell response in relation to viral kinetics and treatment outcome (DITTO-HCV Project). Gastroenterology 2007; 133: 1132-1143. (Pubitemid 47494444)
25. Herrmann E, Lee JH, Marinos G, Modi M, Zeuzem S: Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon. Hepatology 2003; 37: 1351-1358. (Pubitemid 36667315)
26. Layden-Almer JE, Cotler SJ, Layden TJ: Viral kinetics in the treatment of chronic hepatitis C. J Viral Hepat 2006; 13: 499-504. (Pubitemid 44100400)
27. Dahari H, Ribeiro RM, Perelson AS: Triphasic decline of hepatitis C virus RNA during antiviral therapy. Hepatology 2007; 46: 16-21. (Pubitemid 47171916)
28. Ebinuma H, Nakamoto N, Li Y, Price DA, Gostick E, Levine BL, Tobias J, Kwok WW, Chang KM: Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J Virol 2008; 82: 5043-5053. (Pubitemid 351657064)
29. Ward SM, Fox BC, Brown PJ, Worthington J, Fox SB, Chapman RW, Fleming KA, Banham AH, Klenerman P: Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection. J Hepatol 2007; 47: 316-324. (Pubitemid 47189607)
30. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G: Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J Exp Med 2001; 193: 1303-1310. (Pubitemid 32524780)
31. Levings MK, Sangregorio R, Roncarolo MG: Human CD25+CD4+ T-regulatory cells suppress naive and memory T-cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295-1302. (Pubitemid 32524779)
32. Taura N, Ichikawa T, Hamasaki K, Nakao K, Nishimura D, Goto T, Fukuta M, Kawashimo H, Fujimoto M, Kusumoto K, Motoyoshi Y, Shibata H, Abiru N, Yamasaki H, Eguchi K: Association between liver fibrosis and insulin sensitivity in chronic hepatitis C patients. Am J Gastroenterol 2006; 101: 2752-2759. (Pubitemid 44902647)
33. Payan C, Pivert A, Morand P, Fafi-Kremer S, Carrat F, Pol S, Cacoub P, Perronne C, Lunel F: Rapid and early virological response to chronic hepatitis C treatment with IFNα2 b or PEG-IFNα2 b plus ribavirin in HIV/HCV coinfected patients. Gut 2007; 56: 1111-1116. (Pubitemid 47123242)
34. Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM, Piccirillo CA, Rehermann B: Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood 2006; 107: 4424-4432.
35. Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, Janssen HL: Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B. Virology 2007; 361: 141-148.
36. Landau DA, Rosenzwajg M, Saadoun D, Trebeden-Negre H, Klatzmann D, Cacoub P: Correlation of clinical and virologic responses to antiviral treatment and regulatory T-cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis. Arthritis Rheum 2008; 58: 2897-2907.