Proton Beam Therapy for Large Hepatocellular Carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 2, 2010, Pages 460-466

  Sugahara, Shinji ^a,b   Oshiro, Yoshiko ^a,b   Nakayama, Hidetsugu ^a,b   Fukuda, Kuniaki ^a   Mizumoto, Masashi ^a,b   Abei, Masato ^a   Shoda, Junichi ^a   Matsuzaki, Yasushi ^c   Thono, Eriko ^a   Tokita, Mari ^d   Tsuboi, Koji ^a,b   Tokuuye, Koichi ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TSUKUBA HOSPITAL   (Japan)

^c Ibaraki pref   (Japan)

^d BROWN UNIVERSITY   (United States)

Author keywords

Large hepatocellular carcinoma; Proton beam therapy; Radiotherapy

Indexed keywords

BRAGG PEAKS; CLINICAL TARGET VOLUMES; CONFORMALITY; DOSE EXPOSURE; HEPATIC TUMORS; HEPATOCELLULAR CARCINOMA; HIGH DOSE; MULTIFOCAL; NORMAL TISSUE; OLD AGE; PORTAL VEINS; PROGRESSION FREE SURVIVAL; PROTON BEAM THERAPY; TOTAL DOSE; TUMOR CONTROL; TUMOR PROGRESSIONS; TUMOR SIZE; TUMOR VOLUMES; UP PERIOD;

BIOACCUMULATION; PROTON BEAMS; PROTONS; RADIOTHERAPY;

TUMORS;

ADULT; ADVANCED CANCER; AGE DISTRIBUTION; AGED; ARTICLE; CANCER CONTROL; CANCER GROWTH; CANCER RECURRENCE; CANCER SIZE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; FEMALE; FOLLOW UP; HUMAN; LEUKOCYTE COUNT; LIVER CELL CARCINOMA; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PATIENT SAFETY; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTON THERAPY; RADIATION DOSE FRACTIONATION; RADIATION INJURY; SKIN DISEASE; THROMBOCYTE COUNT; TREATMENT OUTCOME; TUMOR VOLUME;

AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PORTAL VEIN; PROTONS; SURVIVAL RATE; THROMBOSIS;

EID: 73649107919     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.02.030     Document Type: Article

References (49)

1. Parkin D.M., Bray F., Ferlay J., et al. Global cancer statistics. CA Cancer J Clin 2005 55 (2002) 74-108
2. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. The Liver Cancer Study Group of Japan. Cancer 74 (1994) 2772-2780
3. Vilana R., Bruix J., Bru C., et al. Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Hepatology 16 (1992) 353-357
4. Harada T., Matsuo K., Inoue T., et al. Is preoperative hepatic arterial chemoembolization safe and effective for hepatocellular carcinoma?. Ann Surg 224 (1996) 4-9
5. Livraghi T., Bolondi L., Lazzaroni S., et al. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients. Cancer 69 (1992) 925-929
6. Tanaka K., Nakamura S., Numata K., et al. The long term efficacy of combined transcatheter arterial embolization and percutaneous ethanol injection in the treatment of patients with large hepatocellular carcinoma and cirrhosis. Cancer 82 (1998) 78-85
7. Chia-Hsien Cheng J., Chuang V.P., Cheng S.H., et al. Unresectable hepatocellular carcinoma treated with radiotherapy and/or chemoembolization. Int J Cancer 96 (2001) 243-252
8. Livraghi T., Goldberg S.N., Lazzaroni S., et al. Hepatocellular carcinoma: Radio-frequency ablation of medium and large lesions. Radiology 214 (2000) 761-768
9. Bruix J., and Sherman M. Management of hepatocellular carcinoma. Hepatology 42 (2005) 1208-1236
10. Yokoyama I., Todo S., Iwatsuki S., et al. Liver transplantation in the treatment of primary liver cancer. Hepatogastroenterology 37 (1990) 188-193
11. Haug C.E., Jenkins R.L., Rohrer R.J., et al. Liver transplantation for primary hepatic cancer. Transplantation 53 (1992) 376-382
12. Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35 (2001) 421-430
13. Capussotti L., Ferrero A., Vigano L., et al. Liver resection for HCC with cirrhosis: Surgical perspectives out of EASL/AASLD guidelines. Eur J Surg Oncol 35 (2009) 11-15
14. Noguchi T., Kawarada Y., Kitagawa M., et al. Clinicopathologic factors influencing the long-term prognosis following hepatic resection for large hepatocellular carcinoma more than 10 cm in diameter. Semin Oncol 24 2 Suppl. 6 (1997) S6-7-S6-13
15. Lee N.H., Chau G.Y., Lui W.Y., et al. Surgical treatment and outcome in patients with a hepatocellular carcinoma greater than 10 cm in diameter. Br J Surg 85 (1998) 1654-1657
16. Poon R.T., Fan S.T., and Wong J. Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter. J Am Coll Surg 194 (2002) 592-602
17. Zhou X.D., Tang Z.Y., Ma Z.C., et al. Surgery for large primary liver cancer more than 10 cm in diameter. J Cancer Res Clin Oncol 129 (2003) 543-548
18. Liau K.H., Ruo L., Shia J., et al. Outcome of partial hepatectomy for large (> 10 cm) hepatocellular carcinoma. Cancer 104 (2005) 1948-1955
19. Pandey D., Lee K.H., Wai C.T., et al. Long term outcome and prognostic factors for large hepatocellular carcinoma (10 cm or more) after surgical resection. Ann Surg Oncol 14 (2007) 2817-2823
20. Mok K.T., Wang B.W., Lo G.H., et al. Multimodality management of hepatocellular carcinoma larger than 10 cm. J Am Coll Surg 197 (2003) 730-738
21. Hawkins M.A., and Dawson L.A. Radiation therapy for hepatocellular carcinoma: From palliation to cure. Cancer 106 (2006) 1653-1663
22. Hashimoto T., Tokuuye K., Fukumitsu N., et al. Repeated proton beam therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 65 (2006) 196-202
23. Hata M., Tokuuye K., Sugahara S., et al. Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis. Strahlenther Onkol 182 (2006) 713-720
24. Hata M., Tokuuye K., Sugahara S., et al. Proton beam therapy for hepatocellular carcinoma with portal vein tumor thrombus. Cancer 104 (2005) 794-801
25. Hata M., Tokuuye K., Sugahara S., et al. Proton irradiation in a single fraction for hepatocellular carcinoma patients with uncontrollable ascites. Technical considerations and results. Strahlenther Onkol 183 (2007) 411-416
26. Hata M., Tokuuye K., Sugahara S., et al. Proton beam therapy for aged patients with hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 69 (2007) 805-812
27. Chiba T., Tokuuye K., Matsuzaki Y., et al. Proton beam therapy for hepatocellular carcinoma: A retrospective review of 162 patients. Clin Cancer Res 11 (2005) 3799-3805
28. Oken M.M., Creech R.H., Tormey D.C., et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5 (1982) 649-655
29. Tsunashima Y., Sakae T., Shioyama Y., et al. Correlation between the respiratory waveform measured using a respiratory sensor and 3D tumor motion in gated radiotherapy. Int J Radiat Oncol Biol Phys 60 (2004) 951-958
30. Fowler J.F. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 62 (1989) 679-694
31. Cox J.D., Stetz J., and Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995) 1341-1346
32. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 31 (1958) 457-481
33. Altman D.G. Practical statistics for medical research. 2nd ed. (2004), Chapman and Hall, London
34. Lawrence T.S., Robertson J.M., Anscher M.S., et al. Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 31 (1995) 1237-1248
35. Sakurai M., Okamura J., and Kuroda C. Transcatheter chemo-embolization effective for treating hepatocellular carcinoma. A histopathologic study. Cancer 54 (1984) 387-392
36. Nakamura H., Tanaka T., Hori S., et al. Transcatheter embolization of hepatocellular carcinoma: Assessment of efficacy in cases of resection following embolization. Radiology 147 (1983) 401-405
37. Takayasu K., Moriyama N., Muramatsu Y., et al. Hepatic arterial embolization for hepatocellular carcinoma. Comparison of CT scans and resected specimens. Radiology 150 (1984) 661-665
38. Sitruk V., Seror O., Grando-Lemaire V., et al. [Percutaneous ablation of hepatocellular carcinoma]. Gastroenterol Clin Biol 27 (2003) 381-390
39. Shiina S., Teratani T., Obi S., et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology 129 (2005) 122-130
40. Lin S.M., Lin C.J., Lin C.C., et al. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4 cm. Gastroenterology 127 (2004) 1714-1723
41. Lencioni R.A., Allgaier H.P., Cioni D., et al. Small hepatocellular carcinoma in cirrhosis: Randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology 228 (2003) 235-240
42. Emami B., Lyman J., Brown A., et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21 (1991) 109-122
43. Lawrence T.S., Ten Haken R.K., Kessler M.L., et al. The use of 3-D dose volume analysis to predict radiation hepatitis. Int J Radiat Oncol Biol Phys 23 (1992) 781-788
44. Liang S.X., Zhu X.D., Lu H.J., et al. Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma. Cancer 103 (2005) 2181-2188
45. Dawson L.A., McGinn C.J., Normolle D., et al. Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies. J Clin Oncol 18 (2000) 2210-2218
46. Ben-Josef E., Normolle D., Ensminger W.D., et al. Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies. J Clin Oncol 23 (2005) 8739-8747
47. Teratani T., Shiina S., Yoshida H., et al. Prediction of recurrence of hepatocellular carcinoma after curative ablation using three tumor markers. Hepatology 44 (2006) 1518-1527
48. Rougier P., Mitry E., Barbare J.C., et al. Hepatocellular carcinoma (HCC): An update. Semin Oncol 34 (2007) S12-S20
49. Zhu A.X. Systemic therapy of advanced hepatocellular carcinoma: How hopeful should we be?. Oncologist 11 (2006) 790-800