An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity

FEBS Journal

Volumn 277, Issue 1, 2010, Pages 119-127

  Ngai, Stephanie ^a   Batty, Sarah ^a   Liao, Kuo Chieh ^a   Mogridge, Jeremy ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Anthrax; Lethal toxin; MAPKK; Nlrp1b

Indexed keywords

ANTHRAX TOXIN; GLUTAMIC ACID; GLYCINE; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DAMAGE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; ENZYME SUBSTRATE; GENE EXPRESSION SYSTEM; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; LETHAL GENE; MELANOMA CELL; MUTANT; NONHUMAN; PRIORITY JOURNAL; PYROPTOSIS;

ANIMALS; ANTIGENS, BACTERIAL; APOPTOSIS; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CELL LINE; CELL LINE, TUMOR; HOST-PATHOGEN INTERACTIONS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PROTEIN STRUCTURE, TERTIARY; VIRULENCE;

BACILLUS ANTHRACIS; MAMMALIA;

EID: 73649113972     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07458.x     Document Type: Article

References (26)

1. Abrami L, Reig N van der Goot FG (2005) Anthrax toxin: the long and winding road that leads to the kill. Trends Microbiol 13, 72 78.
2. Young JA Collier RJ (2007) Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem 76, 243 265.
3. Warfel JM, Steele AD D'Agnillo F (2005) Anthrax lethal toxin induces endothelial barrier dysfunction. Am J Pathol 166, 1871 1881.
4. Gozes Y, Moayeri M, Wiggins JF Leppla SH (2006) Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice. Infect Immun 74, 1266 1272.
5. Moayeri M, Haines D, Young HA Leppla SH (2003) Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice. J Clin Invest 112, 670 682.
6. Cui X, Moayeri M, Li Y, Li X, Haley M, Fitz Y, Correa-Araujo R, Banks SM, Leppla SH Eichacker PQ (2004) Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol Regul Integr Comp Physiol 286, R699 R709.
7. Baldari CT, Tonello F, Paccani SR Montecucco C (2006) Anthrax toxins: a paradigm of bacterial immune suppression. Trends Immunol 27, 434 440.
8. Banks DJ, Ward SC Bradley KA (2006) New insights into the functions of anthrax toxin. Expert Rev Mol Med 8, 1 18.
9. Tournier JN, Rossi Paccani S, Quesnel-Hellmann A Baldari CT (2009) Anthrax toxins: a weapon to systematically dismantle the host immune defenses. Mol Aspects Med, doi :.
10. Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD et al. (1998) Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280, 734 737.
11. Vitale G, Bernardi L, Napolitani G, Mock M Montecucco C (2000) Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem J 352 Pt 3, 739 745.
12. Abi-Habib RJ, Urieto JO, Liu S, Leppla SH, Duesbery NS Frankel AE (2005) BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin. Mol Cancer Ther 4, 1303 1310.
13. Maldonado-Arocho FJ, Fulcher JA, Lee B Bradley KA (2006) Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells. Mol Microbiol 61, 324 337.
14. Boyden ED Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38, 240 244.
15. Fink SL, Bergsbaken T Cookson BT (2008) Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci USA 105, 4312 4317.
16. Wickliffe KE, Leppla SH Moayeri M (2008) Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome. Cell Microbiol 10, 332 343.
17. Nour AM, Yeung YG, Santambrogio L, Boyden ED, Stanley ER Brojatsch J (2009) Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect Immun 77, 1262 1271.
18. Park JM, Greten FR, Li ZW Karin M (2002) Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297, 2048 2051.
19. Kim SO, Jing Q, Hoebe K, Beutler B, Duesbery NS Han J (2003) Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. J Biol Chem 278, 7413 7421.
20. Koo HM, VanBrocklin M, McWilliams MJ, Leppla SH, Duesbery NS Woude GF (2002) Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. Proc Natl Acad Sci USA 99, 3052 3057.
21. Frankel AE, Koo HM, Leppla SH, Duesbery NS Vande Woude GF (2003) Novel protein targeted therapy of metastatic melanoma. Curr Pharm Des 9, 2060 2066.
22. Liang X, Young JJ, Boone SA, Waugh DS Duesbery NS (2004) Involvement of domain II in toxicity of anthrax lethal factor. J Biol Chem 279, 52473 52478.
23. Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC Cantley LC (2004) The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol 11, 60 66.
24. Liao KC Mogridge J (2009) Expression of Nlrp1b inflammasome components in human fibroblasts confers susceptibility to anthrax lethal toxin. Infect Immun 77, 4455 4462.
25. Miller CJ, Elliott JL Collier RJ (1999) Anthrax protective antigen: prepore-to-pore conversion. Biochemistry 38, 10432 10441.
26. Humphrey W, Dalke A Schulten K (1996) VMD: visual molecular dynamics. J Mol Graph 14, 33 38.