Radiation-Induced Reductions in Regional Lung Perfusion: 0.1-12 Year Data From a Prospective Clinical Study

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 2, 2010, Pages 425-432

  Zhang, Junan ^a   Ma, Jinli ^a,b   Zhou, Sumin ^c   Hubbs, Jessica L ^d   Wong, Terence Z ^a   Folz, Rodney J ^e   Evans, Elizabeth S ^a   Jaszczak, Ronald J ^a   Clough, Robert ^a   Marks, Lawrence B ^d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e University of Louisville School of Medicine   (United States)

Author keywords

Lung; Radiation injury; SPECT

Indexed keywords

CLINICAL STUDY; COMPUTED TOMOGRAPHY; DOSE DISTRIBUTIONS; DOSE RESPONSE; DOSE-DEPENDENT; DOSE-RESPONSE CURVES; DOSE-RESPONSE RELATIONS; LINEAR MODEL; LUNG PERFUSION; RADIATION INJURY; RADIATION THERAPY; RADIATION-INDUCED; SPECT IMAGES; SUBVOLUMES; TIME COURSE; TIME POINTS; TREATMENT PLANNING;

BIOLOGICAL ORGANS; BIOLOGICAL RADIATION EFFECTS; POPULATION STATISTICS; THREE DIMENSIONAL; TOMOGRAPHY; TUMORS;

SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FOLLOW UP; HUMAN; LUNG; LUNG CANCER; LUNG PERFUSION; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE DISTRIBUTION; RADIATION INJURY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SKULL; THORAX TUMOR; THREE DIMENSIONAL IMAGING; TIME; TREATMENT PLANNING;

ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; LINEAR MODELS; LUNG; LUNG NEOPLASMS; LYMPHOMA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RADIATION INJURIES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 73649133296     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.02.005     Document Type: Article

References (43)

1. Choi N.C., Kanarek D.J., and Grillo H.C. Effect of postoperative radiotherapy on changes in pulmonary function in patients with stage II and IIIA lung carcinoma. Int J Radiat Oncol Biol Phys 18 (1990) 95-99
2. Kwa S.L., Lebesque J.V., Theuws J.C., et al. Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients. Int J Radiat Oncol Biol Phys 42 (1998) 1-9
3. Rothwell R.I., Kelly S.A., and Joslin C.A. Radiation pneumonitis in patients treated for breast cancer. Radiother Oncol 4 (1985) 9-14
4. Carmel R.J., and Kaplan H.S. Mantle irradiation in Hodgkin's disease. Cancer 37 (1976) 2813-2815
5. Mah K., and Van Dyk J. Quantitative measurement of changes in human lung density following irradiation. Radiother Oncol 11 (1988) 169-179
6. Shapiro S.J., Shapiro S.D., Mill W.B., et al. Prospective study of long-term pulmonary manifestations of mantle irradiation. Int J Radiat Oncol Biol Phys 19 (1990) 707-714
7. Smith L.M., Mendenhall N.P., Cicale M.J., et al. Results of a prospective study evaluating the effects of mantle irradiation on pulmonary function. Int J Radiat Oncol Biol Phys 16 (1989) 79-84
8. Tarbell N.J., Thompson L., and Mauch P. Thoracic irradiation in Hodgkin's disease: disease control and long-term complications. Int J Radiat Oncol Biol Phys 18 (1990) 275-281
9. Kocak Z., Evans E.S., Zhou S.M., et al. Challenges in defining radiation pneumonitis in patients with lung cancer. Int J Radiat Oncol Biol Phys 62 (2005) 635-638
10. Rodrigues G., Lock M., D'Souza D., et al. Prediction of radiation pneumonitis by dose-volume histogram parameters in lung cancer-a systematic review. Radiother Oncol 71 (2004) 127-138
11. Kaufman J., Gunn W., Hartz A.J., et al. The pathophysiologic and roentgenologic effects of chest irradiation in breast carcinoma. Int J Radiat Oncol Biol Phys 12 (1986) 887-893
12. Martel M.K., Ten Haken R.K., Hazuka M.B., et al. Dose-volume histogram and 3-D treatment planning evaluation of patients with pneumonitis. Int J Radiat Oncol Biol Phys 28 (1994) 575-581
13. Mao J., Zhang J., Zhou S., et al. Relating changes in pulmonary function tests (PFTs) to changes in radiation-induced regional lung perfusion. Med Phys 33 (2006) 2151-2152
14. Fan M., Marks L.B., Lind P., et al. Relating radiation-induced regional lung injury to changes in pulmonary function tests. Int J Radiat Oncol Biol Phys 51 (2001) 311-317
15. Boersma L.J., Damen E.M., de Boer R.W., et al. Recovery of overall and local lung function loss 18 months after irradiation for malignant lymphoma. J Clin Oncol 14 (1996) 1431-1441
16. Marks L.B., Spencer D.P., Bentel G.C., et al. Quantification of radiation-induced regional lung injury with perfusion imaging. Int J Radiat Oncol Biol Phys 38 (1997) 399-409
17. Kong F.M., Frey K.A., Quint L.E., et al. A pilot study of (18F)fluorodeoxyglucose positron emission tomography scans during and after radiation-based therapy in patients with non small-cell lung cancer. J Clin Oncol 25 (2007) 3116-3123
18. Woel R.T., Munley M.T., Hollis D., et al. The time course of radiation therapy-induced reductions in regional perfusion: a prospective study with >5 years of follow-up. Int J Radiat Oncol Biol Phys 52 (2002) 58-67
19. Bentel G.C., Marks L.B., and Krishnamurthy R. Impact of cradle immobilization on setup reproducibility during external beam radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys 38 (1997) 527-531
20. Abratt R.P., Willcox P.A., and Smith J.A. Lung cancer in patients with borderline lung functions-zonal lung perfusion scans at presentation and lung function after high dose irradiation. Radiother Oncol 19 (1990) 317-322
21. Bell J., McGivern D., Bullimore J., et al. Diagnostic imaging of post-irradiation changes in the chest. Clin Radiol 39 (1988) 109-119
22. Boersma L.J., Damen E.M., de Boer R.W., et al. Dose-effect relations for local functional and structural changes of the lung after irradiation for malignant lymphoma. Radiother Oncol 32 (1994) 201-209
23. Boersma L.J., Damen E.M., de Boer R.W., et al. A new method to determine dose-effect relations for local lung-function changes using correlated SPECT and CT data. Radiother Oncol 29 (1993) 110-116
24. Groth S., Johansen H., Sorensen P.G., et al. The effect of thoracic irradiation for cancer of the breast on ventilation, perfusion and pulmonary permeability. A one-year follow-up. Acta Oncol 28 (1989) 671-678
25. Marks L.B., Spencer D.P., Bentel G.C., et al. The utility of SPECT lung perfusion scans in minimizing and assessing the physiologic consequences of thoracic irradiation. Int J Radiat Oncol Biol Phys 26 (1993) 659-668
26. Prato F.S., Kurdyak R., Saibil E.A., et al. Physiological and radiographic assessment during the development of pulmonary radiation fibrosis. Radiology 122 (1977) 389-397
27. Maguire P.D., Marks L.B., Sibley G.S., et al. 73.6 Gy and beyond: Hyperfractionated, accelerated radiotherapy for non-small-cell lung cancer. J Clin Oncol 19 (2001) 705-711
28. Koontz B., Zhou S., Evans E., et al. Estimation of the (alpha)/(beta) ratio for lung injury based on direct measurements of radiotherapy (RT)-induced reduction in regional perfusion in human patients. Int J Radiat Oncol Biol Phys 63 Suppl 1 (2005) S457
29. West J.B., and Dollery C.T. Distribution of blood flow and ventilation-perfusion ratio in the lung, measured with radioactive carbon dioxide. J Appl Physiol 15 (1960) 405-410
30. Bryan A.C., Bentivoglio L.G., Beerel F., et al. Factors affecting regional distribution of ventilation and perfusion in the lung. J Appl Physiol 19 (1964) 395-402
31. Petersson J., Rohdin M., Sanchez-Crespo A., et al. Posture primarily affects lung tissue distribution with minor effect on blood flow and ventilation. Respir Physiol Neurobiol 156 (2007) 293-303
32. Seppenwoolde Y., De Jaeger K., Boersma L.J., et al. Regional differences in lung radiosensitivity after radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 60 (2004) 748-758
33. Choi N.C., and Kanarek D.J. Toxicity of thoracic radiotherapy on pulmonary function in lung cancer. Lung Cancer 10 Suppl 1 (1994) S219-S230
34. Marks L.B., Hollis D., Munley M., et al. The role of lung perfusion imaging in predicting the direction of radiation-induced changes in pulmonary function tests. Cancer 88 (2000) 2135-2141
35. Deasy J.O., and El Naqa I. Image-based modeling of normal tissue complication probability for radiation therapy. Cancer Treat Res 139 (2008) 215-256
36. Yorke E.D., Jackson A., Rosenzweig K.E., et al. Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys 54 (2002) 329-339
37. Yorke E.D., Jackson A., Rosenzweig K.E., et al. Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study. Int J Radiat Oncol Biol Phys 63 (2005) 672-682
38. Seppenwoolde Y., Muller S.H., Theuws J.C., et al. Radiation dose-effect relations and local recovery in perfusion for patients with non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 47 (2000) 681-690
39. Theuws J.C., Seppenwoolde Y., Kwa S.L., et al. Changes in local pulmonary injury up to 48 months after irradiation for lymphoma and breast cancer. Int J Radiat Oncol Biol Phys 47 (2000) 1201-1208
40. Garipagaoglu M., Munley M.T., Hollis D., et al. The effect of patient-specific factors on radiation-induced regional lung injury. Int J Radiat Oncol Biol Phys 45 (1999) 331-338
41. Fan M., Marks L.B., Hollis D., et al. Can we predict radiation-induced changes in pulmonary function based on the sum of predicted regional dysfunction?. J Clin Oncol 19 (2001) 543-550
42. Theuws J.C., Kwa S.L., Wagenaar A.C., et al. Prediction of overall pulmonary function loss in relation to the 3-D dose distribution for patients with breast cancer and malignant lymphoma. Radiother Oncol 49 (1998) 233-243
43. Borst G.R., De Jaeger K., Belderbos J.S., et al. Pulmonary function changes after radiotherapy in non-small-cell lung cancer patients with long-term disease-free survival. Int J Radiat Oncol Biol Phys 62 (2005) 639-644