Methotrexate-associated lymphoproliferative disorders mimicking angioimmunoblastic T-cell lymphoma

Pathology Research and Practice

Volumn 206, Issue 1, 2010, Pages 9-13

  Hatanaka, Kazuhito ^a   Nakamura, Naoya ^b   Kojima, Minoru ^b   Ando, Kiyoshi ^b   Irie, Seiji ^a   Bunno, Maki ^c   Nakamine, Hirokazu ^d   Uekusa, Toshimasa ^a  

^a KANTO ROSAI HOSPITAL   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Saiseikai Wakayama Hospital   (Japan)

^d KANSAI UNIVERSITY OF HEALTH SCIENCES   (Japan)

Author keywords

Angioimmunoblastic T cell lymphoma; Epstein barr virus; Lymphoproliferative disorders; Methotrexate

Indexed keywords

CD8 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; METHOTREXATE; PREDNISOLONE; VINCRISTINE;

AGED; ARTICLE; B LYMPHOCYTE; CASE REPORT; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG SAFETY; DRUG WITHDRAWAL; EPSTEIN BARR VIRUS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLASTIC LYMPHOMA; LYMPHADENOPATHY; LYMPHOCYTIC INFILTRATION; LYMPHOPROLIFERATIVE DISEASE; MALE; MULTIPLE CYCLE TREATMENT; RHEUMATOID ARTHRITIS; T CELL LYMPHOMA; T LYMPHOCYTE; VIRUS INFECTION;

AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DIAGNOSIS, DIFFERENTIAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOBLASTIC LYMPHADENOPATHY; LYMPHOMA, T-CELL; LYMPHOPROLIFERATIVE DISORDERS; MALE; METHOTREXATE;

EID: 73649101356     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.03.005     Document Type: Article

References (12)

1. Tishler M., Capsi D., and Yaron M. Long-term prospective study of the use of methotrextate in the treatment of rheumatoid arthritis: update after a mean of 90 months. Arthritis Rheum. 35 (1992) 138-145
2. Salloum E., Cooper D.L., Howe G., Lacy J., Tallini G., Crouch J., Schultz M., and Murren J. Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J. Clin. Oncol. 14 (1996) 1943-1949
3. Gaulard P., Swerdlow S.H., Harris N.L., Jaffe E.S., and Sundström C. Other iatrogenic immunodeficiency-associated lymphoproliferative disorders. In: Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., Thiele J., and Vardiman J.W. (Eds). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (2008), IARC Press, Lyon 350-351
4. Thomas E., Brewster D.H., Black R.J., and Macfarlane G.J. Risk of malignancy among patients with rheumatic conditions. Int. J. Cancer 88 (2000) 497-502
5. Georgescu L., and Paget S.A. Lymphoma in patients with rheumatoid arthritis: what is the evidence of a link with methotrexate?. Drug Saf. 20 (1999) 475-487
6. Feng W.H., Cohen J.I., Fischer S., Li L., Sneller M., Goldbach-Mansky R., Raab-Traub N., Delecluse H.J., and Kenney S.C. Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas. J. Natl. Cancer Inst. 96 (2004) 1691-1702
7. Wolfe F., and Michaud K. The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation. Arthritis Rheum. 56 (2007) 1433-1439
8. Abbondazo S.L., Irey N.S., and Frizzera G. Dilantin-associated lymphadenopathy. Spectrum of histopathologic patterns. Am. J. Surg. Pathol. 19 (1995) 675-686
9. Lee S.S., Rüdiger T., Odenwald T., Roth S., Starostik P., and Müller-Hermelink H.K. Angioimmunoblastic T cell lymphoma is derived from mature T-helper cells with varying expression and loss of detectable CD4. Int. J. Cancer 103 (2003) 12-20
10. Attygalle A., Al-Jehani R., Diss T.C., Munson P., Liu H., Du M.Q., Isaacson P.G., and Dogan A. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 99 (2002) 627-633
11. Kojima M., Itoh H., Hirabayashi K., Igarashi S., Tamaki Y., Murayama K., Ogura H., Saitoh R., Kashiwabara K., Takimoto J., Masawa N., and Nakamura S. Methtrexate-associated lymphoproliferative disorders. A clinicopathological study of 13 Japanese cases. Pathol. Res. Pract. 202 (2006) 679-685
12. Hoshida Y., Xu J.X., Fujita S., Nakamichi I., Ikeda J., Tomita Y., Nakatsuka S., Tamaru J., Iizuka A., Takeuchi T., and Aozasa K. Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication. J. Rheumatol. 34 (2007) 322-331