HPV viral activity by mRNA-HPV molecular analysis to screen the transforming infections in precancer cervical lesions

Current Pharmaceutical Biotechnology

Volumn 10, Issue 8, 2009, Pages 767-771

  Tinelli, Andrea ^a   Leo, Giuseppe ^a   Pisanò, Maurizio ^a   Storelli, Fabio ^a   Leo, Sara ^a   Vergara, Daniele ^b   Malvasi, Antonio ^c  

^a VITO FAZZI HOSPITAL   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

^c Santa Maria Hospital   (Italy)

Author keywords

Cervical cancer; Cervical intraepithelial neoplasia; CIN; DNA; High risk HPV; HPV; Human papillomavirus; mRNA; NASBA; REAL time PCR squamous intraepithelial lesion; SIL

Indexed keywords

MESSENGER RNA; PROTEIN E6; PROTEIN E7;

ADULT; ARTICLE; CAPILLARY ELECTROPHORESIS; CONDYLOMA ACUMINATUM; CONTROLLED STUDY; CYTOLOGY; DNA VIRUS; FEMALE; GENE AMPLIFICATION; GENETIC TRANSCRIPTION; GENOTYPE; HIGH RISK POPULATION; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MOLECULAR BIOLOGY; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE PROBE; OPEN READING FRAME; PAPANICOLAOU TEST; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX MUCUS; WART VIRUS;

ADULT; CERVICAL INTRAEPITHELIAL NEOPLASIA; COHORT STUDIES; DNA PROBES, HPV; FEMALE; HUMANS; NUCLEIC ACID HYBRIDIZATION; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PRECANCEROUS CONDITIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, VIRAL; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

HUMAN PAPILLOMAVIRUS;

EID: 73649105111     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109789978739     Document Type: Article

References (16)

1. zur Hausen, H. (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer, 2, 342-350.
2. Burd, E.M. (2003) Human papillomavirus and cervical cancer. Clin. Microbiol. Rev., 16(1),1-17.
3. Doorbar, J. (2006) Molecular biology of human papillomavirus infection and cervical cancer. Clin. Sci., (Lond), 110, 525-541.
4. Doorbar, J. (2005) The papillomavirus life cycle. J. Clin. Virol., 32 (Suppl 1), S7-15.
5. Hebner, C.M. and Laimins, L.A. (2006) Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity. Rev. Med. Virol., 16, 83-97.
6. Cuschieri, K. and Wentzensen, N. (2008) Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol. Biomarkers Prev., 17(10), 2536-2545.
7. Tinelli, A.; Vergara, D.; Leo, G.; Malvasi, A.; Casciaro, S.; Leo, E.; Montinari, M.R.; Maffia, M.; Marsigliante, S. and Lorusso, V. (2007) Human papillomavirus genital infection in modern gynaecology: genetic and genomic aspects. Eur. Clin. Obstet. Gynaecol., 3, 1-6.
8. de Sanjosé, S.; Diaz, M.; Castellsagué, X.; Clifford, G.; Bruni, L.; Muñoz, N. and Bosch, F.X. (2007) Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect. Dis., 7, 453-459.
9. Munoz, N.; Bosch, F.X.; de Sanjose, S.; Herrero, R.; Castellsagué, X.; Shah, K.V.; Snijders, P.J. and Meijer, C.J. International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med., 348, 518-527.
10. Münger, K. and Howley, P. (2002) Human papillomavirus immortalization and transformation functions. Virus Res., 89, 213-228.
11. Schwartz, S. (2008) HPV-16 RNA processing. Front Biosci., 13, 5880-5891.
12. Kulasingam, S.L.; Hughes, J.P.; Kiviat, N.B.; Mao, C.; Weiss, N.S.; Kuypers, J.M. and Koutsky, L.A. (2002) Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral. JAMA, 288(14), 1749-1757.
13. Cuzick, J.; Szarewski, A.; Cubie, H.; Hulman, G.; Kitchener, H.; Luesley, D.; McGoogan, E.; Menon, U.; Terry, G.; Edwards, R.; Brooks, C.; Desai, M.; Gie, C.; Ho, L.; Jacobs, I.; Pickles, C.and Sasieni, P. (2003) Management of women who test positive for high-risk types of human papillomavirus: the HART study. Lancet, 362(9399), 1871-1876.
14. Lie, A.K. and Kristensen, G. (2008) Human papillomavirus E6/E7 mRNA testing as a predictive marker for cervical carcinoma. Expert Rev. Mol. Diagn., 8(4), 405-415.
15. Khan, A.M. and Singer, A. (2008) Biomarkers in cervical precancer management: the new frontiers. Future Oncol., 4(4), 515-524.
16. Molden, T.; Kraus, I.; Karlsen, F.; Skomedal, H.; Nygård, J.F.; Hagmar, B. (2005) Comparison of human papillomavirus messenger RNA and DNA detection: a cross-sectional study of 4,136 women >30 years of age with a 2-year follow-up of high-grade squamous intraepithelial lesion. Cancer Epidemiol. Biomarkers Prev., 14, 367-372.